Isotypes of anti-beta2-glycoprotein I antibodies: association with thrombosis in patients with systemic lupus erythematosus.

Abstract

OBJECTIVE:

To evaluate the association between isotypes of anti-beta2-glycoprotein I antibodies (anti-beta2-GPI) and thrombosis and to identify antiphospholipid antibodies (aPL) that are most associated with thrombosis in patients with systemic lupus erythematosus (SLE).

METHODS:

IgG anticardiolipin antibody (aCL) and isotypes of anti-beta2-GPI were measured by ELISA, and clinical evidence of thrombosis was analyzed in 270 patients with SLE.

RESULTS:

IgG, IgM, and IgA anti-beta2-GPI were positive in 38.1, 13.7, and 34.8% of patients, respectively. Patients with a history of thrombosis were significantly more likely to have lupus anticoagulant (LAC), IgG aCL, and the 3 anti-beta2-GPI isotypes. Arterial thrombosis was associated with the presence of IgG aCL and the 3 anti-beta2-GPI isotypes, whereas venous thrombosis was associated with LAC, IgG aCL, and IgA anti-beta2-GPI. In stepwise multivariate logistic regression analysis, the variable that was associated with thrombosis was IgA anti-beta2-GPI. The occurrence of arterial thrombosis was associated with IgG aCL and that of venous thrombosis was related to IgA anti-beta2-GPI in stepwise multivariate analysis. The IgG, IgM, and IgA anti-beta2-GPI titers were closely correlated with IgG aCL titers. The IgA anti-beta2-GPI titers were also significantly correlated with those of IgG and IgM anti-beta2-GPI.

CONCLUSION:

The results suggest that anti-beta2-GPI isotypes are related to the occurrence of thrombosis, and measurements of IgA anti-beta2-GPI may be useful for predicting thrombotic episodes in patients with SLE.

• Authors: S S Lee, M L Cho, Y S Joo, W U Kim, Y S Hong, J K Min, S H Lee, S H Park, C S Cho, H Y Kim
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 28 Issue 3 Pg. 520-4 (Mar 2001) ISSN: 0315-162X [Print] Canada
• PMID: 11296952 (Publication Type: Journal Article)

Chemical References

• Antibodies, Antiphospholipid
• Glycoproteins
• Immunoglobulin A
• Immunoglobulin G
• Immunoglobulin M
• beta 2-Glycoprotein I

Topics

• Antibodies, Antiphospholipid (blood)
• Glycoproteins (immunology)
• Humans
• Immunoglobulin A (blood)
• Immunoglobulin G (blood)
• Immunoglobulin M (blood)
• Lupus Erythematosus, Systemic (complications, immunology)
• Thrombosis (etiology, immunology)
• beta 2-Glycoprotein I