Securin

Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.

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Networked: 135 relevant articles (1 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chao, Jui-I: 9 articles (09/2014 - 01/2006)
2.	Melmed, Shlomo: 9 articles (12/2012 - 03/2003)
3.	Chiu, Shu-Jun: 8 articles (12/2016 - 12/2006)
4.	Kakar, Sham S: 7 articles (12/2019 - 12/2003)
5.	Melmed, S: 6 articles (02/2014 - 11/2001)
6.	Wawrowsky, Kolja: 6 articles (12/2012 - 05/2005)
7.	Pintor-Toro, José A: 5 articles (11/2011 - 10/2002)
8.	Yu, Run: 5 articles (06/2009 - 03/2003)
9.	Kronqvist, Pauliina: 4 articles (06/2020 - 03/2012)
10.	Kuopio, Teijo: 4 articles (06/2020 - 03/2012)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 05/06/2017 - "In this study, we have performed a genome-wide analysis and identification of securin-binding partners in the gene diversity space of human colorectal cancer. " 05/06/2017 - "Systematic Identification and Competitive Disruption of Securin-Binding Partners in the Gene Diversity Space of Human Colorectal Cancer." 12/15/2007 - "As a whole, these findings suggest that the existence of securin promotes apoptosis via a p53-indpendent pathway after radiation in human colorectal cancer cells." 12/15/2007 - "Besides, the existence of securin in colorectal cancer cells induced higher apoptosis than the securin-null after radiation. " 12/15/2007 - "Expression of securin promotes colorectal cancer cell death via a p53-independent pathway after radiation."
2.	Neoplasms (Cancer) 09/16/2022 - "Hence, we performed a meta-analysis of published studies to assess the clinical value of securin expression in patients with solid cancers. " 09/16/2022 - "Numerous studies have investigated the clinical significance of securin expression in solid cancers; however, the results have been inconsistent. " 05/01/2015 - "Present study revealed that precocious anaphase and expression of p53 and Securin in non-target cells are significantly associated with an increased risk of RAN-induced cancer and thus these parameters can be of early diagnostic value. " 06/01/2010 - "This study investigated the role of securin in radiation-induced apoptosis and senescence in human cancer cells. " 09/16/2022 - "Consistently, our bioinformatics analysis showed that increased securin expression was associated with worse OS and shorter disease-free survival in cancer patients. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2013 - "In this study, we showed that radiation induced senescence in securin-deficient human breast cancer cells involving the ATM/Chk2 and p38 pathways. " 09/15/2009 - "In our study, securin predicted breast cancer-specific survival among all cases of invasive breast cancer and subgroups divided according to histological type, Ki-67 proliferation status and tumour size. " 06/01/2019 - "The present results suggest that securin may add to the prognostic value of ki67 in highlighting intra-tumoural heterogeneity in invasive breast carcinoma patients with poor clinical outcome. " 06/01/2019 - "Securin and ki67 immunohistochemical staining were performed on tissue microarray sections representative of 118 patients diagnosed with invasive breast carcinoma from 2005 to 2011. " 06/01/2019 - "To identify the role of securin (PTTG) as a prognostic marker in invasive breast carcinoma and its possible relation to ki67 and to evaluate the use of ImmunoRatio® as a tool for calculating ki67 and securin labelling indices. "
4.	Pituitary Neoplasms (Pituitary Adenoma) 07/01/2014 - "The objectives of this study were to generate immortalized MSCs derived from MSCs isolated from placenta (naive) by human TERT gene transfection with the AMAXA gene delivery system, to compare their characteristics, and to investigate whether increased TERT expression affected the pituitary tumor transforming gene (PTTG1; also known as securin), which is involved in chromosome segregation during mitosis. " 01/01/2022 - "RSUME regulates, through its post-translational (PTM) modification, pituitary tumor transforming gene (PTTG) protein stability in pituitary tumors. " 06/01/2019 - "The pituitary tumor-transforming gene 1 (PTTG1), also known as Securin, is considered an oncogene. " 03/07/2013 - "Human securin, also known as human pituitary tumor-transforming gene 1 (pttg1), plays a key role in cell-cycle regulation. " 12/01/2012 - "Pituitary tumor transforming gene (PTTG), the index human securin, a hallmark of pituitary tumors, triggers pituitary cell proliferation and murine pituitary tumor development. "
5.	Carcinogenesis 01/01/2018 - "Securin PTTG has a critical role in pituitary tumorigenesis. " 01/21/2014 - "Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis." 07/01/2010 - "Increased PTTG protein expression may be involved in the carcinogenesis and progression of RCCC." 10/01/2009 - "The pituitary tumour transforming gene (PTTG; securin) was the first transforming gene found to be highly expressed in pituitary tumour cells, and seems to play an important role in the process of oncogenesis. " 05/01/2007 - "We therefore speculated that the genes TTK, MAD2L1, BUB1, BUB1B and PTTG1 (Securin), jointly implicated in the regulation of mitotic checkpoint, might be associated with breast tumorigenesis. "

Related Drugs and Biologics

1.	6- methoxy- 3- (3',4',5'- trimethoxybenzoyl)- 1H- indole
2.	Proteins (Proteins, Gene)
3.	Biomarkers (Surrogate Marker)
4.	Ubiquitin-Specific Proteases
5.	Protein Isoforms (Isoforms)
6.	Survivin
7.	fisetin
8.	lime (calcium oxide)
9.	Cytochalasin B
10.	Chromatin

Related Therapies and Procedures

1.	Radiotherapy
2.	Therapeutics