Extracellular superoxide dismutase and cardiovascular disease.

Abstract

Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O(2)(*-)), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O(2)(*-) are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases.

• Authors: Tohru Fukai, Rodney J Folz, Ulf Landmesser, David G Harrison
• Journal: Cardiovascular research (Cardiovasc Res) Vol. 55 Issue 2 Pg. 239-49 (Aug 01 2002) ISSN: 0008-6363 [Print] England
• PMID: 12123763 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)

Chemical References

• Nitric Oxide
• Superoxide Dismutase

Topics

• Animals
• Arteriosclerosis (physiopathology)
• Cardiovascular Diseases (physiopathology)
• Humans
• Hypertension (physiopathology)
• Nitric Oxide (physiology)
• Reperfusion Injury (physiopathology)
• Superoxide Dismutase (physiology)