Abstract | BACKGROUND: METHODS: RESULTS: Plasma and mucosal PGE2 demonstrated in ulcerative colitis exceeded control level over five and three fold respectively. They increased depending on the scored degree of mucosal injury, demonstrated through significant positive correlation (r = 0.437 and r = 0.525). Among other possible laboratory markers of the disease activity, only sedimentation rate revealed significant correlation (r = 0.288). CRP demonstrated weak association with the disease activity and there was almost lack of any association in respect to white blood count, and albumin or gamma-globulin concentrations. CONCLUSION: These data confirm possible usefulness of plasma or mucosal PGE2 measurement in patients with ulcerative colitis as a possible marker of inflammation. Moreover, as a prognostic factor it can reduce the number of endoscopic procedures.
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Authors | A Wiercińska-Drapało, R Flisiak, D Prokopowicz |
Journal | Roczniki Akademii Medycznej w Bialymstoku (1995)
(Rocz Akad Med Bialymst)
Vol. 46
Pg. 60-8
( 2001)
Poland |
PMID | 11780581
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Inflammation Mediators
- Dinoprostone
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Topics |
- Adult
- Aged
- Biomarkers
(analysis, blood)
- Colitis, Ulcerative
(blood, diagnosis, metabolism)
- Dinoprostone
(blood, metabolism)
- Female
- Humans
- Inflammation Mediators
(blood, metabolism)
- Intestinal Mucosa
(metabolism)
- Male
- Middle Aged
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