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Antidiarrheals

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Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition.

Also Known As:

Antidiarrheal Agents; Antidiarrheal Drugs; Antiperistaltic Agents; Antiperistaltic Drugs; Agents, Antidiarrheal; Agents, Antiperistaltic; Drugs, Antidiarrheal; Drugs, Antiperistaltic; Antiperistaltics

Networked: 99 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 56
  - Therapeutic Uses: 297
    - Gastrointestinal Agents: 33
      - Antidiarrheals: 99

Experts

1.	Benninga, Marc A: 2 articles (02/2015 - 01/2004)
2.	Cash, Brooks D: 2 articles (06/2011 - 05/2008)
3.	Verkman, A S: 2 articles (01/2006 - 08/2004)
4.	Galietta, Luis J V: 2 articles (01/2006 - 08/2004)
5.	O'Brien, Susan: 1 article (07/2015)
6.	Ravandi, Farhad: 1 article (07/2015)
7.	Badar, Talha: 1 article (07/2015)
8.	Kantarjian, Hagop: 1 article (07/2015)
9.	Verstovsek, Srdan: 1 article (07/2015)
10.	Cortes, Jorge E: 1 article (07/2015)

Related Diseases

1.	Diarrhea 03/01/1993 - "The higher efficacy against CT-induced hypersecretion as compared to PGE1-induced hypersecretion suggests a direct antisecretory effect at the enterocyte level and indicates the usefulness of these products as antidiarrheal agents in nonhormonally mediated diarrhea." 07/01/2015 - "Grade 1/2 diarrhea was the only frequent nonhematologic toxicity observed in 14 of 17 (82%) patients and was resolved with oral antidiarrheal agents. " 01/01/2015 - "Additionally, no significant difference was observed in the administration of intestinal regulators and antidiarrheal agents, but again the assessment score was lower in the HRB than control group, and diarrhea symptoms were alleviated with the oral intake of HRB. " 11/01/2014 - "Six patients (14.3%) experienced postoperative diarrhea requiring administration of antidiarrheal agents. " 11/01/2013 - "[Antidiarrheal drugs for chronic diarrhea]."
2.	Pain (Aches) 09/01/2012 - "Over-the-counter laxatives and antidiarrheals may improve stool frequency but not pain. " 02/01/2015 - "No studies were found concerning antidiarrheal agents, antibiotics, pain medication, anti-emetics, or antimigraine agents. " 01/01/2001 - "Dietary modifications like fiber supplementation, antidiarrheal agents and antispasmodic drugs are the basis of the current treatment of IBS and depend on the predominant symptom (constipation, diarrhea or pain, respectively). " 06/01/2004 - "Traditional symptomatic treatment has included antidiarrheals, laxatives and bulking agents/fiber, low-dose tricyclic antidepressants, antispasmodics for pain, and "alternative" therapies (e.g. " 01/01/2013 - "For example, the complex therapy of pain and other manifestations associated with irritable bowel syndrome include psychotherapy/behavioural therapy, bulk-forming agents, probiotics, laxatives, antidiarrheals, antibacterial agents, antispasmodics, and antidepressants. "
3.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 06/01/2011 - "The therapeutic options for irritable bowel syndrome are rapidly evolving beyond traditional symptom-based therapies, such as fiber, antispasmodics, antidiarrheals and laxatives, and are moving toward agents with organ-specific receptor selectivity directed, in many cases, at specific gastrointestinal functions." 05/01/2008 - "The therapeutic options for irritable bowel syndrome are rapidly evolving beyond traditional symptom-based therapies, such as fiber, antispasmodics, antidiarrheals and laxatives and are moving towards agents with organ-specific receptor selectivity directed, in many cases, at specific gastrointestinal functions." 12/01/2005 - "Over the past 30 years, the main treatment of irritable bowel syndrome has aimed to normalize gastrointestinal transit using either laxatives or antidiarrheal agents, with or without the concurrent use of spasmolytics. " 01/01/2013 - "For example, the complex therapy of pain and other manifestations associated with irritable bowel syndrome include psychotherapy/behavioural therapy, bulk-forming agents, probiotics, laxatives, antidiarrheals, antibacterial agents, antispasmodics, and antidepressants. " 11/01/1981 - "The major classes discussed are antiemetics, laxatives and antidiarrheal agents, antacids and cimetidine, drugs for irritable bowel syndrome, and drugs for inflammatory bowel disease. "
4.	Fecal Incontinence 01/01/1995 - "Functional results (bowel movements per 24 h, use of antidiarrheal drugs, seepage, and fecal incontinence) and quality of life were evaluated prospectively with a questionnaire and physical examination. " 02/01/2008 - "Patients presenting later with fecal incontinence may be managed successfully using antidiarrheal drugs and biofeedback. " 11/01/1995 - "Treatment of constipation often includes dietary measures and use of laxatives or prokinetic agents; fecal incontinence may respond to bulking or antidiarrheal agents. " 10/01/1989 - "Children in group 1 did less well than those in group 2 when the following parameters were compared: fecal incontinence (7/9 vs 0/5), perianal dermatitis (6/9 vs. 1/5), treatment with antidiarrheal agents (5/9 vs 0/5), missing school (4/9 vs 0/5) and diminished social activities (4/9 vs 0/5). " 01/01/1993 - "Therapies for bowel dysmotility syndromes (such as gastroparesis, diarrhea, and fecal incontinence) are described, including bulk agents, laxatives, prokinetic agents, and antidiarrheal drugs."
5.	Constipation 09/01/1998 - "The safest laxatives and antidiarrheals are those that are not absorbed and should be considered first-line therapy for conditions of constipation or loose stools. " 11/01/1995 - "Treatment of constipation often includes dietary measures and use of laxatives or prokinetic agents; fecal incontinence may respond to bulking or antidiarrheal agents. " 02/01/2011 - "dietary fiber and bulking agents for constipation, laxatives for constipation, antispasmodics for abdominal pain and discomfort, antidiarrheals for diarrhea. " 01/01/2001 - "Dietary modifications like fiber supplementation, antidiarrheal agents and antispasmodic drugs are the basis of the current treatment of IBS and depend on the predominant symptom (constipation, diarrhea or pain, respectively). " 04/01/2010 - "The mainstay of intervention is pharmacological treatment with antispasmodics and antidiarrheals for diarrhea, prokinetics and high-fiber diets for constipation, and supportive therapy with low-dose antidepressants to normalize gastrointestinal motility. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Antiemetics
3.	Parasympatholytics (Antispasmodics)
4.	Loperamide (Imodium)
5.	ORALIT (ORS)
6.	Morphine (MS Contin)
7.	Dinoprostone (PGE2)
8.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
9.	Naloxone (Narcan)
10.	Diphenoxylate

Related Therapies and Procedures

1.	Fluid Therapy (Oral Rehydration Therapy)
2.	Oral Administration
3.	Adjuvant Chemotherapy
4.	Tubal Sterilization (Tubal Ligation)
5.	Radiotherapy