Senotherapeutics

Chemical agents which induce the removal (by apoptotic or non-apoptotic cell death) or immune-mediated clearance of senescent cells, or the neutralization of the detrimental effects of the SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE.

Also Known As:

Agents, Seno-Therapeutic; Agents, Senolytic; Agents, Senomorphic; Agents, Senoptotic; Agents, Senostatic; Agents, Senotherapeutic; Inducers, Senoptosis; Seno Therapeutic Agents; Geroprotectors; Seno-Therapeutic Agents; Senolytic Agents; Senolytics; Senomorphic Agents; Senomorphics; Senoptosis Inducers; Senoptotic Agents; Senoptotics; Senostatic Agents; Senostatics; Senotherapeutic Agents

Networked: 231 relevant articles (31 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Senotherapeutics: 231

Experts

1.	Kirkland, James L: 18 articles (01/2022 - 08/2015)
2.	Tchkonia, Tamara: 8 articles (01/2022 - 08/2015)
3.	Khosla, Sundeep: 8 articles (11/2021 - 08/2015)
4.	Zhu, Yi: 8 articles (11/2021 - 08/2015)
5.	Tchkonia, Tamar: 7 articles (01/2022 - 01/2019)
6.	LeBrasseur, Nathan K: 6 articles (11/2021 - 08/2015)
7.	Niedernhofer, Laura J: 6 articles (11/2021 - 08/2015)
8.	Gewirtz, David A: 5 articles (01/2022 - 02/2021)
9.	Passos, João F: 5 articles (01/2022 - 01/2019)
10.	Xu, Ming: 5 articles (01/2022 - 01/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "The identification of senolytics, compounds that eliminate senescent cells, is presently a key priority given their therapeutic promise in cancer and aging-associated diseases. " 07/01/2001 - "Thus, the efficacy of geroprotectors as preventive means of cancer development will decrease with respect to the age of exposure onset. " 11/29/2023 - "In this review, we highlight emerging evidence supporting the use of senolytic agents to ablate latent, senescent-like cells that could contribute to tumor recurrence. " 01/01/2023 - "Thus, conventional cancer treatments, incapable of eliminating senescence, may benefit if revisited to include senolytic agents. " 01/01/2023 - "Our data demonstrate that BCL-XL is critical for survival of senescent PA tumor cells and provides proof-of-principle for the use of clinically available BCL-XL-dependent senolytics."
2.	Osteoporosis 01/01/2020 - "This suggests that promoting the selective removal of senescent cells, via the use of senolytic agents, can be beneficial in the treatment of aging-related bone loss and osteoporosis. " 01/01/2023 - "Taken together, the bone-targeted delivery of senolytics efficiently eliminates senescent cells to recover bone mass and microarchitecture, showing an effective treatment for senile osteoporosis. " 01/01/2023 - "Therefore, we developed a bone-targeted delivery system for senolytics to effective treatment of senile osteoporosis. " 01/01/2023 - "Bone-targeted delivery of senolytics to eliminate senescent cells increases bone formation in senile osteoporosis." 10/01/2021 - "The role of senolytics in osteoporosis and other skeletal pathologies."
3.	Chronic Disease (Chronic Diseases) 10/22/2023 - "Due to its proper characteristics, KOA represents a favorable disease model for experimenting with senotherapeutics, a group of treatments that counteract the development of age-related disorders and chronic diseases. " 01/01/2022 - "Hence, senolytics and other geroscience interventions that may prolong healthspan and alleviate chronic diseases and multimorbidity linked to fundamental aging processes might be an option for delaying, preventing, or alleviating Long-Hauler's Syndrome." 10/01/2021 - "Collectively, there is demand for research to develop targeted senotherapeutics that address the needs of the aging and chronically-ill." 01/01/2021 - "Hopefully, these or other senolytic agents may provide novel ways to prevent and treat different chronic diseases in man. " 01/01/2021 - "Senolytics, drugs that eliminate senescent cells, afford new therapeutic strategies for control of these chronic diseases."
4.	Inflammation (Inflammations) 11/13/2023 - "Here we show that senescent cells accumulate in aged human brain organoids and that senolytics reduce age-related inflammation and rejuvenate transcriptomic aging clocks. " 01/01/2023 - "Noteworthy, Sesns activate senolytics, which are agents that selectively eliminate senescent cells, as well as specialized pro-resolving mediators, which are factors that physiologically provide inflammation resolution. " 01/01/2023 - "Senotherapeutics are drugs that target cellular senescence through senolytic and senomorphic functions to induce apoptosis and suppress chronic inflammation caused by the senescence-associated secreted phenotype (SASP), respectively. " 01/01/2022 - "Mechanisms of ageing such as senescence, inflammation and autophagy are common drivers for both diseases and molecules targeting those mechanisms (geroprotectors) have potential to prevent both diseases and their co-morbidities. " 01/01/2019 - "Our results implicate cellular senescence as a causal factor in obesity-related inflammation and metabolic derangements and show that emerging senolytic agents hold promise for treating obesity-related metabolic dysfunction and its complications."
5.	COVID-19 11/13/2023 - "In human-ACE2-overexpressing mice, senolytics improved COVID-19 clinical outcomes, promoted dopaminergic neuron survival and alleviated viral and proinflammatory gene expression. " 01/01/2023 - "Senolytics combat COVID-19 in aging." 11/01/2021 - "[Senolytics against Covid-19?]" 03/30/2020 - "Therefore, we wish to speculate that the fight against COVID-19 disease should involve testing the hypothesis that senolytics and other anti-aging drugs may have a prominent role in preventing the transmission of the virus, as well as aid in its treatment. " 11/30/2021 - "We highlight that senolytics, which eliminate senescent cells, can target aging-associated pathways and therefore are proving attractive as potential therapeutic options to alleviate symptoms, prevent severe infection, and reduce mortality burden in COVID-19 and thus ultimately enhance healthspan."

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Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation
3.	Immunotherapy
4.	Drug Therapy (Chemotherapy)
5.	Radiotherapy