Cytochrome P-450 CYP3A Inducers

Drugs and compounds that induce the synthesis of CYTOCHROME P-450 CYP3A.

Also Known As:

CYP3A Inducers; CYP3A4 Inducers; CYP3A5 Inducers; CYP3A7 Inducers; Cytochrome P-450 CYP3A4 Inducers; Cytochrome P-450 CYP3A5 Inducers; Cytochrome P-450 CYP3A7 Inducers; P450 CYP3A Inducers; P450 CYP3A4 Inducers; P450 CYP3A5 Inducers; P450 CYP3A7 Inducers; CYP3A4 Inducers, P450; Cytochrome P 450 CYP3A Inducers; Cytochrome P 450 CYP3A4 Inducers; Cytochrome P 450 CYP3A5 Inducers; Cytochrome P 450 CYP3A7 Inducers; Inducer, CYP3A4; Inducers, CYP3A; Inducers, CYP3A4; Inducers, CYP3A5; Inducers, CYP3A7; Inducers, P450 CYP3A; Inducers, P450 CYP3A4; Inducers, P450 CYP3A5; Inducers, P450 CYP3A7; CYP3A4 Inducer

Networked: 25 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Cytochrome P-450 Enzyme Inducers: 5
      - Cytochrome P-450 CYP3A Inducers: 25
  - Metabolic Side Effects of Drugs and Substances: 5
    - Cytochrome P-450 Enzyme Inducers: 5
      - Cytochrome P-450 CYP3A Inducers: 25

Experts

1.	Cho, Yoon Sook: 2 articles (08/2020 - 10/2018)
2.	Gwak, Hye Sun: 2 articles (08/2020 - 10/2018)
3.	Han, Ji Min: 2 articles (08/2020 - 10/2018)
4.	Kim, Min Kyoung: 2 articles (08/2020 - 10/2018)
5.	Yee, Jeong: 2 articles (08/2020 - 10/2018)
6.	Bian, Xiao-Lan: 1 article (01/2022)
7.	Brown, Joshua D: 1 article (01/2022)
8.	Chaturvedula, Ayyappa: 1 article (01/2022)
9.	Chen, Bing: 1 article (01/2022)
10.	Cicali, Brian: 1 article (01/2022)

Related Diseases

1.	Pulmonary Embolism 01/01/2013 - "Use of carbamazepine, a CYP3A4 inducer, probably led to an increased clearance of rivaroxaban resulting in pulmonary embolisms. "
2.	Pruritus (Itching) 01/01/2018 - "Rifampicin, a potent CYP3A4 inducer, is the first-line treatment of cholestatic pruritus. "
3.	Bullous Pemphigoid (Pemphigoid) 01/01/2020 - "Refractory Bullous Pemphigoid Improved by Discontinuation of Phenytoin as an CYP3A4 Inducer."
4.	Neoplasm Metastasis (Metastasis) 08/01/2020 - "Close liver function monitoring is recommended, especially in patients with liver metastasis or using H2 blockers or CYP3A4 inducers." 08/01/2020 - "The use of H2 blockers, presence of liver metastasis, and CYP3A4 inducers were associated with high-grade hepatotoxicity of TKIs. " 08/01/2020 - "In patients who administrated TKIs which form reactive metabolites, use of CYP3A4 inducers and liver metastasis increased incidence of high-grade hepatotoxicity by 3.0- and 2.3-fold, respectively. " 10/16/2018 - "Liver metastasis and CYP3A4 inducers also shortened time to hepatotoxicity 2.1 and 2.3-fold, respectively. " 10/16/2018 - "Our study showed that concomitant use of CYP3A4 inducers and H2-antagonist/PPI, liver metastasis, and age ≥ 65 were associated with erlotinib-induced hepatotoxicity. "
5.	Hepatocellular Carcinoma (Hepatoma) 05/01/1996 - "In the present study we investigated CYP1A and CYP3A expression in the fish Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1) after coadministration of CYP1A and CYP3A inducers, including glucocorticoids. " 07/01/2013 - "Here, we report a pharmacokinetic interaction between sorafenib and the CYP3A4 inducer prednisolone in a patient with hepatocellular carcinoma (HCC). " 01/15/2000 - "Finally, in both chicken embryo liver and chicken hepatoma cells (LMH), CYP3A37 mRNA was increased after treatment with typical CYP3A inducers, such as metyrapone, phenobarbital, dexamethasone, and pregnenolone 16alpha-carbonitrile, but not rifampicin. "

Related Drugs and Biologics

1.	Rifampin (Rifampicin)
2.	Carbamazepine (Tegretol)
3.	Phenytoin (Dilantin)
4.	Rivaroxaban
5.	Cytochrome P-450 CYP3A
6.	Cytochrome P-450 CYP3A Inhibitors
7.	Glucocorticoids
8.	Antipsychotic Agents (Antipsychotics)
9.	Platinum
10.	Modafinil (Provigil)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Contraception (Birth Control)
3.	Aftercare (After-Treatment)
4.	Contraceptive Effectiveness