Diterpene Alkaloids

Alkaloids derived from diterpenes (e.g., KAURANES; CLERODANES) often containing the nitrogen bridge structures. These alkaloids may be divided into C18-, C19-, C20- and bis-diterpene types depending on the number of carbon atoms in their central framework. They are found most often in RANUNCULACEAE (e.g., ACONITUM and DELPHINIUM) and may possess analgesic, antiarrhythmic and anti-inflammatory activities. Some are cardiotoxic by blocking L-TYPE CALCIUM CHANNELS.

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Networked: 19 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nesterova, Yu V: 5 articles (05/2016 - 08/2011)
2.	Suslov, N I: 5 articles (05/2016 - 08/2011)
3.	Zyuz'kov, G N: 4 articles (05/2016 - 03/2014)
4.	Dygai, A M: 3 articles (05/2016 - 01/2015)
5.	Losev, E A: 3 articles (05/2016 - 01/2015)
6.	Minakova, M Yu: 3 articles (05/2016 - 01/2015)
7.	Miroshnichenko, L A: 3 articles (05/2016 - 01/2015)
8.	Povet'eva, T N: 3 articles (05/2016 - 01/2015)
9.	Simanina, E V: 3 articles (05/2016 - 01/2015)
10.	Udut, E V: 3 articles (05/2016 - 01/2015)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2018 - "Paclitaxel (Tax) is a diterpene alkaloid isolated from Taxus species and has proved clinically effective in treating a number of malignancies. " 01/01/2018 - "Paclitaxel, a diterpene alkaloid of Taxus brevifolia, is widely used as an anti-tumor drug and shows protective effects on acute lung and kidney injury. " 01/01/2023 - "Paclitaxel (PTX) and its derivatives are diterpene alkaloids widely used as chemotherapeutic agents in the treatment of various types of cancer. " 04/26/2002 - "Paclitaxel (PTX), the diterpene alkaloid, is a potent anti-cancer drug and is routinely used for the treatment of breast and ovarian cancers. " 11/03/2017 - "A cassaine diterpene alkaloid, 3β-acetyl-nor-erythrophlamide, suppresses VEGF-induced angiogenesis and tumor growth via inhibiting eNOS activation."
2.	Cardiotoxicity 05/01/2021 - "Cardiotoxicity evaluation and comparison of diterpene alkaloids on zebrafish." 04/15/2019 - "Thus, diterpene alkaloids are the main compounds responsible for the cardiotoxicity of C. " 04/15/2017 - "Assessment of in vitro cardiotoxicity of extract fractions and diterpene alkaloids from Aconitum leucostomum Worosch: A short communication." 05/01/2021 - "Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. " 05/01/2021 - "This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaconitine (HAC) and three monoester diterpene alkaloids (MDAs) including 14-α-benzoylaconine (BAC), 14-α-benzoylmesaconine (BMAC), 14-α-benzoylhypaconine (BHAC) on zebrafish. "
3.	Brain Ischemia (Cerebral Ischemia) 04/01/2015 - "We studied the psychopharmacological effects of atisine-type diterpene alkaloid Z77 in a rat model of brain ischemia in the morning and at night. " 01/01/2015 - "We studied the psychopharmacological effects of atisine-type diterpene alkaloid Z77 in a rat model of cerebral ischemia. " 07/19/2002 - "Spiramine T, an atisine-type diterpene alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceae), was shown to have neuroprotective effects on cerebral ischemia-reperfusion injury. "
4.	Hepatocellular Carcinoma (Hepatoma) 09/29/2020 - "Therapeutic Potential of (-)-Agelamide D, a Diterpene Alkaloid from the Marine Sponge Agelas sp., as a Natural Radiosensitizer in Hepatocellular Carcinoma Models." 01/01/2017 - "A bromopyrrole-containing diterpene alkaloid from the Okinawan marine sponge Agelas nakamurai activates the insulin pathway in Huh-7 human hepatoma cells by inhibiting protein tyrosine phosphatase 1B."
5.	Breast Neoplasms (Breast Cancer) 10/01/2013 - "Bioguided discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors." 01/01/2013 - "Indole diterpene alkaloids as novel inhibitors of the Wnt/β-catenin pathway in breast cancer cells."

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	hypaconitine
3.	mesaconitine
4.	Aconitine
5.	indole
6.	Non-Receptor Type 1 Protein Tyrosine Phosphatase
7.	Catenins
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9.	Neuroprotective Agents
10.	Serotonin (5 Hydroxytryptamine)