Mechanisms of psychopharmacological effects of alkaloid Z77 under conditions of brain ischemia.

Abstract

We studied the psychopharmacological effects of atisine-type diterpene alkaloid Z77 in a rat model of brain ischemia in the morning and at night. The type of developing locomotor disorders in animals was shown to depend on circadian rhythms. Administration of Z77 substantially corrected manifestations of psychoneurological symptoms. The parameters of orientation and exploratory behavior and conditioned reflex activity were normalized. The key role of receptors of neural stem cells to fibroblast growth factor in the realization of their growth potential under the influence of the alkaloid was demonstrated. Under in vitro conditions, antibodies to fibroblast growth factor receptor abolished the increase in the number of neural CFU caused by Z77 in the culture of intact cells from the paraventricular region of the brain.

• Authors: G N Zyuz'kov, N I Suslov, E A Losev, V V Zhdanov, E V Udut, L A Miroshnichenko, E V Simanina, T N Povet'eva, Yu V Nesterova, V V Udut, M Yu Minakova, T A Zamoshchina, A M Dygai
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 158 Issue 6 Pg. 762-5 (Apr 2015) ISSN: 1573-8221 [Electronic] United States
• PMID: 25894773 (Publication Type: Journal Article)

Chemical References

• Alkaloids
• Receptors, Fibroblast Growth Factor

Topics

• Alkaloids (pharmacology, therapeutic use)
• Animals
• Brain Ischemia (drug therapy, metabolism)
• Gait Disorders, Neurologic (drug therapy, metabolism)
• Male
• Neural Stem Cells (cytology, drug effects)
• Rats
• Receptors, Fibroblast Growth Factor (metabolism)
• Regenerative Medicine (methods)