Abstract | BACKGROUND AND PURPOSE: METHODS: RESULTS:
Cerebral infarct was reduced by >50% in TIA- versus sham-preconditioned animals. 2C11 mRNA and protein were increased in ipsilateral hemisphere by 3 days after TIA but not sham surgery. Induction of 2C11 by TIA was also evident in ipsilateral hemisphere at 24 hours after 2-hour middle cerebral artery occlusion and 24 hours of reperfusion. End-ischemic regional CBF was not different between TIA- and sham-pretreated groups. CONCLUSIONS: We conclude that experimental TIA induces ischemic tolerance by a mechanism temporally linked to upregulation of P450 2C11. Enzyme induction does not attenuate ischemic severity by amplifying end-ischemic CBF.
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Authors | Nabil J Alkayed, Toru Goyagi, Hung-Dong Joh, Judith Klaus, David R Harder, Richard J Traystman, Patricia D Hurn |
Journal | Stroke
(Stroke)
Vol. 33
Issue 6
Pg. 1677-84
(Jun 2002)
ISSN: 1524-4628 [Electronic] United States |
PMID | 12053011
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- RNA, Messenger
- Cytochrome P-450 Enzyme System
- Steroid Hydroxylases
- Aryl Hydrocarbon Hydroxylases
- Steroid 16-alpha-Hydroxylase
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Topics |
- Animals
- Aryl Hydrocarbon Hydroxylases
- Autoradiography
- Blood Flow Velocity
- Blotting, Western
- Brain
(blood supply, metabolism, pathology)
- Cerebrovascular Circulation
- Cytochrome P-450 Enzyme System
(genetics, metabolism)
- Disease Models, Animal
- Enzyme Induction
- Female
- Infarction, Middle Cerebral Artery
(metabolism, pathology)
- Ischemic Attack, Transient
(metabolism)
- Ischemic Preconditioning
- Liver
(enzymology)
- Male
- RNA, Messenger
(metabolism)
- Rats
- Rats, Wistar
- Reperfusion
- Steroid 16-alpha-Hydroxylase
- Steroid Hydroxylases
(genetics, metabolism)
- Up-Regulation
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