Myositis and interstitial lung disease associated with autoantibody to a transfer RNA-related protein Wa.

Abstract

We describe 2 patients with myositis and interstitial lung disease with the autoantibody to Wa antigen, a 48-kDa transfer RNA-related protein. In contrast to the previous description of anti-Wa antibody, our patients lacked systemic sclerosis-related features, but had clinical features consistent with those associated with antibodies to aminoacyl-transfer RNA synthetases. The difference in clinical presentation between our patients and patients with systemic sclerosis may be explained by recognition of different epitopes on the Wa antigen.

• Authors: M Kajihara, M Kuwana, H Tokuda, K Yamane, M Kubo, M Hirakata, T Mimori
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 27 Issue 11 Pg. 2707-10 (Nov 2000) ISSN: 0315-162X [Print] Canada
• PMID: 11093458 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Autoantigens
• Wa antigen

Topics

• Aged
• Autoantibodies (analysis)
• Autoantigens (immunology)
• Female
• Humans
• Immunoblotting
• Lung Diseases, Interstitial (immunology)
• Male
• Middle Aged
• Myositis (immunology)
• Precipitin Tests
• Scleroderma, Systemic (immunology)