Effect of fensuccinal on experimental insulin resistance.

Abstract	The effects of new antioxidant fensuccinal on dexamethasone-induced insulin resistance in rats were studied. Oral administration of fensuccinal in a dose of 25 mg/kg for 2 weeks prevented basal hyperinsulinemia and insulin insensitivity of peripheral tissues. Fensuccinal also attenuated oxidative stress by decreasing the concentrations of primary and secondary lipid peroxidation products in liver homogenates. The ability of fensuccinal to prevent dexamethasone-induced insulin resistance is probably due to its antioxidant properties.
Authors	N I Gorbenko, V V Poltorak, A I Gladkikh, O V Ivanova
Journal	Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 130 Issue 7 Pg. 647-8 (Jul 2000) ISSN: 0007-4888 [Print] United States
PMID	11140576 (Publication Type: Journal Article)
Chemical References	Aldehydes Antioxidants Blood Glucose fensuccinal Dexamethasone
Topics	Aldehydes (pharmacology) Animals Antioxidants (pharmacology) Blood Glucose (analysis) Dexamethasone (adverse effects) Insulin Resistance Lipid Peroxidation (drug effects) Male Rats Rats, Wistar

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