Lactic dehydrogenase virus (LDV) infection inhibits allergic eosinophil reaction in the airway.

Abstract

The effects of interferon (IFN)-gamma induced by virus infection on eosinophil reaction in allergic airway inflammation are not yet clear. We investigated the effects of lactic dehydrogenase virus (LDV) infection, which increases IFN -gamma production with no viral infection or replication in respiratory epithelium, on allergic airway hypersensitivity. LDV infection suppressed antigen-induced eosinophil recruitment into the airway in sensitized mice. IL -5 gene expression in bronchoalveolar lavage (BAL) cells was significantly suppressed in LDV -infected mice compared with uninfected controls. The numbers of total T cells and CD 4+ T cells were significantly reduced in LDV -infected mice compared with controls. The present results suggested that the increase in production of IFN -gamma by viral infection suppresses the eosinophil reaction, and this suppressive effect may be mediated by inhibition of the recruitment of CD 4+ T cell and IL -5 production.

• Authors: M Morimoto, T Ohji, H Iwata, T Hayashi
• Journal: Research in veterinary science (Res Vet Sci) Vol. 72 Issue 2 Pg. 131-6 (Apr 2002) ISSN: 0034-5288 [Print] England
• PMID: 12027593 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2002 Published by Elsevier Science Ltd.

Chemical References

• Allergens
• Interleukin-5
• RNA, Messenger
• Interferon-gamma
• Ovalbumin

Topics

• Allergens (immunology)
• Animals
• Arterivirus Infections (immunology)
• Base Sequence
• Bronchoalveolar Lavage
• CD4-Positive T-Lymphocytes (immunology)
• Eosinophils (immunology)
• Gene Expression Regulation
• Hypersensitivity (immunology)
• Interferon-gamma (immunology)
• Interleukin-5 (biosynthesis, genetics)
• Lactate dehydrogenase-elevating virus (immunology)
• Male
• Mice
• Ovalbumin (immunology)
• RNA, Messenger (genetics, metabolism)
• Respiratory System (immunology)
• Reverse Transcriptase Polymerase Chain Reaction
• Rodent Diseases (immunology, virology)