Dishevelled Proteins

A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.

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Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kardum, Vedran: 1 article (03/2020)
2.	Karin-Kujundzic, Valentina: 1 article (03/2020)
3.	Nikuseva-Martic, Tamara: 1 article (03/2020)
4.	Paic, Frane: 1 article (03/2020)
5.	Serman, Alan: 1 article (03/2020)
6.	Serman, Ljiljana: 1 article (03/2020)
7.	Skenderi, Faruk: 1 article (03/2020)
8.	Skrtic, Anita: 1 article (03/2020)
9.	Sola, Ida Marija: 1 article (03/2020)
10.	Vranic, Semir: 1 article (03/2020)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2009 - "Dishevelled proteins are key regulators of Wnt signaling pathways that have been implicated in the progression of human cancers. " 03/01/2020 - "To get deeper insight into the behavior of Dishevelled proteins in cancer, we studied their expression in serous ovarian carcinomas [both low- (LGSC) and high-grade (HGSC)], and HGSC cell lines OVCAR5, OVCAR8, and OVSAHO. " 01/15/2007 - "An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth."
2.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 05/01/2019 - "[Expression and significance of dishevelled proteins in the Wnt pathway in childhood acute lymphoblastic leukemia]."
3.	Neoplasm Metastasis (Metastasis) 01/01/2017 - "WWC3 regulates the Wnt and Hippo pathways via Dishevelled proteins and large tumour suppressor 1, to suppress lung cancer invasion and metastasis."
4.	Lung Neoplasms (Lung Cancer) 01/01/2017 - "WWC3 regulates the Wnt and Hippo pathways via Dishevelled proteins and large tumour suppressor 1, to suppress lung cancer invasion and metastasis."
5.	Carcinoma (Carcinomatosis) 03/01/2020 - "To get deeper insight into the behavior of Dishevelled proteins in cancer, we studied their expression in serous ovarian carcinomas [both low- (LGSC) and high-grade (HGSC)], and HGSC cell lines OVCAR5, OVCAR8, and OVSAHO. "

Related Drugs and Biologics

1.	beta Catenin
2.	Proteins (Proteins, Gene)