Iron-Deficiency Anemia (Anemia, Iron Deficiency)

Anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. The erythrocytes are hypochromic and microcytic and the iron binding capacity is increased.

Also Known As:

Anemia, Iron Deficiency; Anemia, Iron-Deficiency; Anemias, Iron-Deficiency; Iron-Deficiency Anemias; Anemias, Iron Deficiency; Iron Deficiency Anemia; Iron Deficiency Anemias

Networked: 4137 relevant articles (235 outcomes, 584 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Anemia
2.	Iron Deficiencies
3.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
4.	Heart Failure
5.	Hemorrhage

Experts

1.	Lozoff, Betsy: 21 articles (01/2019 - 02/2003)
2.	Auerbach, Michael: 19 articles (01/2022 - 01/2010)
3.	Hurrell, Richard F: 17 articles (04/2022 - 07/2002)
4.	Zimmermann, Michael B: 17 articles (01/2022 - 07/2002)
5.	Strauss, William E: 14 articles (01/2021 - 04/2014)
6.	Bhandari, Sunil: 12 articles (01/2021 - 01/2011)
7.	Thomsen, Lars L: 11 articles (01/2022 - 09/2011)
8.	Georgieff, Michael K: 10 articles (01/2022 - 09/2002)
9.	Pollock, Richard F: 10 articles (01/2022 - 01/2017)
10.	Pergola, Pablo E: 10 articles (12/2021 - 05/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Iron-Deficiency Anemia:

1.	IronIBA 01/01/2005 - "The prevalence of iron deficiency anemia (IDA) during the first year of life has been dramatically reduced in developed countries, mainly due to the increase in breastfeeding and the use of iron-fortified feeding formulae. " 03/01/2011 - "A previous study among schoolchildren supplemented with iron-fortified rice showed a significant reduction in the rate of iron-deficiency anemia from 100% to 33%. " 01/01/2020 - "Whether this dosing schedule is also beneficial in women with iron-deficiency anemia (IDA) given high-dose iron supplements is uncertain. " 09/01/2007 - "Because biscuits are a popular snack item and are consumed frequently by the younger population, fortification of biscuits with iron can be beneficial in preventing iron-deficiency anemia, which is widely prevalent in developing countries. " 10/01/2004 - "Iron deficiency anemia (IDA) is a significant public health challenge in resource-poor settings, despite strong evidence for efficacy of iron supplementation. "
2.	Hemoglobins (Hemoglobin)IBA 11/23/2023 - "This study showed that including pharmacists in the management of pregnant patients with iron-deficiency anemia significantly improved patient hemoglobin levels at delivery." 03/01/2002 - "All children showed recovery from iron-deficiency anemia, with statistically similar improvement in hemoglobin levels. " 01/01/2005 - "New parameters correlated with the hemoglobin content in reticulocytes (RET-Y) and in red blood cells (RBC-Y) have been suggested as helpful in diagnosing iron deficiency anemia. " 01/01/2023 - "Similarly, two studies found that not correcting hemoglobin for altitude improved the receiver operating characteristic (ROC) curves for the diagnosis of iron deficiency anemia. " 10/17/2014 - "Post administration of FCM, correction of iron deficiency anemia was observed with improved mean hemoglobin levels from 9.5 g/dL at baseline to 11.9 g/dL within 5-12 weeks. "
3.	ferric carboxymaltoseIBA 10/07/2021 - "Ferric carboxymaltose (FCM) is highly effective in supplementing iron-deficiency anemia and frequently used. " 01/01/2018 - "Ferric carboxymaltose was found to be an effective and well tolerated treatment for iron deficiency anemia in patients with IBD. " 08/01/2023 - "The purpose of this study was to evaluate the safety and efficacy of ferric carboxymaltose (FCM) in reducing the need for perioperative transfusion in iron deficiency anemia patients scheduled for PD. " 01/01/2019 - "Safety and efficacy of intravenous ferric carboxymaltose in Japanese patients with iron-deficiency anemia caused by digestive diseases: an open-label, single-arm study." 01/01/2012 - "Safety and Efficacy of Intravenous Ferric Carboxymaltose (750 mg) in the Treatment of Iron Deficiency Anemia: Two Randomized, Controlled Trials."
4.	Saccharated Ferric Oxide (Venofer)FDA Link 06/01/2012 - "Intravenous Iron sucrose is a safe and effective treatment for the rapid reversal of iron deficiency anemia, in obstetric and gynecological settings." 01/01/2021 - "FERWON-NEPHRO was a randomized, open-label, multicenter clinical trial evaluating the safety and efficacy of a single infusion of FDI 1,000 mg versus up to 5 doses of iron sucrose (IS) 200 mg (recommended cumulative dose, 1,000 mg) over 8 weeks in patients with NDD-CKD and iron deficiency anemia. " 04/01/2014 - "Two 750-mg infusions of FCM are a safe and effective alternative to multiple lower dose iron sucrose infusions in NDD-CKD patients with iron-deficiency anemia." 03/01/2007 - "There is no apparent difference in the safety and efficacy of iron sucrose between elder and younger adults in the treatment of iron-deficiency anemia in HDD patients with CKD." 02/01/2016 - "Intravenous iron sucrose for children with iron deficiency anemia: a single institution study."
5.	Ferritins (Ferritin)IBA 01/01/1984 - "Comparative investigations of the therapeutic efficacy of ITF282 and ferritin made on uncomplicated iron deficiency anemia show that the drugs, p.o. " 06/01/2022 - "In the study group, the most frequently performed test type was serum ferritin level (82.3%), followed by complete blood count (81%), both of which revealed that 6.2% of the patients had iron deficiency anemia. " 08/01/2021 - "A Study to Assess the Levels of Salivary Ferritin in Iron Deficiency Anemia Subjects and Healthy Subjects." 07/01/2017 - "This study was performed to determine the diagnostic properties of serum ferritin in the diagnosis of iron deficiency anemia in older subjects. " 01/01/2017 - "Of the patients who remained in the study until the 120-month follow-up, 37.5 and 45.0% were diagnosed with iron-deficiency anemia, defined as ferritin <15 μg/L and ferritin <30 μg/L, respectively. "
6.	Ferrosoferric Oxide (Magnetite)FDA Link 02/01/2023 - "Ferumoxytol: an emerging therapeutic for iron deficiency anemia." 01/01/2019 - "The Efficacy of Ferumoxytol for Iron Deficiency Anemia: A Meta-Analysis of Randomized Controlled Trials." 01/01/2019 - "We search for randomized controlled trials (RCTs) assessing the effect of ferumoxytol on iron deficiency anemia on PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases. " 05/01/2023 - "Intravenous ferumoxytol infusions are an effective treatment option for iron deficiency anemia. " 05/18/2022 - "Ferumoxytol (FMX) is an iron oxide nanoparticle that is FDA approved for the treatment of iron deficiency anemia. "
7.	Erythropoietin FDA Link 08/01/2013 - "This response impairs erythropoietin-driven erythropoiesis and underlies erythropoietic repression in iron deficiency anemia. " 12/01/2008 - "Iron deficiency anemia is common in people with CKD and its importance in supporting erythropoiesis is unquestioned, especially in those patients treated with erythropoietin. " 01/01/2001 - "Erythropoietin in the treatment of iron deficiency anemia during pregnancy." 10/01/1997 - "Serum erythropoietin (EPO) levels were determined in 30 children with iron deficiency anemia. " 10/01/1997 - "Serum erythropoietin in children with iron deficiency anemia."
8.	Dextrans (Dextran)FDA Link 08/15/1973 - "[Editorial: Is intravenous dextran a recommended treatment for iron-deficiency anemia?]." 03/01/2001 - "A single dose of 200 mg/ml iron-dextran is effective against iron deficiency anemia. " 08/01/2010 - "Total parenteral iron replacement with LMW iron dextran is an easy, safe, and effective alternative method for treating iron deficiency anemia in IBD. " 07/01/2008 - "We conclude that the total parenteral iron replacement with low molecular weight iron dextran is an effective and safe method for the treatment of iron deficiency anemia in a selected group of pregnant women." 01/01/2021 - "A retrospective study of the safety and efficacy of low molecular weight iron dextran for children with iron deficiency anemia."
9.	teferrolIBA 02/01/2019 - "Noripurum EV® in pediatric patients with IBD and iron deficiency anemia was effective and safe, making it an appropriate option for the clinical management of these patients." 01/02/2007 - "The efficacy of iron polymaltose complex (IPC) in the treatment of iron deficiency anemia (IDA) during pregnancy has not been well established, and the evidence is inconclusive. " 01/01/2021 - "Effectiveness of iron polymaltose complex in treatment and prevention of iron deficiency anemia in children: a systematic review and meta-analysis." 01/01/2016 - "Iron Polymaltose Complex in the Treatment of Iron Deficiency Anemia in Pregnancy." 08/01/2012 - "The originator iron polymaltose complex (Maltofer®, IPC, Vifor International, St. Gallen, Switzerland) has been used for over 30 years to treat iron deficiency anemia. "
10.	ferrous sulfate FDA Link 01/01/2021 - "Primary objective of this study was to retrospectively evaluate the efficacy of FCM compared with oral ferrous sulfate for the treatment of iron-deficiency anemia in a cohort of NDD-CKD patients, considering also the treatment costs. " 11/01/1996 - "prospective, open, controlled study in which pregnant women with iron deficiency anemia were sequentially selected from the antenatal clinic and assigned either to ISC (study group) or to ferrous sulfate (control group). " 01/01/2023 - "Herein we report a case of a 79-year-old woman with iron-deficiency anemia taking oral ferrous sulfate with multiple congestive and eroded polypoid lesions. " 01/01/2021 - "Routine intravenous FCM treatment in an outpatient clinic of NDD-CKD patients results in better correction of iron-deficiency anemia when compared to ferrous sulfate. " 05/01/2019 - "Comparative liver function assessment of natural and available drug (Ferrous sulfate) for iron-deficiency anemia in rat model."

Therapies and Procedures

1.	Therapeutics 06/01/2015 - "Given that intravenous therapies have been introduced in the last decade, a systematic review performed in PubMed, EMBASE, the Cochrane Library, and the websites of WHO, FDA, and EMA covered prospective trials investigating the management of iron-deficiency anemia in IBD published since 2004. " 07/01/2005 - "Effect of anti-Helicobacter pylori therapy on outcome of iron-deficiency anemia: a randomized, controlled study." 01/01/2004 - "In the present study, the effects of the eradication therapy on iron deficiency anemia were investigated. " 04/01/2022 - "Diagnosis and Therapy of Iron Deficiency Anemia During Pregnancy: Recommendation of the Austrian Society for Gynecology and Obstetrics (OEGGG)." 01/01/2020 - "We review the clinical experience with systemic liposomal drug delivery and parenteral therapy of iron deficiency anemia (IDA) with iron oxide nanoparticles. "
2.	Renal Dialysis (Hemodialysis) 11/01/2001 - "Our study featured ten hemodialysis patients with iron deficiency anemia. " 07/01/2022 - "Absolute iron deficiency anemia was higher in non dialysis (48.33%; n=29) while functional iron deficiency anemia was higher in hemodialysis (34.52%; n=29). " 12/01/2020 - "Iron-deficiency anemia is common in hemodialysis patients. " 09/15/2017 - "Objective Iron deficiency anemia (IDA) has become important with regard to mortality in hemodialysis (HD) patients. " 01/01/1997 - "Use of statistical classifiers as support tools for the diagnosis of iron-deficiency anemia in patients on chronic hemodialysis."
3.	Blood Transfusion (Blood Transfusions) 08/01/2018 - "Intravenous FCM can be an effective and safe alternative to blood transfusion also in selected cases of severe iron-deficiency anemia in children." 01/01/2016 - "This study aimed to estimate the extend of iron deficiency, anemia and iron deficiency anemia in volunteer blood donors (DS) in the National Blood Transfusion Center (CNTS) in Kinshasa, DRC. " 01/01/2022 - "The patient was diagnosed with iron deficiency anemia and hospitalized for blood transfusion 2 years before she visited our dental clinic. " 09/01/2020 - "Contemporary management of severe iron deficiency anemia (IDA) in this setting may be inadequate and expose patients to unnecessary blood transfusions. " 01/01/2019 - "The diagnostics and treatment of iron deficiency anemia can be carried out before patients undergo surgery as an alternative to blood transfusion and is an interdisciplinary task. "
4.	Aftercare (After-Treatment) 11/13/2020 - "The mean HbA1c before treatment were 6.1% ± 0.23% and 5.5% ± 0.24%, and the values after treatment were 5.1% ± 0.14% and 4.6% ± 0.2% in severe iron deficiency anemia subgroup and mild to moderate subgroup, respectively. " 10/01/2009 - "Linear growth in children with iron deficiency anemia before and after treatment." 10/01/1975 - "[Dynamics of microcyte in iron deficiency anemia before and after treatment (author's transl)]." 10/01/2014 - "We aimed to investigate the effects of iron deficiency (ID) or iron-deficiency anemia (IDA) on oxidative stress and renal tubular functions before and after treatment of children. " 07/16/2015 - "We aimed to investigate the effects of iron deficiency anemia (IDA) and vitamin B12 deficiency coexisting with IDA which is called as mixed anemia (MA) on hemorheological parameters, to compare them with each other and healthy controls, and to assess the changes in hemorheological parameters after treatment. "
5.	Gluten-Free Diet 01/01/2001 - "Efficacy of gluten-free diet alone on recovery from iron deficiency anemia in adult celiac patients." 12/01/2013 - "Iron deficiency anemia is the most common extra-intestinal sign of CD and usually resolves with adherence to a gluten-free diet. " 07/21/2006 - "Iron deficiency anemia was found in 63.2% of patients and this became normal after adoption of a gluten-free diet in all patients. " 01/01/2001 - "Prospective studies on the effect of gluten-free diet on recovery from iron deficiency anemia are lacking. " 01/01/2001 - "The aim of this study was to verify in adult patients with celiac disease the efficacy of and the time course of recovery from iron deficiency anemia by a gluten-free diet alone. "