Visceral Larva Migrans

A condition produced in man by the prolonged migration of animal nematode larvae in extraintestinal tissues other than skin; characterized by persistent hypereosinophilia, hepatomegaly, and frequently pneumonitis, commonly caused by Toxocara canis and Toxocara cati.

Also Known As:

Networked: 65 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Toxocariasis
2.	Eosinophilia
3.	Myiasis (Myiases)
4.	Granuloma
5.	Infection

Experts

1.	Rajapakse, R P V J: 2 articles (09/2008 - 03/2007)
2.	Agatsuma, Takeshi: 2 articles (09/2008 - 03/2007)
3.	Akao, Nobuaki: 2 articles (01/2006 - 11/2005)
4.	Nawa, Yukifumi: 2 articles (01/2006 - 03/2004)
5.	Bottieau, Emmanuel: 1 article (03/2015)
6.	Van Esbroeck, Marjan: 1 article (03/2015)
7.	Van Den Enden, Erwin: 1 article (03/2015)
8.	Clerinx, Jan: 1 article (03/2015)
9.	Van Den Ende, Jef: 1 article (03/2015)
10.	Vlieghe, Erika: 1 article (03/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Visceral Larva Migrans:

1.	AntigensIBA 09/01/2004 - "Ascaris suum larval excretory-secretory (AsES) antigen and larval (AsLA) as well as adult somatic antigen (AsAA) which were thought to be possibly helpful in the diagnosis of visceral larva migrans (VLM) due to A. " 07/01/2008 - "canis larvae and a simple method for the production of Toxocara ES antigen for the uses in serodiagnostic tests for visceral larva migrans. " 03/01/2007 - "Characterization of a Toxocara canis species-specific excretory-secretory antigen (TcES-57) and development of a double sandwich ELISA for diagnosis of visceral larva migrans." 09/01/2001 - "A Western blotting procedure with excretory/secretory antigens from Toxocara canis larvae was developed for immunodiagnosis of visceral larva migrans in mice. " 09/01/2001 - "Application of western blotting procedure for the immunodiagnosis of visceral larva migrans in mice by using excretory/secretory antigens."
2.	Thiabendazole (Mintezol)FDA Link 09/01/1979 - "Thiabendazole therapy is probably worth trying for early ophthalmic involvement with visceral larva migrans if the organism is still alive. " 02/01/1975 - "Thiabendazole treatment of presumptive visceral larva migrans (VLM)." 07/19/1971 - "Thiabendazole effects in visceral larva migrans." 03/01/1971 - "Thiabendazole in visceral larva migrans." 11/01/1969 - "Thiabendazole therapy in visceral larva migrans. "
3.	Hemagglutinins (Hemagglutinin)IBA 01/01/1985 - "These antigens may cross-react with elevated concentrations of A and B isohemagglutinins in some patients and give false-positive results in the serologic diagnosis of visceral larva migrans caused by T. " 01/01/1985 - "Do Toxocara canis larval antigens used in enzyme-linked immunosorbent assay for visceral larva migrans cross-react with AB isohemagglutinins and give false positive results?"
4.	AntibodiesIBA 01/01/2015 - "Immunoblot for the detection of Ascaris suum-specific antibodies in patients with visceral larva migrans (VLM) syndrome." 09/01/1993 - "The laboratory test results for visceral larva migrans (VLM) using ELISA for Toxocara canis antibodies employed by the Institute for Medical Research, Kuala Lumpur, is described. " 04/01/1977 - "Larva-specific antibodies in patients with visceral larva migrans." 04/01/2007 - "The aim of this investigation was to study the frequency of visceral larva migrans (VLM) granulomas in autopsies at a Children's Reference Hospital in Vitoria, ES Brazil, where anti-Toxocara antibodies are frequently detected in the serum of children admitted at the hospital. " 03/01/2015 - "Toxocariasis was considered as highly probable if serum Toxocara-antibodies were detected in combination with symptoms of visceral larva migrans if present, elevated eosinophil count in blood or other relevant fluid and reasonable exclusion of alternative diagnosis, or definitive in case of documented seroconversion. "
5.	Ivermectin (Mectizan)FDA Link 01/01/2005 - "Clinical trials are under way to evaluate the activity of ivermectin on nematodes (Loa loa, Mansonella sp., intestinal nematodes, cutaneous and visceral larva migrans) and ectoparasites (Pediculus humanus capitis, Phtirius pubis, Tunga penetrans, myiases). " 10/01/2001 - "Examples include thiabendazole for cutaneous larva migrans, mebendazole for ascariasis, trichiuriasis and hookworm, albendazole for inoperable cases of cystic hydatid disease, DEC for Toxocara induced visceral larva migrans and loiasis, ivermectin for onchocerciasis, praziquantel for schistosomiasis and niridazole for Dracunculus medinensis. "
6.	Interleukin-5 (Interleukin 5)IBA 01/01/1996 - "IL-5 drives eosinophils from bone marrow to blood and tissues in a guinea-pig model of visceral larva migrans syndrome." 01/01/1996 - "This study was undertaken to evaluate the role of IL-5 in eosinophil migration and in the maintenance of eosinophilia in a guinea-pig model of visceral larva migrans syndrome. "
7.	Immunoglobulin G (IgG)IBA 09/01/2008 - "Development of a highly sensitive IgG-ELISA based on recombinant arginine kinase of Toxocara canis for serodiagnosis of visceral larva migrans in the murine model." 01/01/2006 - "Eventually she transpired to have a high IgG antibody titer against excretory-secretary (ES) antigen of Ascaris suum larvae, but not of Toxocara canis larvae, suggesting that she had been suffering from visceral larva migrans (VLM) caused by A. " 09/01/1980 - "A 3-year-old girl had the typical features of visceral larva migrans syndrome, including hypereosinophilia, recurrent pulmonary infiltrates, and elevated serum IgG, IgE, and isohemagglutinin titers. " 04/01/2001 - "ELISA showed 10% with visceral larva migrans & 65.5% with toxoplasmosis (IgG, IgM or both). " 01/01/1982 - "In sera from patients with visceral larva migrans (VLM) syndrome, enzyme-linked immunospecific assay (ELISA) was used to detect IgG and IgE antibody anti-excretory-secretory antigen (ESA) from the second larval stage of Toxocara canis. "
8.	Immunoglobulin E (IgE)IBA 09/01/2014 - "IgE is a marker for visceral larva migrans." 01/01/2009 - "Two children aged 8 and 14 years respectively, with symptomatic ocular and visceral larva migrans syndromes, and one 16-year-old adolescent with chronic multifocal eye invasion, characterized by severe granulomatous retinochoroiditis with unilateral blindness, chronic abdominal pain and generalized synthesis of total immunoglobulin E antibody are described. " 07/01/1997 - "Toxocara (the cause of visceral larva migrans in humans) and allergy have in common both elevated immunoglobulin E (IgE) levels and eosinophilia. " 09/01/1980 - "A 3-year-old girl had the typical features of visceral larva migrans syndrome, including hypereosinophilia, recurrent pulmonary infiltrates, and elevated serum IgG, IgE, and isohemagglutinin titers. " 12/01/1969 - "Antibodies to Toxocara in the sera of visceral larva migrans patients: the significance of raised levels of IgE."
9.	Carbon MonoxideIBA 01/01/2009 - "The co-occurrence of Toxocara ocular and visceral larva migrans syndrome: a case series." 07/01/1969 - "Co-existing Guillarin-Barré and visceral larva migrans syndromes." 04/01/2003 - "We report a case of a cerebral and systemic vasculitis secondary to a visceral larva migrans syndrome associated with a Toxocara canis and Fasciola hepatica co-infestation."
10.	Adrenal Cortex Hormones (Corticosteroids)IBA 03/01/2004 - "Our results suggest that neurological involvement due to visceral larva migrans can be efficaciously treated with not only helminthic drugs but also intravenous corticosteroids." 02/01/1977 - "For example, in visceral larva migrans, caused by the dog roundworm Toxocara canis, only palliative therapy with systemic anti-inflammatory agents and corticosteroids may be helpful. " 03/01/2001 - "Therapy of ocular toxocariasis is primarily based upon corticosteroids use, when visceral larva migrans and few cases of common or covert toxocariasis can be treated by anthelmintics whose the most efficient appeared to be diethylcarbamazine. "

Therapies and Procedures

1.	Palliative Care (Palliative Medicine) 02/01/1977 - "For example, in visceral larva migrans, caused by the dog roundworm Toxocara canis, only palliative therapy with systemic anti-inflammatory agents and corticosteroids may be helpful. "
2.	Aftercare (After-Treatment) 04/01/1984 - "canis may account for the clinical improvement observed after treatment with thiabendazole in cases of visceral larva migrans, the prevention of prenatal or mammary transmission of infection in dogs, and the suppression of tissue damage by nematode larvae in general."