Abstract | OBJECTIVE: METHODS: Treatment modalities and study design have been described recently. Immunohistochemistry was used to visualize expression of CAR and integrins alphavbeta3 and alphavbeta5 in tumor samples taken before and after application of GT. RESULTS: CONCLUSION: Despite the importance of CAR and integrin expression for successful adenovirus internalization, other cell surface receptors might be involved in this process. It is too early to decide whether expressions of CAR and integrin alphavbeta3/alphavbeta5 on tumor cells are appropriate additional inclusion criteria for the enrollment of patients in GT trials. Further research is necessary to evaluate the effect of GT plus chemotherapy on CAR and integrin expression.
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Authors | A Hasenburg, D-C Fischer, X-W Tong, A Rojas-Martinez, R H Kaufman, I Ramzy, P Kohlberger, M Orlowska-Volk, E Aguilar-Cordova, D G Kieback |
Journal | Journal of the Society for Gynecologic Investigation
(J Soc Gynecol Investig)
2002 May-Jun
Vol. 9
Issue 3
Pg. 174-80
ISSN: 1071-5576 [Print] United States |
PMID | 12009393
(Publication Type: Clinical Trial, Clinical Trial, Phase I, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Integrins
- Receptors, Vitronectin
- integrin alphaVbeta5
- Thymidine Kinase
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Topics |
- Adult
- Aged
- Dose-Response Relationship, Drug
- Enterovirus
(genetics)
- Female
- Genetic Therapy
(adverse effects, methods)
- Genetic Vectors
- Humans
- Integrins
(genetics)
- Middle Aged
- Neoplasm Staging
- Ovarian Neoplasms
(pathology, surgery, therapy)
- Receptors, Vitronectin
(genetics)
- Recurrence
- Second-Look Surgery
- Thymidine Kinase
(genetics)
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