Thymidine Kinase

An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.

Also Known As:

Networked: 2454 relevant articles (144 outcomes, 255 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gambhir, Sanjiv S: 19 articles (09/2012 - 05/2002)
2.	Castro, Maria G: 13 articles (03/2014 - 11/2002)
3.	Lowenstein, Pedro R: 13 articles (03/2014 - 11/2002)
4.	Aguilar-Cordova, E: 12 articles (05/2002 - 02/2000)
5.	Moore, Martha M: 11 articles (01/2013 - 01/2002)
6.	Ylä-Herttuala, Seppo: 10 articles (01/2015 - 11/2002)
7.	Candolfi, Marianela: 10 articles (03/2014 - 08/2005)
8.	Ylä-Herttuala, S: 9 articles (04/2015 - 01/2000)
9.	Puntel, Mariana: 9 articles (03/2014 - 08/2005)
10.	Liu, Chunyan: 9 articles (05/2013 - 08/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2009 - "In a therapeutic approach using the suicide gene herpes simplex virus thymidine kinase (HSV-1-tk) fused to eGFP, both lentiviral vectors mediated a complete remission of solid tumors as seen on MRI resulting in a highly significant survival benefit (p<0.001) compared to control groups. " 10/01/2004 - "The present study examines the efficacy of these insulators elements, when two independent expression cassettes (one in which a strong, ubiquitous promoter drives the expression of the green fluorescent protein and another in which the "cancer-selective" ERBB2 promoter drives the expression of the herpes simplex virus thymidine kinase [HSVtk] gene) are incorporated into the same recombinant adenovirus. " 04/01/2012 - "When we administrated adenoviruses harboring the herpes simplex virus thymidine kinase gene (Ad5.CMV.HSV.tk) into STAT3-silenced CT26 cell tumors, extensive apoptosis was observed and there was a significant reduction in the size of CT26 cell tumors. " 11/01/2004 - "Gene therapy with Herpes Simplex Virus thymidine kinase gene (HSV-tk) is effective in various tumor models in vitro and in vivo. " 09/01/2003 - "However, coexpression of the Herpes Simplex Virus thymidine kinase gene (HSVtk) and CCL20, cured large established tumors where HSVtk expression alone was not sufficient. "
2.	Glioma (Gliomas) 12/01/2012 - "Recent clinical trials for malignant glioma have drawn attention to the potential therapeutic efficacy of herpes simplex virus-thymidine kinase (HSV-tk) suicide gene therapy. " 10/01/1992 - "The authors recently utilized a thymidine kinase-negative herpes simplex-1 mutant virus, dlsptk, with reduced neurovirulence, for the effective treatment of malignant human gliomas in cell culture and in nude mouse in vivo models. " 12/20/2011 - "Furthermore, I will focus on the use of the Herpes simplex virus-thymidine kinase for gene therapy of malignant gliomas and highlight the efficacy of gene therapy for the treatment of malignant gliomas, but other strategies will also be mentioned. " 03/04/2005 - "Migratory neural stem cells for improved thymidine kinase-based gene therapy of malignant gliomas." 01/01/1998 - "In this experiment, we evaluated the efficacy of AAV vector containing the herpes simplex virus thymidine kinase (HSV-tk) gene on human gliomas transplanted into the brain of nude mice. "
3.	Herpes Simplex 01/01/2008 - "Cancer gene therapy using the herpes simplex thymidine kinase (HSV-TK) suicide gene is a promising treatment, and TK has been used in clinical trials with some success. " 01/01/1997 - "Tumours smaller than 20 mm3 can be cured with defective retrovirus that do not carry the Herpes simplex thymidine kinase (Hsvtk) gene. " 09/01/1995 - "The role of immunosuppression in the efficacy of cancer gene therapy using adenovirus transfer of the herpes simplex thymidine kinase gene." 08/15/2005 - "In spite of preclinical efficacy and recent randomized, controlled studies with adenoviral vectors expressing herpes simplex virus-1 thymidine kinase (HSV1-TK) showing statistically significant increases in survival, most clinical trials using single therapies have failed to provide major therapeutic breakthroughs. " 02/01/2005 - "The feasibility of the strategy has been demonstrated in clinical studies using T cells modified by retroviral transduction to encode the herpes simplex thymidine kinase (HSVTK) gene to treat patients with haematological malignancies. "
4.	Infection 01/01/1987 - "Therapy was similarly effective against infections in guinea pigs induced by a thymidine kinase-negative virus strain, except that lesion virus titers were somewhat increased in animals treated 3 times daily. " 04/01/1999 - "The protective efficacy of the IFN-alpha 1 transgene antagonized viral replication, as evidenced by the reduction of the viral gene transcripts (infected cell polypeptide 27, thymidine kinase, and viral protein 16) and viral load in eyes and trigeminal ganglia during acute infection. " 03/01/2001 - "In this study, we examined the potential of protease pretreatment to improve the efficacy of a gene therapy strategy for prodrug activation that depends on infection with a recombinant adenovirus encoding herpes simplex virus thymidine kinase (Ad-HSV-tk). " 01/01/1998 - "Overall, the study confirmed that thymidine kinase inhibitors can suppress the replication of HSV in vivo, and suggest that such inhibitors may reduce reactivation of the virus from latency if used prophylactically in recurrent HSV infection." 07/01/1987 - "Infection of trigeminal ganglion by herpes simplex virus (HSV) thymidine kinase-negative (TK-) mutants was investigated in mixed infection studies in mice. "
5.	Melanoma (Melanoma, Malignant) 01/01/2014 - "This study investigates the possibility of gene transfer via bone marrow mesenchymal stem cells in anti-cancer gene therapy using a metastatic melanoma model and cytomegalovirus-thymidine kinase expressing stem cells, demonstrating clear therapeutic effects." 11/20/1998 - "We performed a dose-escalating phase I/II study of retrovirus-mediated herpes simplex virus type 1 thymidine kinase (HSV-1-TK) suicide gene therapy for metastatic melanoma. " 11/20/1998 - "A phase I/II dose-escalation study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for metastatic melanoma. " 04/01/1996 - "The aim of the study was to use a virus-free system to transfer the Herpes Simplex Virus-thymidine kinase (HSV-TK) gene in mice bearing melanoma tumours. " 04/01/1996 - "Direct gene transfer of a plasmid carrying the herpes simplex virus-thymidine kinase gene (HSV-TK) in transplanted murine melanoma: in vivo study."

Related Drugs and Biologics

1.	Ganciclovir (Cytovene)
2.	Acyclovir (Aciclovir)
3.	Cytosine Deaminase
4.	Interleukin-2 (IL2)
5.	Liposomes (Liposome)
6.	DNA (Deoxyribonucleic Acid)
7.	Carcinoembryonic Antigen
8.	Vaccines
9.	Interleukin-4 (Interleukin 4)
10.	Luciferases

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Injections
3.	Drug Therapy (Chemotherapy)
4.	Transplants (Transplant)
5.	Transplantation (Transplant Recipients)