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Carbamazepine (Tegretol)

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An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.

Also Known As:

Tegretol; Epitol; Finlepsin; Neurotol; Amizepine; Carbamazepine Acetate; Carbamazepine Dihydrate; Carbamazepine Hydrochloride; Carbamazepine L-Tartrate (4:1); Carbamazepine Phosphate; Carbamazepine Sulfate (2:1); Carbazepin; Acetate, Carbamazepine; Dihydrate, Carbamazepine; Hydrochloride, Carbamazepine; Phosphate, Carbamazepine; 5H-Dibenz(b,f)azepine-5-carboxamide

Networked: 4845 relevant articles (537 outcomes, 672 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 3-Ring Heterocyclic Compounds
  - Dibenzazepines: 2
    - Carbamazepine: 4845

Experts

1.	Luszczki, Jarogniew J: 27 articles (09/2015 - 05/2003)
2.	Marson, Anthony G: 22 articles (11/2015 - 05/2002)
3.	Czuczwar, Stanisław J: 22 articles (06/2014 - 04/2002)
4.	Czuczwar, Stanislaw J: 20 articles (01/2012 - 06/2002)
5.	Ketter, Terence A: 16 articles (01/2008 - 06/2003)
6.	Perucca, Emilio: 15 articles (08/2015 - 01/2002)
7.	Pirmohamed, Munir: 14 articles (11/2015 - 04/2006)
8.	Rapoport, Stanley I: 13 articles (06/2009 - 07/2002)
9.	Borowicz, Kinga K: 12 articles (11/2008 - 04/2002)
10.	Tomson, Torbjörn: 11 articles (08/2015 - 06/2003)

Related Diseases

1.	Seizures (Seizure) 03/01/2013 - "Carbamazepine has been used as AEDs since 1965, and is most effective against partial seizures. " 07/01/2003 - "Carbamazepine is a well-established, effective treatment of complex partial seizures and is well tolerated in most patients. " 01/01/1984 - "Carbamazepine is highly effective in blocking completed amygdala-kindled seizures, but does not block their development in the rat. " 04/01/1979 - "Carbamazepine is an anticonvulsant most effective in treating complex partial and generalized tonic-clonic seizures. " 01/01/2014 - "Carbamazepine markedly improved her seizures. "
2.	Bipolar Disorder (Mania) 03/01/2005 - "Extended-release carbamazepine monotherapy had significantly greater efficacy compared with placebo in the treatment of acute mania in this large, randomized, double-blind, placebo-controlled trial." 01/01/2005 - "At study end, reductions from baseline in Young Mania Rating Scale scores were significantly greater with carbamazepine than with placebo (primary endpoint). " 04/01/1993 - "Although controlled trials have demonstrated the efficacy of carbamazepine for the treatment of rapid cycling bipolar disorder, the response to carbamazepine frequently deteriorates. " 02/01/2010 - "Carbamazepine is effective in treating symptoms of both mania and depression, and there are no significant differences in the relative efficacy of the IR or ERCC formulations." 01/01/2006 - "Recently, two large, 3-week, randomised, double-blind, placebo-controlled trials using nearly identical protocols demonstrated that monotherapy with carbamazepine extended-release capsules (CBZ-ERC) was effective for the treatment of acute mania in patients with bipolar I disorder. "
3.	Epilepsy (Aura) 11/01/2010 - "Compared with a 3.4% malformation incidence in women who took no AEDs (N = 118), the incidences for LTG (N = 243), carbamazepine (CBZ) (N = 302) and VPA (N = 224) were, respectively, 4.9%, 5.3% and 15.2%, the latter statistically significantly greater than the risk for no AED therapy in pregnant women with epilepsy. " 01/01/1985 - "Because of the favorable anticonvulsant and psychotropic efficacy of carbamazepine in the present study, coupled with the lack of serious side effects, it is recommended that the drug deserves wider use in African children with seizure disorders." 02/01/2006 - "Carbamazepine would appear to be a cost-effective treatment for epilepsy in certain contexts, although evidence from a prospective, randomized, controlled trial is awaited and this assertion may not be true for certain patient subgroups, or in developing world health services. " 09/01/1983 - "Carbamazepine is an anticonvulsant agent that has been found clinically useful in the treatment of refractory seizure disorders. " 01/01/2015 - "Whether VGB monotherapy is an effective and safe treatment compared with the standard antiepileptic drug carbamazepine (CBZ) as monotherapy for epilepsy has not been systematically reviewed. "
4.	Pain (Aches) 09/01/2015 - "The pain was not relieved significantly, even with the administration of carbamazepine. " 09/01/2014 - "Significant reduction of the pain was achieved with carbamazepine. " 01/01/2014 - "The patient was treated with carbamazepine with mild relief of pain and later on with botulinum injection, which significantly reduced the movements and mildly improved the pain. " 03/01/1998 - "Carbamazepine produced a statistically significant reduction in the pain scores, from 8.2 +/- 2.3 to 4.0 +/- 1.1 after the first treatment. " 01/01/2005 - "There is no evidence that carbamazepine is effective for acute pain. "
5.	Trigeminal Neuralgia (Tic Douloureux) 02/01/2015 - "Carbamazepine was found to be highly effective in trigeminal neuralgia. " 01/01/1985 - "Carbamazepine is considered the drug of choice and is initially very effective in treating trigeminal neuralgia. " 12/01/2014 - "Carbamazepine (CBZ) formed the gold standard drug in trigeminal neuralgia (TN) treatment but faces high therapeutic failure. " 01/01/1985 - "Trigeminal neuralgia was diagnosed, and carbamazepine therapy was initiated with good results. " 01/01/1997 - "Is carbamazepine less effective in the treatment of trigeminal neuralgia when prescribed by oral and maxillofacial surgeons?"

Related Drugs and Biologics

1.	Valproic Acid (Valproate, Semisodium)
2.	Phenytoin (Dilantin)
3.	Lithium
4.	lamotrigine (Lamictal)
5.	Anticonvulsants (Antiepileptic Drugs)
6.	Phenobarbital (Luminal)
7.	gabapentin (Neurontin)
8.	oxcarbazepine (Trileptal)
9.	topiramate (Topamax)
10.	Carbamazepine (Tegretol)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Hemoperfusion
3.	Psychology Biofeedback (Biofeedback)
4.	Vagus Nerve Stimulation
5.	Relaxation Therapy