[Action of regulators of peripheral cholinergic processes on development of early arrhythmia in myocardial ischemic rats].

Abstract

Occlusion of the left coronary artery in rats provoked ventricular tachycardia (VT) and ventricular fibrillation (VF) within the first 30 min of ischemia leading to death in 20% animals. Methacin (i.v., 100 micrograms/kg) significantly prolonged VT and VF without effects on the survival. Acetylcholine (i.v., 10 micrograms/kg/min) had no influence on VT frequency and severity but prevented VF. Rats from this group survived. The same effect was observed for neostigmine (i.v., 25 micrograms/kg). Nicotine (i.v., 2.5 micrograms/kg/min) prolonged VT episode duration but did not change frequency and severity of VF and survival. Ganglioblockers hexametony and azametony (i.v., both in a dose 500 micrograms/kg) significantly attenuated VT, prevented VF and death of the animals. Thus, cholinotropic drugs may have both antiarrhythmic and proarrhythmogenic effects in early arrhythmias induced by ischemia.

• Authors: N A Losev, V V Eliseev, N S Sapronov, I B Krylova, N R Evdokimova
• Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia (Patol Fiziol Eksp Ter) 2002 Jan-Mar Issue 1 Pg. 14-6 ISSN: 0031-2991 [Print] Russia (Federation)
• Vernacular Title: Vliianie reguliatorov perifericheskikh kholinergicheskikh protsessov na razvitie rannikh aritmiĭ u krys pri ishemii miokarda.
• PMID: 11998397 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cholinergic Agents
• Cholinesterase Inhibitors
• Ganglionic Blockers
• Muscarinic Antagonists
• Quaternary Ammonium Compounds
• Neostigmine
• Hexamethonium
• pentamine
• Nicotine
• Oxyphenonium
• Acetylcholine

Topics

• Acetylcholine (pharmacology)
• Animals
• Arrhythmias, Cardiac (chemically induced, prevention & control)
• Cholinergic Agents (pharmacology)
• Cholinesterase Inhibitors (pharmacology)
• Ganglionic Blockers (pharmacology)
• Hexamethonium (pharmacology)
• Male
• Muscarinic Antagonists (pharmacology)
• Myocardial Ischemia (complications, drug therapy, physiopathology)
• Neostigmine (pharmacology)
• Nicotine (pharmacology)
• Oxyphenonium (pharmacology)
• Quaternary Ammonium Compounds (pharmacology)
• Rats
• Tachycardia (chemically induced)
• Ventricular Fibrillation (chemically induced)