Periostitis

Inflammation of the periosteum. The condition is generally chronic, and is marked by tenderness and swelling of the bone and an aching pain. Acute periostitis is due to infection, is characterized by diffuse suppuration, severe pain, and constitutional symptoms, and usually results in necrosis. (Dorland, 27th ed)

Also Known As:

Networked: 126 relevant articles (5 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Inflammation
3.	Pericarditis
4.	Lung Diseases (Lung Disease)
5.	Periodontitis

Experts

1.	Aksentijevich, Ivona: 2 articles (11/2013 - 12/2011)
2.	Yao, Qingping: 2 articles (10/2011 - 06/2009)
3.	Berdon, Walter E: 2 articles (12/2007 - 07/2003)
4.	Peters, Ove A: 1 article (01/2016)
5.	Guedes, Orlando Aguirre: 1 article (01/2016)
6.	Alencar, Ana Helena G: 1 article (01/2016)
7.	Estrela, Carlos: 1 article (01/2016)
8.	Estrela, Cyntia R A: 1 article (01/2016)
9.	Nunes, Carla A B C M: 1 article (01/2016)
10.	Wenke, Joseph C: 1 article (12/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Periostitis:

1.	voriconazole (Vfend)FDA LinkGeneric 12/01/2015 - "While resolution of clinical symptoms following discontinuation of therapy suggests a causative role for voriconazole, the biological mechanisms contributing to voriconazole-induced periostitis are unknown. " 12/01/2015 - "Fluffy Periostitis Induced by Voriconazole." 10/06/2015 - "Voriconazole-induced periostitis." 09/01/2015 - "Fluorosis and periostitis deformans as complications of prolonged voriconazole treatment." 03/01/2015 - "Case 215: voriconazole-induced periostitis."
2.	Alkaline PhosphataseIBA 12/01/2009 - "The diagnosis of periostitis was made by the documentation of bone pain, elevation of serum alkaline phosphatase and characteristic findings on radionuclide bone imaging in the absence of any identifiable rheumatologic disease. " 12/01/2013 - "However, upon further review, she had an elevated alkaline phosphatase and periostitis on her hip radiograph; voriconazole was held, and within 2 days she had marked improvement in her pain. " 12/01/2009 - "Awareness of this potential syndrome, which manifests as bone pain, elevated serum alkaline phosphatase and a bone scan suggestive of periostitis, is necessary in LT recipients on long-term voriconazole." 11/01/2014 - "Blood fluoride (P < .001), alkaline phosphatase (P = .020), daily voriconazole dose (P < .001), and cumulative voriconazole dose (P = .027) were significantly elevated in patients who had periostitis compared with those who did not. " 03/01/2011 - "Discontinuation of voriconazole therapy in patients with periostitis resulted in improvement of pain and a reduction in alkaline phosphatase and fluoride levels. "
3.	ChitosanIBA 01/01/2005 - "[Clinical-microbiological evaluation of the efficacy of combined use of chitosan, low intensity laser radiation and photosensitizer in treatment of patients with acute suppurative maxillofacial periostitis]."
4.	Alendronate (Alendronate Sodium)FDA LinkGeneric 05/01/2007 - "Unexplained, transient inflammation seemed to cause her pericarditis, restrictive lung disease, and periostitis with accelerated skeletal turnover that responded well to antiinflammatory drugs and alendronate therapy."
5.	CollagenIBA 04/01/1981 - "Collagen antibody titers were decreased and an improvement in only one radiologic parameter (periostitis) was detected. "
6.	infliximab (Remicade)FDA Link 10/01/2015 - "Childhood-onset psoriatic onycho-pachydermo-periostitis treated successfully with infliximab."
7.	nimesulide (Aulin)IBA 02/01/1989 - "A Polycentric Study was carried out so as to assess the anti-inflammatory effectiveness and pain-killing activity of Nimesulide in Odontostomatological practice, in 78 patients suffering from alveolo-gingival and parodontal abscesses, consequences of tooth extraction, suppurated radicular cysts, dysodontiasis, osteitis, periodontitis, periostitis. "
8.	4-hexyloxyaniline (HOA)IBA 10/01/2011 - "HOA was diagnosed in the presence of periostitis with the symptoms. " 06/01/2010 - "Hypertrophic osteoarthropathy (HOA) is characterized by periostitis of tubular bones, thickened skin, and digital clubbing. " 05/01/2010 - "This case indicates that HOA may manifest with isolated calcaneal periostitis bilaterally, which is a new addition to the literature." 12/01/2009 - "This periostitis appears similar to hypertrophic osteoarthopathy (HOA) but does not meet all criteria for HOA. " 06/01/2009 - "HOA, especially periostitis without clubbing, may go unrecognized. "
9.	FluoridesIBA 04/01/2014 - "Multiple painless masses: periostitis deformans secondary to fluoride intoxication." 01/01/1991 - "Periostitis due to low-dose fluoride intoxication demonstrated by bone scanning." 09/01/2015 - "Measurement of fluoride levels strongly supports fluorosis to be the mechanism of the voriconazole-induced periostitis deformans and supports the concept that such measurements might be of use in predicting this complication of long-term voriconazole treatment. " 11/01/2014 - "The trifluorinated molecular structure of voriconazole suggests a possible link between excess fluoride and periostitis, as elevated blood fluoride has been reported among patients with periostitis who received voriconazole. " 03/01/2011 - "The presentation more closely resembles periostitis deformans than hypertrophic osteoarthropathy, suggesting that the fluoride moiety of voriconazole may be pathogenic for this condition. "
10.	secondary SyphilisIBA 06/01/1994 - "Role of bone scintigraphy in the detection of periostitis in secondary syphilis." 09/01/1985 - "Two cases of secondary syphilis are reported with periostitis as the main presenting feature. " 09/01/1985 - "Periostitis in secondary syphilis: a place for bone scintigraphy." 07/01/1983 - "Subsequently, a skin eruption and VDRL result of 1:128 indicated that most of the findings could be explained by a diagnosis of secondary syphilis with luetic hepatitis and periostitis. " 03/01/1964 - "[SECONDARY SYPHILIS WITH MULTI-LACUNAR CRANIAL OSTEOLYSIS AND TIBIAL PERIOSTITIS]."

Therapies and Procedures

1.	Lasers (Laser) 01/01/2005 - "[Clinical-microbiological evaluation of the efficacy of combined use of chitosan, low intensity laser radiation and photosensitizer in treatment of patients with acute suppurative maxillofacial periostitis]."
2.	Tooth Extraction (Tooth Extractions) 01/01/1970 - "[Mandibular periostitis following tooth extraction from the maxilla]." 01/01/2013 - "It is shown that periodontitis remains till today the leading cause of tooth extraction in the elderly age; in addition, periodontitis can lead to serious complications such as periostitis, phlegmon, osteomyelitis, which creates additional scientific interest in the study of the above complications at the junction of the two specialties--gerontology and stomatology. " 02/01/1989 - "A Polycentric Study was carried out so as to assess the anti-inflammatory effectiveness and pain-killing activity of Nimesulide in Odontostomatological practice, in 78 patients suffering from alveolo-gingival and parodontal abscesses, consequences of tooth extraction, suppurated radicular cysts, dysodontiasis, osteitis, periodontitis, periostitis. "
3.	Traction 01/01/2003 - "CECS and bone stress injury or traction periostitis can occur separately or together." 02/20/1982 - "[Traction periostitis of the tibia]." 01/01/2009 - "The name given to this condition refers to pain on the posteromedial tibial border during exercise, with pain on palpation of the tibia over a length of at least 5 cm. Histological studies fail to provide evidence that MTSS is caused by periostitis as a result of traction. " 01/01/2003 - "Stress-related anterior lower leg pain can be related to CECS, bone stress injury, and traction periostitis. " 01/01/2003 - "Thirty-three exhibited bone stress injuries, and two exhibited leg traction periostitis. "
4.	Oral Medicine 01/01/2013 - "It is shown that periodontitis remains till today the leading cause of tooth extraction in the elderly age; in addition, periodontitis can lead to serious complications such as periostitis, phlegmon, osteomyelitis, which creates additional scientific interest in the study of the above complications at the junction of the two specialties--gerontology and stomatology. "
5.	Transplants (Transplant) 02/01/2011 - "Although drug-related periostitis has long been known, the association of lung transplant medication with periostitis was only recently introduced in the literature. " 02/01/2011 - "Medication-induced periostitis in lung transplant patients: periostitis deformans revisited." 09/01/2014 - "Voriconazole-related periostitis has been increasingly described in the literature over the last several years as a recognizable disease entity, especially in lung transplant patients. " 01/01/2014 - "Voriconazole-induced periostitis is a rare condition but had previously been reported in solid organ or patients with bone marrow transplant who received a long-term voriconazole therapy. " 08/01/2013 - "While drug-related periostitis has been known of for many years, the specific association of diffuse periostitis with voriconazole (most frequently in transplant patients) has only been recently explicitly addressed in the literature. "