Iron-Deficiency Anemia (Anemia, Iron Deficiency)

Anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. The erythrocytes are hypochromic and microcytic and the iron binding capacity is increased.

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Networked: 2520 relevant articles (116 outcomes, 340 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Anemia
2.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
3.	Chronic Disease (Chronic Diseases)
4.	Heart Failure
5.	Dysmenorrhea (Menstrual Pain)

Experts

1.	Lozoff, Betsy: 18 articles (08/2015 - 02/2003)
2.	Hurrell, Richard F: 14 articles (11/2014 - 07/2002)
3.	Camaschella, Clara: 11 articles (12/2015 - 05/2009)
4.	Zimmermann, Michael B: 10 articles (10/2012 - 07/2002)
5.	Lönnerdal, Bo: 9 articles (07/2012 - 10/2002)
6.	Breymann, Christian: 8 articles (10/2015 - 11/2002)
7.	Beaumont, Carole: 8 articles (11/2014 - 04/2002)
8.	Silvestri, Laura: 8 articles (11/2014 - 05/2009)
9.	Bregman, David B: 8 articles (04/2014 - 01/2012)
10.	Milman, Nils: 8 articles (03/2014 - 07/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Iron-Deficiency Anemia:

1.	IronIBA 01/01/2005 - "The prevalence of iron deficiency anemia (IDA) during the first year of life has been dramatically reduced in developed countries, mainly due to the increase in breastfeeding and the use of iron-fortified feeding formulae. " 03/01/2001 - "We concluded that the use of sweet rolls fortified with 2 mg of iron from the bis-glycinate chelate is highly effective for the control of iron deficiency and iron deficiency anemia in young children." 03/01/2011 - "A previous study among schoolchildren supplemented with iron-fortified rice showed a significant reduction in the rate of iron-deficiency anemia from 100% to 33%. " 09/01/2007 - "Because biscuits are a popular snack item and are consumed frequently by the younger population, fortification of biscuits with iron can be beneficial in preventing iron-deficiency anemia, which is widely prevalent in developing countries. " 10/01/2005 - "This suggests that high iron-demand reproductive functions helped to make iron-deficiency anemia a chronic condition in many women's lives irrespective of their status affiliation."
2.	saccharated ferric oxideFDA Link 06/01/2012 - "Intravenous Iron sucrose is a safe and effective treatment for the rapid reversal of iron deficiency anemia, in obstetric and gynecological settings." 04/01/2014 - "Two 750-mg infusions of FCM are a safe and effective alternative to multiple lower dose iron sucrose infusions in NDD-CKD patients with iron-deficiency anemia." 03/01/2007 - "There is no apparent difference in the safety and efficacy of iron sucrose between elder and younger adults in the treatment of iron-deficiency anemia in HDD patients with CKD." 06/01/2012 - "The present study was undertaken to assess the impact of intravenous iron sucrose (Feronia IV) in the treatment of iron deficiency anemia observed in gynecological and obstetrical practice. " 08/01/2004 - "The aim of the present study was to evaluate the safety and tolerability of intravenous high-dose iron sucrose therapy specifically in patients with iron deficiency anemia (IDA) due to gastrointestinal blood loss. "
3.	Hemoglobins (Hemoglobin)IBA 03/01/2002 - "All children showed recovery from iron-deficiency anemia, with statistically similar improvement in hemoglobin levels. " 01/01/2005 - "New parameters correlated with the hemoglobin content in reticulocytes (RET-Y) and in red blood cells (RBC-Y) have been suggested as helpful in diagnosing iron deficiency anemia. " 01/01/2014 - "Post administration of FCM, correction of iron deficiency anemia was observed with improved mean hemoglobin levels from 9.5 g/dL at baseline to 11.9 g/dL within 5-12 weeks. " 05/01/2013 - "The study group consisted of 77 patients with a documented preoperative hemoglobin level (Hb) consistent with iron-deficiency anemia and a follow-up level at least 3 months following surgery. " 01/01/2013 - "The present study evaluated alterations of primary hemostasis in children with iron deficiency anemia caused by low hemoglobin using the PFA-100 instrument. "
4.	ErythropoietinFDA Link 08/01/2013 - "This response impairs erythropoietin-driven erythropoiesis and underlies erythropoietic repression in iron deficiency anemia. " 12/01/2008 - "Iron deficiency anemia is common in people with CKD and its importance in supporting erythropoiesis is unquestioned, especially in those patients treated with erythropoietin. " 01/01/2001 - "Erythropoietin in the treatment of iron deficiency anemia during pregnancy." 10/01/1997 - "Serum erythropoietin (EPO) levels were determined in 30 children with iron deficiency anemia. " 10/01/1997 - "Serum erythropoietin in children with iron deficiency anemia."
5.	Dextrans (Dextran)FDA Link 08/15/1973 - "[Editorial: Is intravenous dextran a recommended treatment for iron-deficiency anemia?]." 03/01/2001 - "A single dose of 200 mg/ml iron-dextran is effective against iron deficiency anemia. " 08/01/2010 - "Total parenteral iron replacement with LMW iron dextran is an easy, safe, and effective alternative method for treating iron deficiency anemia in IBD. " 07/01/2008 - "We conclude that the total parenteral iron replacement with low molecular weight iron dextran is an effective and safe method for the treatment of iron deficiency anemia in a selected group of pregnant women." 03/01/2002 - "The objective of this study was to examine the incidence and prevalence of iron deficiency anemia in patients on long-term HPN (>6 months) and to investigate both the efficacy of and rate of adverse reactions to parenteral iron dextran therapy. "
6.	Ferritins (Ferritin)IBA 01/01/1984 - "Comparative investigations of the therapeutic efficacy of ITF282 and ferritin made on uncomplicated iron deficiency anemia show that the drugs, p.o. " 01/01/2012 - "The objective of the study was to determine the salivary Ferritin levels in children with iron deficiency anemia and its reliability as a predictive marker of the disease and whether these levels could give a new hypothetical insight on the oral epithelial changes seen in patients with iron deficiency anemia. " 11/01/2009 - "The aim of this study was to evaluate the periodontal status of patients with iron-deficiency anemia (IDA) and the correlation of changes in serum and gingival crevicular fluid (GCF) ferritin levels after periodontal therapy. " 09/01/1998 - "The aim of this study was to establish whether extremely low serum ferritin values in female athletes were associated with indications of iron deficiency anemia and whether serum ferritin values were influenced by the type of training or participants' body size. " 01/01/1993 - "Performed in conjunction with serum ferritin measurements, the serum receptor will be useful in establishing the true prevalence of iron deficiency anemia in population studies."
7.	ferric carboxymaltoseIBA 01/01/2012 - "Safety and Efficacy of Intravenous Ferric Carboxymaltose (750 mg) in the Treatment of Iron Deficiency Anemia: Two Randomized, Controlled Trials." 09/01/2013 - "Comparative review of the safety and efficacy of ferric carboxymaltose versus standard medical care for the treatment of iron deficiency anemia in bariatric and gastric surgery patients." 04/01/2014 - "Ferric carboxymaltose in patients with iron-deficiency anemia and impaired renal function: the REPAIR-IDA trial." 02/01/2014 - "A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia." 01/01/2010 - "Efficacy and safety of ferric carboxymaltose in correcting iron-deficiency anemia: a review of randomized controlled trials across different indications."
8.	Transferrin Receptors (Transferrin Receptor)IBA 01/15/2007 - "At all stages of differentiation in our study, transferrin receptor expression in bone marrow erythroid cells in Fech(m1Pas) was normal in mutant mice but not in patients with iron-deficiency anemia. " 12/01/2005 - "In this study of 50 breath-holders, while iron-deficiency anemia was detected in 28 (56%) of patients with routine tests, serum transferrin receptor levels were found increased in all patients. " 01/01/2015 - "An unusual case of iron deficiency anemia is associated with extremely low level of transferrin receptor." 01/01/2015 - "The usefulness of soluble transferrin receptor in the diagnosis and treatment of iron deficiency anemia in children." 04/01/2011 - "It is concluded that the assessment of serum transferrin receptor levels is a useful method for the diagnosis of iron deficiency anemia in patients. "
9.	ferrous sulfateFDA Link 06/01/2005 - "[Efficacy of complex Hongyibuxue oral solution and ferrous sulfate for iron deficiency anemia]." 11/01/1996 - "prospective, open, controlled study in which pregnant women with iron deficiency anemia were sequentially selected from the antenatal clinic and assigned either to ISC (study group) or to ferrous sulfate (control group). " 01/01/2015 - "Evaluation of effects of Maṇḍurabhasma on structural and functional integrity of small intestine in comparison with ferrous sulfate using an experimental model of iron deficiency anemia." 07/01/2008 - "Comparison of ferrous sulfate and ferrous glycinate chelate for the treatment of iron deficiency anemia in gastrectomized patients." 03/06/2008 - "Prophylaxis for iron deficiency anemia using ferrous sulfate among infants followed up at a primary healthcare unit in the municipality of Embu-SP (2003/2004)."
10.	Heme (Haem)IBA 05/28/1976 - "Early labeled heme synthesis in normal rats and rats with iron deficiency anemia." 12/01/1970 - "[Disturbances of heme synthesis in iron deficiency anemia]." 02/01/2006 - "Iron-deficiency anemia (anemia with erythrocyte protoporphyrin (EP) > or =90 micromol/mol heme) was present in 43% of the children. " 01/01/1992 - "The quantitation of the non-heme porphyrin content of circulating erythrocytes is an important tool in the screening, diagnosis, and management of lead disease, iron deficiency anemia, and certain porphyrias. " 07/01/2005 - "The study has been carried out to find out the value of disorders of heme synthesis and heme disintegration processes taking place in liver in patients with iron-deficiency anemia as well as in connection with the activity of detoxication enzymes."

Therapies and Procedures

1.	Renal Dialysis (Hemodialysis) 11/01/2001 - "Our study featured ten hemodialysis patients with iron deficiency anemia. " 06/20/1992 - "Thirty six of them in hemodialysis (HD), 10 in continuous ambulatory peritoneal dialysis (CAPD) and 18 in predialysis stage (PD) and their results were compared to two control groups, including 72 healthy controls (HC) and the second one 89 iron deficiency anemia patients (ID). " 01/01/2006 - "Participants of the study were reference subjects (n=75), subjects with iron deficiency anemia (n=52), subjects with uremia (n=19) and subjects undergoing hemodialysis treatment (n=43). " 01/01/2006 - "For the ratio of RET-He and RBC-He obviously decreased results are demonstrated in case of subjects with iron deficiency anemia (1.02 +/- 0.08, mean +/- SD), hemodialysis (1.05 +/- 0.05) and uremia (1.02 +/- 0.10) if compared with the group of reference subjects (1.11 +/- 0.02). " 10/01/2000 - "Iron deficiency anemia is common in patients with chronic renal failure not undergoing hemodialysis. "
2.	Aftercare (After-Treatment) 10/01/2009 - "Linear growth in children with iron deficiency anemia before and after treatment." 10/01/1975 - "[Dynamics of microcyte in iron deficiency anemia before and after treatment (author's transl)]." 07/16/2015 - "We aimed to investigate the effects of iron deficiency anemia (IDA) and vitamin B12 deficiency coexisting with IDA which is called as mixed anemia (MA) on hemorheological parameters, to compare them with each other and healthy controls, and to assess the changes in hemorheological parameters after treatment. " 06/01/2011 - "In the present study, we determined the prevalence of iron deficiency anemia in children with behavioural disorders and assessed the improvement in terms of symptoms (by child behaviour check list), haematological parameters and iron status after treatment with oral iron. " 10/01/2014 - "We aimed to investigate the effects of iron deficiency (ID) or iron-deficiency anemia (IDA) on oxidative stress and renal tubular functions before and after treatment of children. "
3.	Low-Level Laser Therapy (LLLT) 05/01/2014 - "The efficacy of the use of IR laser phototherapy (LPT) on bone defect grafted with biphasic ceramic on rats with iron deficiency anemia: Raman spectroscopy analysis."
4.	Parenteral Nutrition 10/01/2002 - "Twenty-two infants and children aged 5 months-17 years (median: 38 months) receiving long-term parenteral nutrition and presenting with iron deficiency anemia were included. " 10/01/2002 - "Tolerance and efficacy of intravenous iron saccharate for iron deficiency anemia in children and adolescents receiving long-term parenteral nutrition."
5.	Blood Transfusion (Blood Transfusions) 09/01/2015 - "However, many clinical studies have suggested that delayed cord clamping is associated with various neonatal benefits including increased blood volume, reduced need for blood transfusion, increased cerebral oxygenation in pre-term infants, and decreased frequency of iron deficiency anemia in term infants. " 01/01/2013 - "The associated blood loss can be chronic, resulting in iron deficiency anemia which, when severe, has historically been treated by blood transfusions. " 09/01/2012 - "Almost 30 sessions of excessive cupping therapies with blood loss over two months yielded little benefit but led the patient to admit a hospital and receive blood transfusion for acquired iron deficiency anemia. " 05/01/2003 - "We describe a patient who had typical Sjögren's syndrome and iron deficiency anemia requiring blood transfusion. " 10/01/2000 - "The presenting symptom was iron deficiency anemia, which in 11 cases was severe enough to require blood transfusions. "