Ferritins (Ferritin)

Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.

Also Known As:

Networked: 5852 relevant articles (152 outcomes, 752 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Adams, Paul C: 33 articles (05/2015 - 07/2002)
2.	Barton, James C: 27 articles (05/2015 - 04/2003)
3.	Gordeuk, Victor R: 24 articles (12/2014 - 11/2003)
4.	Acton, Ronald T: 23 articles (03/2015 - 01/2005)
5.	McLaren, Christine E: 22 articles (04/2015 - 01/2005)
6.	McLaren, Gordon D: 21 articles (07/2013 - 01/2005)
7.	Cunha, Burke A: 20 articles (05/2015 - 10/2004)
8.	Arosio, Paolo: 18 articles (07/2015 - 03/2002)
9.	Fargion, Silvia: 17 articles (01/2015 - 10/2003)
10.	Eckfeldt, John H: 16 articles (07/2013 - 04/2005)

Related Diseases

1.	Iron Overload 06/01/2014 - "This study shows that DFX is effective in reducing S-ferritin and LIC level in transfusional iron overload patients with MDS or AA and is well tolerated. " 03/01/2014 - "Eighteen months later, serum ferritin was reduced to 680 μg/L, while both liver and cardiac MRI T2* values improved, reflecting lower iron overload. " 01/01/2015 - "The present study aimed to fill that gap and assess the value of ferritin in the diagnosis of iron overload and deficiency. " 08/29/2013 - "Future studies in this population should use LIC to define iron overload instead of ferritin. " 09/01/2012 - "Recent studies using T2* MRI revealed that serum ferritin does not reflect the severity of iron overload in nontransfused TI patients. "
2.	Anemia 10/01/2015 - "The serum EPO is involved in the process of erythrocyte hematopoiesis, and can indicate the level of anemia, its sensitivity for anemia is higher than that of ferritin, and has important clinical value for evaluating status of diseases, observing therapeutic efficacy and judging prognosisi of IDA." 03/01/2006 - "Both MMN and FFA supplements were effective for preventing or treating anemia in Cambodian infants and stabilizing plasma levels of ferritin. " 04/20/2014 - "The criteria for study selection were: enrolment of patients with complicated anemia; bone marrow examination used as diagnostic gold standard for IDA; evaluation of sTfR vs. ferritin and binary data presentation. " 11/01/2015 - "During the period from pre- to postfortification (and as difference-in-difference for those studies that included a control group), there were statistically significant decreases in the prevalence of anemia in 4 of 13 subgroups of children and in 4 of 12 subgroups of women of reproductive age as well as significant decreases in the prevalence of low ferritin in 1 of 6 subgroups of children and in 3 of 3 subgroups of women of reproductive age. " 04/20/2014 - "Well-designed studies are still needed to define the added value, if any, of sTfR to ferritin for IDA detection in complicated anemia. "
3.	Infection 03/01/2011 - "However, those who had their infection eradicated at follow-up had a significantly larger increase in serum ferritin from baseline." 06/01/2004 - "To subclone and express the gene encoding Schistosoma japonicum ferritin (SjFer) and study its immune protection against challenge infection in mice vaccinated intranasally. " 03/01/2011 - "However, we found that those who had their infection eradicated had a 3-fold increased average change from baseline serum ferritin compared with that of children who remained infected (P < 0.05). " 01/01/2003 - "To test the immune protection against challenge infection in mice vaccinated intranasally or intragastrically with recombinant Schistosoma japonicum (S.j) Ferritin (rSjFer). " 01/01/2003 - "[Intranasal or intragastric vaccination of mice with recombinant Schistosoma japonicum ferritin induces immune protection against challenge infection]."
4.	Neoplasms (Cancer) 01/01/1993 - "Complete remission of cancer was correlated with normalization of CEA and NSE but not of ferritin levels. " 06/01/1986 - "The ferritin levels will, however, return to normal with clinical remission, suggesting that the tumor is the origin of the elevated ferritin. " 10/01/2014 - "Recent studies, further establishes ferritin as a multifunctional nanocarrier for targeted cancer diagnosis and therapy. " 02/01/2013 - "In this study, we comprehensively examined the distribution of ferritin in normal and malignant breast tissue at different stages in tumor development. " 01/01/2011 - "The study of leukocytes suggests that tumor cells of such patients contain compounds which can regulate production of HIF-1alpha, Hp and ferritin."
5.	Inflammation 10/14/2015 - "The present study further underlines the need to adjust for inflammation when serum sTfR and serum ferritin are used to assess Fe status in pregnancy." 07/01/2014 - "The pooled multivariable adjusted relative risks of T2D in the highest versus lowest quartile of ferritin levels were significantly elevated in both cross-sectional as well as prospective studies and after restriction to inflammation-adjusted studies [overall: 1.67 (95% CI 1.41-1.99)]. " 01/01/2014 - "we aimed to study the effects of inflammation on seminal ferritin (SF) levels and hypothesized that SF is not affected because of the testicular immune privilege. " 09/01/2010 - "In 2-group analyses (either CRP or AGP), we compared the ratios of log ferritin with or without inflammation in 30 studies. " 02/01/2008 - "This study was performed to determine any relationships between markers of OS, nutrition and inflammation in HD patients with normal and high ferritin levels. "

Related Drugs and Biologics

1.	Iron
2.	Hemoglobins (Hemoglobin)
3.	Transferrin (beta 2 Transferrin)
4.	Transferrin Receptors (Transferrin Receptor)
5.	Biological Markers (Surrogate Marker)
6.	Deferoxamine (Desferal)
7.	Zinc
8.	Alanine Transaminase (SGPT)
9.	Interferons
10.	C-Reactive Protein

Related Therapies and Procedures

1.	Chelation Therapy (Therapy, Chelation)
2.	Renal Dialysis (Hemodialysis)
3.	Drug Therapy (Chemotherapy)
4.	Transplantation (Transplant Recipients)
5.	Transplants (Transplant)