Abstract | OBJECTIVE: DESIGN: Prospective data analysis. SETTING: Volunteer women in an academic research environment. PATIENT(S): Six lean and 31 obese subjects, aged 19-33 years. INTERVENTION(S): Patients were treated for 5-6 weeks with NAC at a dose of 1.8 g/day orally. A dose of 3 g/day was arbitrarily chosen for massively obese subjects. Six of 31 obese patients with PCOS were treated with placebo and served as controls. MAIN OUTCOME MEASURE(S): Before and after the treatment period, the hormonal and lipid blood profile and insulin sensitivity, assessed by an hyperinsulinemic euglycemic clamp, were evaluated and an oral glucose tolerance test (OGTT) was performed. RESULT(S): Fasting glucose, fasting insulin, and glucose area under curve (AUC) were unchanged after treatment. Insulin AUC after OGTT was significantly reduced, and the peripheral insulin sensitivity increased after NAC administration, whereas the hepatic insulin extraction was unaffected. The NAC treatment induced a significant fall in T levels and in free androgen index values (P<.05). In analyzing patients according to their insulinemic response to OGTT, normoinsulinemic subjects and placebo-treated patients did not show any modification of the above parameters, whereas a significant improvement was observed in hyperinsulinemic subjects. CONCLUSION(S):
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Authors | Anna Maria Fulghesu, Mario Ciampelli, Giuseppe Muzj, Chiara Belosi, Luigi Selvaggi, Gian Franco Ayala, Antonio Lanzone |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 77
Issue 6
Pg. 1128-35
(Jun 2002)
ISSN: 0015-0282 [Print] United States |
PMID | 12057717
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Androgens
- Insulin
- Testosterone
- Acetylcysteine
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Topics |
- Acetylcysteine
(administration & dosage, therapeutic use)
- Adult
- Androgens
(blood)
- Drug Administration Schedule
- Female
- Glucose Tolerance Test
- Humans
- Hyperinsulinism
(blood)
- Insulin
(blood, metabolism)
- Insulin Resistance
(physiology)
- Liver
(metabolism)
- Polycystic Ovary Syndrome
(drug therapy, physiopathology)
- Prospective Studies
- Testosterone
(blood)
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