Pancreatic Polypeptide

A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.

Also Known As:

Pancreatic Polypeptide (PP); Pancreatic Polypeptide Hormone; Pancreatic Prohormone

Pharmalogical Action Categories:

Gastrointestinal Agents
Hormones

Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Pancreatic Hormones: 113
      - Pancreatic Polypeptide: 791
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Pancreatic Polypeptide: 791
- Peptides: 82426
  - Neuropeptides: 6772
    - Pancreatic Polypeptide: 791
  - Peptide Hormones: 1347
    - Pancreatic Hormones: 113
      - Pancreatic Polypeptide: 791

PP 1420

Bio-Agent Context: Research Results