Abstract |
Several aryl and heteroaryl hydrazides were synthesized and evaluated for their inhibitory effects on glutamic acid decarboxylase (GAD), GABA- alpha-oxoglutarate aminotransferase (GABA-T), and monoamine oxidase ( MAO) enzyme systems in chick brain 24 h after their intramuscular administration (0.75 mmol/kg). All compounds produced a reduction in GAD, GABA-T, and MAO activity. Structure-activity relationships indicated that the ring structure had a greater influence on the degree of GAD and GABA-T inhibition than did the N'-terminal group. In contrast, structural requirements for MAO inhibition were much more restrictive. The intramuscular administration of benzoic acid hydrazide to chicks 24 h prior to their being exposed to oxygen at high pressure provided significant protection against the onset of the hyperbaric oxygen-induced seizures.
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Authors | J D Wood, D K Gorecki, J R Dimmock, E M Hawes |
Journal | Canadian journal of physiology and pharmacology
(Can J Physiol Pharmacol)
Vol. 53
Issue 1
Pg. 47-55
(Feb 1975)
ISSN: 0008-4212 [Print] Canada |
PMID | 1139448
(Publication Type: Journal Article)
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Chemical References |
- Anticonvulsants
- Benzoates
- Glutamates
- Hydrazines
- Ketoglutaric Acids
- Monoamine Oxidase Inhibitors
- gamma-Aminobutyric Acid
- Transaminases
- Carboxy-Lyases
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Topics |
- Animals
- Animals, Newborn
- Anticonvulsants
(pharmacology)
- Benzoates
- Brain
(drug effects, enzymology)
- Carboxy-Lyases
(antagonists & inhibitors)
- Chickens
- Glutamates
- Hydrazines
(pharmacology)
- Hyperbaric Oxygenation
- Ketoglutaric Acids
- Monoamine Oxidase Inhibitors
(pharmacology)
- Structure-Activity Relationship
- Transaminases
(antagonists & inhibitors)
- gamma-Aminobutyric Acid
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