[Interferon therapy to chronic hepatitis type C for the prevention of hepatocarcinogenesis].

Abstract

Interferon(IFN) therapy for chronic hepatitis(CH) related by hepatitis C virus is useful for the prevention of the appearance of hepatocellular carcinoma(HCC) by both prospective and retrospective study. IFN could be reduced an activity of necro-inflammatory reaction leading toward the reduction of fibrogenesis. Therefore, IFN treated group had a low potential carcinogenesis of the liver indicating the prevention of HCC from CH type C, even if virological complete remmision(CR) could not be obtained after IFN treatment. Biochemical response(BR) group as well as CR group could be inhibited hepatocarcinogenesis compare with non-IFN treated group. Recently, IFN applied for liver cirrhosis as same concept for the prevention of HCC.

• Authors: T Ichida, S Ohkoshi, M Takimoto, T Ishikawa
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 59 Issue 7 Pg. 1331-7 (Jul 2001) ISSN: 0047-1852 [Print] Japan
• PMID: 11494547 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Interferons

Topics

• Carcinoma, Hepatocellular (etiology, prevention & control)
• Clinical Trials as Topic
• Hepatitis C, Chronic (complications, drug therapy)
• Humans
• Interferons (therapeutic use)
• Liver Neoplasms (etiology, prevention & control)
• Multicenter Studies as Topic
• Neoplasm Recurrence, Local (prevention & control)
• Prospective Studies
• Retrospective Studies