Abstract | OBJECTIVE: DESIGN: Controlled clinical study. SETTING: Healthy volunteers in an academic setting. PATIENT(S): Group 1 comprised 10 nonpregnant women; group 2, 10 first-trimester primigravid women; group 3, 10 first-trimester primigravid women suffering spontaneous abortion; and group 4, 10 first-trimester pregnant women with a history of miscarriage. All women were pregnant at the time of sampling, but 5 miscarried later in the first trimester. INTERVENTION(S): None of the patients received any medication. MAIN OUTCOME MEASURE(S): Serum levels of IL-10 and IFN-gamma. RESULT(S): Levels of IL-10 were significantly raised in normal pregnancy. Levels of IFN-gamma were raised in the recurrent-miscarriage group as compared with normal pregnancy. When patients in group 4 were divided into those whose pregnancies went to term and those who miscarried, we found that successful pregnancy was associated with a statistically significant increase in IL-10, whereas miscarriage was associated with significantly increased levels of IFN-gamma. CONCLUSION(S): These results support the view that miscarriage is associated with a T(H) 1 type response.
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Authors | C Jenkins, J Roberts, R Wilson, M A MacLean, J Shilito, J J Walker |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 73
Issue 6
Pg. 1206-8
(Jun 2000)
ISSN: 0015-0282 [Print] United States |
PMID | 10856484
(Publication Type: Journal Article)
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Chemical References |
- Interleukin-10
- Interferon-gamma
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Topics |
- Abortion, Habitual
(blood, metabolism)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Interferon-gamma
(blood, metabolism)
- Interleukin-10
(blood, metabolism)
- Pregnancy
- Reference Values
- Th1 Cells
(metabolism)
- Th2 Cells
(metabolism)
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