Abstract | BACKGROUND: OBJECTIVE: We sought to determine whether there is an association between total and specific IgE to a variety of allergens in polyp and nonpolyp tissue and markers of eosinophilic inflammation or skin test results. METHODS: RESULTS: The concentrations of total IgE, IL-5, eotaxin, ECP, LTC4/D4/E4, and sCD23 were significantly higher in NP tissue compared with nonpolyp tissue. Total IgE was significantly correlated to IL-5, ECP, LTC4/D4/E4, and sCD23 and to the number of eosinophils in NPs. On the basis of the presence of specific IgE antibodies in tissue, 3 NP groups were defined. NP group 1 demonstrated no measurable specific IgE, and NP group 2 selected specific IgE. The third group demonstrated a multiclonal specific IgE, including IgE to S aureus enterotoxins, a high total IgE level, and a high prevalence of asthma. CONCLUSIONS: These studies suggest that there is an association between increased levels of total IgE, specific IgE, and eosinophilic inflammation in NPs, which may be of relevance in the pathophysiology of nasal polyposis. Similarly, the presence of specific IgE to staphylococcal enterotoxins A and B also points to a possible role of bacterial superantigens.
|
Authors | C Bachert, P Gevaert, G Holtappels, S G Johansson, P van Cauwenberge |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 107
Issue 4
Pg. 607-14
(Apr 2001)
ISSN: 0091-6749 [Print] United States |
PMID | 11295647
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Receptors, IgE
- Superantigens
- Interleukin-4
- Immunoglobulin E
|
Topics |
- Eosinophils
(physiology)
- Humans
- Immunoglobulin E
(analysis)
- Immunohistochemistry
- Inflammation
(immunology)
- Interleukin-4
(analysis)
- Nasal Polyps
(immunology)
- Receptors, IgE
(analysis)
- Staphylococcus aureus
(immunology)
- Superantigens
(immunology)
|