Lupanes

Pentacyclic triterpenes with isopropyl and its derivatives at the C19 position. It is initially biosynthesized by cyclization of oxidosqualene to lupeol.

Also Known As:

Lupane Type Pentacyclic Triterpenoids; Lupane Type Triterpenes; Lupane Type Triterpenoids; Triterpenoids, Lupane-Type; Lupane Derivatives; Lupane Triterpenes; Lupane Triterpenoids; Lupane-Type Pentacyclic Triterpenoids; Lupane-Type Triterpenes; Lupane-Type Triterpenoids

Networked: 28 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hata, Keishi: 4 articles (07/2008 - 05/2002)
2.	Hori, Kazuyuki: 4 articles (07/2008 - 05/2002)
3.	Tokuda, Harukuni: 3 articles (07/2009 - 03/2002)
4.	Castro, María Julia: 2 articles (12/2019 - 07/2019)
5.	Choi, Jae Sue: 2 articles (12/2019 - 12/2017)
6.	Faraoni, María Belén: 2 articles (12/2019 - 07/2019)
7.	Jung, Hyun Ah: 2 articles (12/2019 - 12/2017)
8.	Murray, Ana Paula: 2 articles (12/2019 - 07/2019)
9.	Seong, Su Hui: 2 articles (12/2019 - 12/2017)
10.	Holy, Jon: 2 articles (11/2014 - 08/2010)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 08/15/2010 - "In this study, we tested the ability of a number of dimethylaminopyridine (DMAP) derivatives of lupane triterpenoids to target mitochochondria in two human melanoma cell lines and an untransformed normal fibroblast line. " 07/01/2008 - "We evaluated the effects of various lupane triterpenes on B16 2F2 mouse melanoma cell differentiation and proliferation. " 11/01/2006 - "Lupane triterpenes were found to promote melanogenesis, a hallmark of B16 2F2 mouse melanoma cell differentiation. " 11/01/2006 - "Differentiation-inducing activity of lupane triterpenes on a mouse melanoma cell line." 11/01/2006 - "Studies of the structure-activity relationships demonstrated that the keto function at C-3 of the lupane skeleton played important roles in the melanogenic activities of lupane triterpenes on melanoma cells. "
2.	Human Influenza (Influenza) 10/20/2003 - "It was found that simple modifications of the parent structure of lupane triterpenes produced highly effective agents against influenza A and herpes simplex type 1 viruses." 03/01/2010 - "This study to identify anti-influenza components of the bark of Alnus japonica resulted in the isolation of four lupane-type triterpenes (1-4) and one steroid (5). "
3.	Neoplasms (Cancer) 01/01/2016 - "Lupane-type triterpenes and their anti-cancer activities against most common malignant tumors: A review." 09/15/2010 - "A class of novel aza-lupane triterpenoids were designed, synthesized, and evaluated for antitumor activity against a panel of cancer cell lines of different histogenic origin and for ability to induce apoptosis. " 07/01/2008 - "These results suggest that the carbonyl group at C-20 of lupane triterpenes played important roles in their apoptosis-inducing activity against cancer cells." 07/01/2008 - "Lupane triterpenes with a carbonyl group at C-20 induce cancer cell apoptosis." 12/01/2004 - "Potential anti-tumor promoting activity of lupane-type triterpenoids from the stem bark of Glochidion zeylanicum and Phyllanthus flexuosus."
4.	Leukemia 07/01/2008 - "Cytotoxic profiles of these lupane triterpenes against human cancer cells demonstrated that compounds 4-6 showed inhibitory effects on the proliferations of leukemia and lung cancer cells, to a greater extent than other cancer and normal fibroblast cells. " 06/05/2003 - "Lupane triterpenes with a carbonyl group at C-17 (7-11) showed inhibitory effects on leukemia, melanoma and neuroblastoma cell growth. "
5.	Inflammation (Inflammations) 04/01/1995 - "We have found that several lupane-type triterpenes, including lupeol, its acetate, betulin and betulinic acid, inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation, and that betulinic acid inhibits tumor promotion in two-stage carcinogenesis in mice. " 10/01/1996 - "Ten dihydroxy- and trihydroxy triterpenes, viz., four taraxastanes: faradiol, heliantriol B0, heliantriol C and arnidiol; two lupanes: calenduladiol and heliantriol B2; two oleananes: maniladiol and longispinogenin; and two ursanes: brein and uvaol, isolated from the nonsaponifiable lipids of the flower extracts of Compositae plants were evaluated with respect to their anti-inflammatory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. "

Related Drugs and Biologics

1.	oleanane
2.	Steroids
3.	lupane
4.	melanogen
5.	ursane
6.	Betulinic Acid
7.	lupeol
8.	Phytochemicals
9.	Triterpenes
10.	Lipids

Related Therapies and Procedures

1.	Therapeutics