Cohesins

Protein complex constituents that bind chromosomes from late G1 until the metaphase - anaphase transition. The cohesin complex regulates sister chromatid cohesion, HOMOLOGOUS RECOMBINATION and DNA looping.

Also Known As:

Networked: 422 relevant articles (5 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Musio, Antonio: 21 articles (03/2022 - 03/2007)
2.	Krantz, Ian D: 20 articles (01/2022 - 03/2007)
3.	Shirahige, Katsuhiko: 17 articles (06/2021 - 02/2008)
4.	Deardorff, Matthew A: 13 articles (01/2022 - 03/2007)
5.	Horsfield, Julia A: 13 articles (06/2021 - 12/2011)
6.	Losada, Ana: 13 articles (01/2021 - 12/2010)
7.	Dorsett, Dale: 11 articles (01/2022 - 10/2004)
8.	Gerton, Jennifer L: 10 articles (01/2019 - 01/2014)
9.	Mannini, Linda: 10 articles (12/2015 - 02/2009)
10.	Kline, Antonie D: 9 articles (01/2022 - 03/2007)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2013 - "STAG2, a subunit of cohesin, was significantly and commonly mutated or lost in UBC, mainly in tumors of low stage or grade, and its loss was associated with improved outcome. " 01/01/2021 - "This study provides a functional comparison of cohesin variants found in cancer within an isogenic system, revealing the relative roles of various cohesin perturbations on gene expression and maintenance of cellular identity." 11/01/2019 - "These studies identify a critical role for STAG2 in replication fork procession and elucidate a potential therapeutic strategy for cohesin-mutant cancers." 01/01/2019 - "Genetic alterations comprising any of the 11 cohesin-associated genes possibly occur in up to 26% of patients included in The Cancer Genome Atlas (TCGA) studies. " 01/01/2016 - "Recent studies have demonstrated that genes encoding cohesin subunits are somatically mutated in a wide range of human cancers. "
2.	Congenital Abnormalities (Deformity) 01/01/2019 - "Modest deficits in cohesin function that do not alter chromosome segregation cause significant birth defects. " 01/01/2018 - "These mechanistic insights provide new clues to understand the roles played by multiple cohesin complexes, especially in human infertility and birth defects." 10/01/2016 - "The clinical relevance of cohesin in DNA repair, tumorigenesis, and severe birth defects continues to fuel efforts in understanding cohesin structure, regulation, and enzymology. " 06/10/2010 - "We reasoned that as both cancer and birth defects share disrupted stem cell differentiation, the data suggest an APRIN/Pds5B cohesin function in stem cells. " 01/01/2016 - "Studies of these mouse and zebrafish CdLS models have helped clarify how deficiency for NIPBL, a protein that associates with cohesin and other transcriptional regulators in the nucleus, affects processes important to the emergence of the structural and physiological birth defects observed in CdLS: NIPBL exerts chromosome position-specific effects on gene expression; it influences long-range interactions between different regulatory elements of genes; and it regulates combinatorial and synergistic actions of genes in developing tissues. "
3.	Rupture 10/07/2016 - "A recent experimental study by Jobst et al. of stretching of a wild-type (WT) cohesin-dockerin complex has identified two kinds of the force-displacement patterns, with a single or double-peaked final rupture, which are termed "short" and "long" here. " 12/11/2012 - "The observed cohesin-dockerin rupture forces (>120 pN) are among the highest reported for a receptor-ligand system to date. " 12/11/2012 - "A cohesin amino acid mutation (D39A) that eliminated hydrogen bonding with the dockerin's critically conserved serine residues reduced the observed rupture forces. "
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2023 - "In primary human acute myeloid leukemia, mutations in cohesin are highly correlated with distinct patterns of alternative splicing. " 01/01/2023 - "Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome." 01/01/2022 - "Last, patient-derived acute myeloid leukemia cells harboring cohesin mutations exhibit a reduced response to GCs, suggesting that the GR-NIPBL-cohesin interaction is defective in these patients, resulting in poor response to GC treatment." 10/01/2021 - "Integrated genomic-metabolic classification of acute myeloid leukemia defines a subgroup with NPM1 and cohesin/DNA damage mutations." 01/01/2021 - "Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance."
5.	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/01/2020 - "Mutations in members of the cohesin complex are known early drivers of myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), with STAG2 the most frequently mutated complex member. " 12/01/2016 - "Lack of splice factor and cohesin complex mutations in pediatric myelodysplastic syndrome." 01/01/2021 - "Co-occurrence of cohesin complex and Ras signaling mutations during progression from myelodysplastic syndromes to secondary acute myeloid leukemia." 01/01/2018 - "Recurrent loss of function mutations within genes of the cohesin complex have been identified in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). " 09/11/2014 - "Somatic cohesin mutations have been reported in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Transcription Factors (Transcription Factor)
3.	Poly(ADP-ribose) Polymerase Inhibitors
4.	Histones (Histone)
5.	Serine (L-Serine)
6.	Amino Acids
7.	Chromatin
8.	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)
9.	HLA-B27 Antigen (HLA B27 Antigen)
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Transplantation