Iron Deficiencies

Deficient amounts of iron in the body as a result of blood loss, diets deficient in iron, or an iron uptake or storage disorder.

Also Known As:

Deficiencies, Iron; Deficiencies, Latent Iron; Deficiency, Iron; Deficiency, Latent Iron; Hypoferritinemias; Iron Deficiencies, Latent; Iron Deficiency, Latent; Latent Iron Deficiencies; Sideropenias; Hypoferritinemia; Iron Deficiency; Latent Iron Deficiency; Sideropenia

Networked: 10424 relevant articles (476 outcomes, 1314 trials/studies)

Relationship Network

Disease Context: Research Results

Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Iron Metabolism Disorders: 78
    - Iron Deficiencies: 10424
      - Iron-Deficiency Anemia: 4137

Related Diseases

1.	Anemia
2.	Heart Failure
3.	Iron-Deficiency Anemia (Anemia, Iron Deficiency)
4.	Chronic Renal Insufficiency
5.	Malaria

Experts

1.	Georgieff, Michael K: 71 articles (03/2022 - 09/2002)
2.	Zimmermann, Michael B: 46 articles (01/2022 - 04/2002)
3.	Ponikowski, Piotr: 45 articles (01/2022 - 01/2008)
4.	Anker, Stefan D: 41 articles (01/2022 - 02/2004)
5.	Lozoff, Betsy: 35 articles (06/2022 - 02/2003)
6.	Macdougall, Iain C: 33 articles (02/2022 - 03/2002)
7.	Puig, Sergi: 32 articles (01/2022 - 03/2007)
8.	Hurrell, Richard F: 32 articles (01/2021 - 04/2002)
9.	Nishizawa, Naoko K: 29 articles (01/2022 - 12/2003)
10.	Jankowska, Ewa A: 27 articles (01/2022 - 08/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Iron Deficiencies:

1.	IronIBA 05/23/2018 - "Altogether, this study indicates that these synthetic FG-iron nanocomposites might be developed as novel iron supplements for iron deficiency, in which FG-FeCl3 is considered as the best option." 01/30/2023 - "Oral iron supplementation is the most widely used and cost-effective treatment for iron deficiency and IDA. " 10/31/2022 - "Our results indicate that the combined introduction of OsHRZ knockdown and OsIRT1 promoter-Refre1/372 is highly effective in further improving the iron deficiency tolerance without compromising the iron accumulation of the OsHRZ knockdown effects." 01/01/2022 - "For the detection of iron depletion (IDA or ACD/IDA) in anemic RA patients, sTfR is superior to SP of iron deficiency only in highly inflammatory states." 01/01/2022 - "Nevertheless, in the meantime, focusing on iron supplementation in high-risk mothers with emphasis on compliance, seems to be the best option, in view of the high prevalence of iron deficiency found in this review."
2.	Ferritins (Ferritin)IBA 06/01/2017 - "Bone marrow aspiration is the gold standard test for iron deficiency but requires an invasive procedure; therefore, serum ferritin is the most clinically useful test. " 03/01/2002 - "Therefore, assessment of the HRBC proportion is superior to decreased ferritin and decreased TSAT measurements for the diagnosis of iron deficiencies among renal transplant recipients." 01/01/2000 - "One month after TDI, Hb was 8.0 + 1.0 g/dL and serum ferritin was 362 ng/mL. We feel that TDI is a safe and effective method of correcting iron deficiency in predialysis patients." 10/01/2020 - "Serum ferritin improved (131.0 vs. 267.5 μg/L; P < 0.001), and fewer patients had iron deficiency (56.7% vs. 26.8%; P = 0.002) at last visit compared to the first. " 01/01/2017 - "We assessed risk groups for iron deficiency and the feasibility and efficacy of ferritin testing in a large blood center. "
3.	ferric carboxymaltoseIBA 07/28/2023 - "Administration of ferric carboxymaltose has proved beneficial in studies on iron deficiency correction in cardiological and cardio-surgical patients. " 01/01/2014 - "Overall, as part of this non-interventional study for everyday routine in a gynaecological practice, a rapid improvement in symptoms accompanied by the rectification of iron deficiency and anaemia was shown with low occurrences of mild undesirable events, and therefore the data obtained from controlled clinical studies on the effectiveness and tolerance of intravenous ferric carboxymaltose could be confirmed. " 01/01/2022 - "Clinical studies have shown that iron carboxymaltose (ICM) is an appropriate, effective, and well-tolerated treatment option for clinical situations associated with iron deficiency (ID). " 09/08/2017 - "Intravenous ferric carboxymaltose was safe and effective in pregnent women with iron deficiency anaemia." 03/25/2014 - "Our prospective data is consistent with existing observational reports of the safe and effective use of ferric carboxymaltose in the treatment of iron deficiency anaemia in pregnancy."
4.	Hemoglobins (Hemoglobin)IBA 05/01/2022 - "Benefits for term neonates include higher hemoglobin levels, less iron deficiency in infancy, improved myelination out to 12 months, and better motor and social development at 4 years of age especially in boys. " 07/01/1996 - "To determine the incidence of iron deficiency among healthy women of child-bearing age, study the predictive value of blood hemoglobin level for this condition and assess the efficacy of a community screening program. " 10/01/2017 - "Reticulocyte Hemoglobin Content (CHr): The Gold Standard for Diagnosing Iron Deficiency." 10/18/2023 - "Reticulocyte hemoglobin equivalent as a marker to assess iron deficiency: A large pediatric tertiary care hospital study." 01/01/2021 - "The aim of this study is to prove the usefulness of reticulocyte hemoglobin equivalent (Ret-He) as a reliable and effective tool in diagnosis of iron deficiency in hypothyroid patients. "
5.	Erythropoietin FDA Link 02/01/1994 - "Iron deficiency severely limits the efficacy of recombinant human erythropoietin (EPO). " 09/01/1998 - "Some studies have shown a decrease in recombinant human erythropoietin (rHuEPO) dosage with correction of iron deficiency. " 03/01/1998 - "Erythropoietin and iron deficiency in the study group were not observed. " 12/01/2022 - "The insufficient erythropoietin (EPO) production by the kidneys and iron deficiency are the main causes. " 11/01/2022 - "Inadequate erythropoietin production and absolute or functional iron deficiency are the major causes. "
6.	ferrous sulfate FDA Link 01/01/2019 - "Treatment with low-dose ferrous sulfate is well-tolerated and effective in correcting iron deficiency in children. " 01/01/2022 - "IHAT has proved a safe and effective alternative to oral ferrous sulfate in mice, and it has potential for treating iron deficiency in human pregnancy." 01/01/2019 - "To evaluate the efficacy of low dose ferrous sulfate for the treatment of iron deficiency and if the probiotic Lactobacillus plantarum 299v (LP299v) enhances treatment. " 01/01/2019 - "This randomized, double-blinded, controlled trial of the treatment of iron deficiency in children compared the use of low-dose ferrous sulfate (1-3 mg/kg/day), with or without probiotic (LP299v). " 03/01/2012 - "Efficacy and tolerability of a prolonged release ferrous sulphate formulation in iron deficiency anaemia: a non-inferiority controlled trial."
7.	Transferrin (beta 2 Transferrin)IBA 01/01/1994 - "Efficacy of transferrin determination in human sera in the diagnosis of iron deficiency." 10/06/2011 - "Four variants in transferrin and HFE genes as potential markers of iron deficiency anaemia risk: an association study in menstruating women." 04/01/1991 - "Transferrin saturation studies in male adults showing high prevalence of iron deficiency." 12/01/1989 - "This study, designed to assess the clinical use of transferrin and transferrin saturation in the diagnosis of iron deficiency anaemia in the elderly, illustrates how these tests have a lower specificity in this age group, limiting their clinical use. " 05/18/2023 - "26% of individuals demonstrated transferrin saturation TfS < 20%, which clearly indicates age-related iron deficiency. "
8.	HepcidinsIBA 04/09/2014 - "Chronic elevations in hepcidin levels may help to explain the high incidence of iron deficiency in athletes." 07/01/2009 - "However, this study showed that determination of hepcidin concentrations together with M/F improved the identification of iron deficiency in pretransplant patients by 21.6%." 11/01/2010 - "Hfe Tg mice also exhibited increased hepatic BMP6-SMAD target gene expression compared with WT mice, whereas anti-BMP6 antibody administration to Hfe Tg mice improved the hepcidin excess and iron deficiency. " 11/01/2021 - "In the present study, we investigated the diagnostic features of hepcidin concentration as an iron deficiency assay during the second trimester of pregnancy. " 04/01/2021 - "The study found a significant correlation between serum hepcidin and iron deficiency-related parameters with adjustment for study groups (p<.01). "
9.	Vitamin A (Retinol)FDA LinkGeneric 07/01/2022 - "After 6 weeks rats showed no significant effects of variations in vitamin A on the expression of Hamp relative to the control group (FesvAi: 1.37-fold; FesvAd: 1.22-fold); however, iron deficiency showed significant reduction on it relative to the control group (FeivAs: 71.4-fold, P = 0.0004; FeivAi: 16.1-fold, P = 0.0008). " 01/01/2011 - "The nutritional education intervention produced a significant reduction in iron deficiency prevalence (25 to 14%), and showed no effect on vitamin A and folates deficiencies. " 05/01/2007 - "Iron deficiency may limit the efficacy of vitamin A to normalize dark adaptation in pregnant Nepali women. " 10/01/2019 - "The present study introduced a food basket intervention and assessed the effectiveness of the food baskets with respect to addressing anaemia, vitamin A and iron deficiencies among pregnant Maasai women within the Ngorongoro Conservation Area. " 09/01/2009 - "To study the effect of iron deficiency on vitamin A (VA) metabolism in rats. "
10.	Transferrin Receptors (Transferrin Receptor)IBA 08/01/1999 - "A prospective hospital-based study was conducted to evaluate the efficacy of serum transferrin receptors in the detection of iron deficiency in pregnant women. " 02/01/2020 - "The gold standard used for diagnosing iron deficiency was soluble transferrin receptor (sTfR), with a cut-off of >52 nmol/L. " 12/01/2004 - "We also measured serum transferrin receptor levels to use as the gold standard laboratory test for iron deficiency against which we compared the Ret-Y. " 10/01/2020 - "The present study ascertains the prevalence of iron deficiency and its related factors in adolescents, using the serum transferrin receptor and the reticulocyte haemoglobin content, in order to avoid this confusing effect of classical parameters. " 01/01/2012 - "Prevalence of Anaemia and Evaluation of Transferrin Receptor (sTfR) in the Diagnosis of Iron Deficiency in the Hospitalized Elderly Patients: Anaemia Clinical Studies in Chile."

Therapies and Procedures

1.	Therapeutics 01/01/2002 - "However, the detection of iron deficiency in COMBI patients is very useful for the initiation of replacement therapy. " 08/01/2021 - "Furthermore, the treatment of patient comorbidities (e.g., iron deficiency) has shown to improve functional capacity and to reduce hospitalization rates, when added to standard therapy. " 11/01/2005 - "pylori therapy on iron deficiency, we conducted a household-randomized, open-label treatment trial involving children aged 7-11 years in 10 villages in western Alaska. " 03/01/2004 - "In the present study, we clinically investigated the relationship between taste disturbances and serum iron deficiency as well as the results of pharmacological therapy. " 09/01/1992 - "These infants were among the most anaemic at entry into the study and 2 of them were unable to complete rHuEPO therapy, while the third developed iron deficiency anaemia. "
2.	Renal Dialysis (Hemodialysis) 06/01/2006 - "This multicenter observational study evaluated stable hemodialysis patients without iron deficiency who had a stable SC epoetin dosage and Hb level of 10 g/dL or greater (> or =100 g/L) at the time of study enrollment. " 01/01/2006 - "Despite the high prevalence of iron deficiency in hemodialysis patients, no studies have been performed in this population. " 12/01/2001 - "A randomized trial of iron deficiency testing strategies in hemodialysis patients." 12/01/1990 - "This study demonstrated that the use of RDW in the detection of iron deficiency in chronic hemodialysis patients was superior to mean corpuscular volume but still limited." 04/01/1988 - "This study has confirmed the usefulness of the RDW as a screening test for iron deficiency in chronic hemodialysis patients. "
3.	Blood Transfusion (Blood Transfusions) 01/01/2020 - "Through a series of three QI cycles, we have treated iron deficiency, improved preoperative haemoglobin (Hb) and reduced the rate of postoperative blood transfusion. " 12/01/2008 - "This study was conducted to evaluate the frequency of iron deficiency and relevant factors in frequent and first time female blood donors at Casablanca blood transfusion centre, Morocco. " 08/01/2005 - "This study was conducted to evaluate the prevalence of iron deficiency and its related factors in blood donors at Yazd blood transfusion centre, Iran. " 01/01/2022 - "Preoperative Iron Deficiency Is Associated With Increased Blood Transfusion in Infants Undergoing Cardiac Surgery." 11/01/2021 - "Iron deficiency anaemia in orthopaedic surgery is common and there is increased risk of blood transfusion and associated adverse reactions. "
4.	Patient Readmission 01/01/2023 - "Iron deficiency screening improved over time but is still limitedly implemented, despite being highly prevalent and incident, and independently associated with CV death or HF rehospitalizations regardless of EF. " 08/05/2022 - "Given the negative impact of iron deficiency on HF progression, the frequency and financial implications of rehospitalizations due to decompensation episodes, and the efficacy of this supplementation, screening for this frequent comorbidity should be part of routine testing in all HF patients. " 08/05/2022 - "The correction of iron deficiency in HF patients is associated with improved functional capacity, quality of life, and rehospitalization rates. " 05/01/2013 - "Current iron deficiency treatment strategies are mismanaged and CARMES-1 demonstrated that they appear to be insufficient at improving patient outcome in terms of rehospitalization rate reduction, generating high costs, which could be avoided through an optimized treatment strategy. " 05/01/2013 - "However, current iron deficiency treatment strategies were not significantly associated with reduced risk of rehospitalization, but with a significantly reduced mortality rate after a 6-month follow-up (study secondary end points: 11.7 vs 51.7%; p < 0.0001). "
5.	Drug Therapy (Chemotherapy) 11/01/2002 - "This failure may be due to factors related to the underlying disease, the chemotherapy given or functional iron deficiency. " 01/01/2017 - "The present study considered a cohort of 64 patients with chemotherapy-related anemia (Hb >8 g/dL <10 g/dL) and no absolute or functional iron deficiency, scheduled to receive chemotherapy and darbepoetin. " 04/01/2020 - "Iron deficiency during first-line chemotherapy in metastatic cancers: a prospective epidemiological study." 12/18/2018 - "Differential diagnosis of anaemia and thrombocytopaenia in patients with cancer include bone morrow involvement by cancer cells, iron-deficiency anaemia, microangiopathies and chemotherapy suppression of haematopoiesis. " 08/01/2014 - "Patients with cancer frequently experience chemotherapy-induced anaemia (CIA) and iron deficiency. "