Aversive Agents

11/01/2009 - "The addition of bittering agents to household products cannot be justified based on actual poisoning data."
01/01/1994 - "The role of aversive bittering agents in the prevention of pediatric poisonings."
01/01/2000 - "While not the stated intention of the law, addition of aversive agents to consumer automotive products could also reduce adult poisonings associated with intentional (suicides or alcoholics ingesting methanol-containing windshield wiper fluid) or accidental exposures. "
03/01/1991 - "Bittering agents in the prevention of accidental poisoning: children's reactions to denatonium benzoate (Bitrex)."
11/01/2009 - "Despite the appealing logic of limiting the ingested volume and thereby the severity of poisonings by adding aversive agents, and despite promising results in volunteer studies, bittering agents do not decrease the frequency or severity of pediatric antifreeze poisonings. "

09/20/1997 - "Useful pharmacological agents for the treatment of alcohol dependence can be classified into four groups: (1) agents for the treatment of the withdrawal syndrome, (2) aversive agents, (3) therapeutic agents for comorbidity, (4) new agents to reduce craving for alcohol or prevent relapse. "
09/01/2009 - "Aversive agents, opiate antagonists, and glutamate based interventions are currently approved to treat alcohol use disorders with future promise with GABAergic, serotonergic, and endocannabinoid system agents. "

10/01/1988 - "The structural characteristics of the area postrema, its anatomical connections, participation in the detection of emesis-provoking substances and the effects of area postrema lesions on taste aversion learning acquisition, are all factors which speak in favor of a role as a chemoreceptor zone involved in the detection of aversive agents which act as effective inducers of taste aversion learning. "

12/01/1983 - "Reasoning that a satiety factor should be less inhibiting of feeding in a hungrier animal, whereas aversive agents should be unaffected by hunger, we studied the neuropharmacologic dose responses of five substances administered peripherally to rats at two different degrees of starvation. "

01/01/1975 - "A quantitative method for measuring the efficiency of pungent agents of capsaicin-type by the pain reaction elicited on the eye of rats is described. "
01/01/1975 - "Sensory effects of capsaicin congeners I. Relationship between chemical structure and pain-producing potency of pungent agents."