Abstract | AIM:
Chondroblastomas and chondromyxoidfiibromas are rare benign skeletal neoplasms with reported overlapping histology. Aim of this study was to analyse the biochemical composition of the matrix of these tumour entities in order to further characterise the cellular phenotypes of these neoplasms using typical cell biological marker genes. METHODS: The matrix compositions of chondroblastomas and chondromyxoidfibromas were analyzed by HE-histology, histochemistry, and immunolocalization techniques. Cellular gene expression patterns were detected by mRNA in situ hybridization. RESULTS:
Chondroblastomas are rich in collagen type I and show foci of an osteoid-like matrix, whereas collagen type II as a typical marker of chondrocytic differentiation was not detected in any of the specimens. Chondromyxoidfiibromas had foci of chondroid appearance with chondroblastic cellular differentiation characterised by collagen type II expression. CONCLUSION:
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Authors | C M Schörle, C Inwards, K K Unni, T Kirchner, T Aigner |
Journal | Zeitschrift fur Orthopadie und ihre Grenzgebiete
(Z Orthop Ihre Grenzgeb)
2002 Mar-Apr
Vol. 140
Issue 2
Pg. 208-13
ISSN: 0044-3220 [Print] Germany |
Vernacular Title | Charakterisierung und Differenzierung von Chondroblastomen und Chondromyxoidfibromen - Präsenz und Expression der Kollagentypen I und II. |
PMID | 12029596
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Biomarkers, Tumor
- Collagen Type I
- Collagen Type II
|
Topics |
- Biomarkers, Tumor
(analysis)
- Bone Neoplasms
(pathology)
- Bone and Bones
(pathology)
- Chondroblastoma
(pathology)
- Chondroma
(pathology)
- Collagen Type I
(analysis)
- Collagen Type II
(analysis)
- Diagnosis, Differential
- Humans
|