Abstract |
Proliferation of breast and endometrial cells is under the control of ovarian steroid hormones (SHs) such as oestrogen and progesterone. They mediate diverse physiological functions via interaction with nuclear-localised steroid hormone receptors (HRs). The SH receptor complex modifies the expression of SH-regulated genes by binding to conserved binding sites in their promoter region or through cross-talk with other transcription factors. In non-malignant tissues, HRs are in balance with other factors regulating proliferation, differentiation and apoptosis. While dysfunction of the regulatory mechanisms is a part of malignant transformation, functional SH receptors can promote growth of SH-responsive tumours. Therefore, anti- hormones that block the interaction of steroid hormones with the SH receptor are useful tools for the treatment of SH-responsive carcinomas. However, a portion of ER-positive breast cancers and most endometrial cancers do not respond to anti-oestrogens and continued treatment results in hormone resistance, mostly without loss of the ER. This review focuses on the mechanisms of action of hormones and anti- hormones in breast and endometrial carcinomas.
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Authors | T Flötotto, S Djahansouzi, M Gläser, B Hanstein, D Niederacher, C Brumm, M W Beckmann |
Journal | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
(Horm Metab Res)
Vol. 33
Issue 8
Pg. 451-7
(Aug 2001)
ISSN: 0018-5043 [Print] Germany |
PMID | 11544557
(Publication Type: Journal Article, Review)
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Chemical References |
- Estrogen Receptor Modulators
- Estrogens
- Hormone Antagonists
- Hormones
- Receptors, Estrogen
- Receptors, Steroid
- Steroids
- Transcription Factors
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Topics |
- Animals
- Binding Sites
(physiology)
- Breast Neoplasms
(drug therapy, metabolism)
- Disease Progression
- Endometrial Neoplasms
(drug therapy, metabolism)
- Estrogen Receptor Modulators
(metabolism, therapeutic use)
- Estrogens
(metabolism)
- Female
- Gene Expression
(physiology)
- Hormone Antagonists
(metabolism)
- Hormones
(metabolism)
- Humans
- Receptor Cross-Talk
(physiology)
- Receptors, Estrogen
(metabolism)
- Receptors, Steroid
(metabolism)
- Steroids
(metabolism)
- Transcription Factors
(metabolism)
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