gamma-Globulins (gamma-Globulin)

Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.

Also Known As:

Networked: 2495 relevant articles (123 outcomes, 176 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yokota, Shumpei: 4 articles (02/2007 - 01/2004)
2.	Liu, Fang: 3 articles (11/2013 - 08/2005)
3.	Ito, Shuichi: 3 articles (11/2012 - 01/2004)
4.	Stypułkowska-Misiurewicz, Hanna: 3 articles (01/2011 - 01/2009)
5.	Cray, Carolyn: 3 articles (08/2010 - 03/2008)
6.	Motobu, Maki: 3 articles (02/2007 - 01/2003)
7.	Koge, Kenji: 3 articles (02/2007 - 01/2003)
8.	El-Abasy, Moshira: 3 articles (02/2007 - 01/2003)
9.	Hirota, Yoshikazu: 3 articles (02/2007 - 01/2003)
10.	Morita, Keiko: 3 articles (03/2006 - 09/2002)

Related Diseases

1.	Mucocutaneous Lymph Node Syndrome (Kawasaki Disease) 04/01/2003 - "Following the standard treatment with intravenous gamma globulin, the initial symptoms and signs of Kawasaki disease resolved completely. " 03/01/1995 - "However, high-dose intravenous gamma-globulin (IVGG) is a safe and effective treatment for Kawasaki disease. " 08/07/1986 - "We conclude that high-dose intravenous gamma globulin is safe and effective in reducing the prevalence of coronary-artery abnormalities when administered early in the course of Kawasaki syndrome." 08/01/2000 - "We evaluated the efficacy of intravenous gamma-globulin (IVGG) administration for children with Kawasaki disease to establish whether additional, more advanced therapy is needed in intractable cases. " 06/06/1991 - "In children with acute Kawasaki disease, a single large dose of intravenous gamma globulin is more effective than the conventional regimen of four smaller daily doses and is equally safe."
2.	Infection 01/01/1982 - "Transfer of intact human gamma globulin (GG) was effective in controlling infection. " 01/01/1985 - "Protective effects of human gamma-globulin preparations against experimental aerosol infections of mice with Bordetella pertussis." 06/01/1984 - "[Protective effects of human gamma globulin preparations against experimental aerosol infections of mice with Bordetella pertussis]." 11/01/1980 - "S-sulfonated gamma globulin (GGS), newly developed as a safe drug for intravenous use, was studied for its protective effects against some experimental infections in mice. " 11/01/1980 - "Protective effects of S-sulfonated human gamma globulin against experimental infections in mice."
3.	Thrombocytopenia (Thrombopenia) 04/01/1998 - "Severe thrombocytopenia (platelets < 50,000/microL) was seen in three infants despite successful therapy with high-dose gamma globulin prior to delivery, which elevated maternal platelet counts. " 05/01/1996 - "Antenatal management of alloimmune thrombocytopenia with intravenous gamma-globulin: a randomized trial of the addition of low-dose steroid to intravenous gamma-globulin." 12/01/2012 - "Her child suffered thrombocytopenia (4 × 10(9)/L) one month after he was born, then recovered after high-dose gamma globulin therapy. " 02/15/1999 - "All patients were treated with intravenous gamma globulin with a transient recovery of thrombocytopenia in two cases and a sustained recovery in another. " 06/01/1997 - "The children had transient severe thrombocytopenia in the newborn period, and were treated with intravenous gamma-globulin and platelet concentrates from random donors. "
4.	Hepatitis 10/02/1948 - "Methods of protection against homologous serum hepatitis; studies on the protective value of gamma globulin in homologous serum hepatitis Sh virus." 06/01/2000 - "Intravenous gamma globulins subsequently improved their condition, without biological worsening of viral hepatitis. " 11/17/1982 - "Specific gamma globulins (Uman-Big) were given at a dose of 0.06 cc/kg at intervals of 90-105 days, together with 0.02 cc/kg standard gamma globulins for conjectured protection against non-A and non-B hepatitis. " 06/01/1971 - "The incidence of posttransfusion hepatitis, and the lack of efficacy of gamma globulin in its prevention." 04/27/1968 - "[Gamma globulin for protection against epidemic hepatitis. "
5.	Hemorrhage 02/11/2010 - "Treatment of the SCID mouse recipients with intravenous gamma-globulins raised platelet counts and completely prevented bleeding mortality induced by antibody-mediated effector mechanisms but did not affect cell-mediated disease. " 06/01/1993 - "He remained well for several months when bleeding recommenced and he again responded promptly to gamma-globulin. " 02/01/1993 - "Intravenous gamma globulin was used in three patients, two of whom were bleeding. " 10/17/1992 - "If bleeding complications occur, high-dose human gamma-globulins are indicated. " 03/30/1984 - "Intravenous gamma globulin arrested massive gastrointestinal bleeding and allowed the patient to undergo surgical resection of the small bowel with minimal operative blood loss."

Related Drugs and Biologics

1.	Aspirin (Acetylsalicylic Acid)
2.	Immunoglobulin G (IgG)
3.	Inosine Triphosphate (ITP)
4.	Intravenous Immunoglobulins (IVIG)
5.	Adrenal Cortex Hormones (Corticosteroids)
6.	gamma-Globulins (gamma-Globulin)
7.	Anti-Bacterial Agents (Antibiotics)
8.	Cytokines
9.	Methylprednisolone
10.	Prednisone (Sone)

Related Therapies and Procedures

1.	Platelet Transfusion (Blood Platelet Transfusions)
2.	Oral Administration
3.	Plasma Exchange
4.	Transplants (Transplant)
5.	Intravenous Infusions