Abstract | UNLABELLED: RESULTS: The 8-OHdG content in the circulating leukocytes correlated with that of liver tissue (r = 0.618, p < .0004). HCV patients had the highest median 8-OHdG levels (p < .0004). 8-OHdG leukocyte levels in HCV patients were higher than in HBV patients (p < .04) and they significantly correlated with the clinical diagnosis (p < .025), the serum ferritin levels (p < .05), and the amount of liver steatosis (p < .001). No correlation was found with age, gender, history of drinking or smoking, ALT or GGT levels, ESR, alpha-1, or gamma-globulin level and Ishak score. TBARS levels were significantly higher in cirrhotics than in noncirrhotics (p < .01). CONCLUSIONS: The 8-OHdG level in circulating leukocytes is a reliable marker of oxidative stress occurring in the liver of individuals with chronic HCV infection. DNA oxidative damage appears to be an early and unique event in the natural history of HCV-related hepatitis. This injury increases the risk of genomic damage and may be one of the important factors involved in the carcinogenic process in cases of HCV-related chronic liver disease.
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Authors | F Farinati, R Cardin, P Degan, N De Maria, R A Floyd, D H Van Thiel, R Naccarato |
Journal | Free radical biology & medicine
(Free Radic Biol Med)
Vol. 27
Issue 11-12
Pg. 1284-91
(Dec 1999)
ISSN: 0891-5849 [Print] United States |
PMID | 10641722
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Thiobarbituric Acid Reactive Substances
- 8-Hydroxy-2'-Deoxyguanosine
- DNA
- Ferritins
- Deoxyguanosine
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Topics |
- 8-Hydroxy-2'-Deoxyguanosine
- Adult
- Aged
- DNA
(analysis, blood)
- DNA Damage
- Deoxyguanosine
(analogs & derivatives, analysis, blood)
- Fatty Liver
(blood)
- Female
- Ferritins
(blood)
- Hepatitis C, Chronic
(blood, genetics, metabolism)
- Humans
- Leukocytes
(chemistry)
- Lipid Peroxidation
- Liver
(chemistry)
- Liver Cirrhosis
(metabolism)
- Male
- Middle Aged
- Oxidation-Reduction
- Thiobarbituric Acid Reactive Substances
(metabolism)
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