Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency

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Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pancytopenia
2.	Hypertension (High Blood Pressure)
3.	Anemia

Experts

1.	Smith, Desirée E C: 2 articles (02/2011 - 02/2011)
2.	Cai, Hua: 1 article (01/2019)
3.	Li, Qiang: 1 article (01/2019)
4.	Murugesan, Priya: 1 article (01/2019)
5.	Siu, Kin Lung: 1 article (01/2019)
6.	Youn, Ji Youn: 1 article (01/2019)
7.	Zhang, Yixuan: 1 article (01/2019)
8.	Ayric, Zuleya: 1 article (02/2011)
9.	Aziz, Majid: 1 article (02/2011)
10.	Banka, Siddharth: 1 article (02/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency:

1.	Leucovorin (Folinic Acid)FDA Link 02/11/2011 - "In conclusion, the homozygous DHFR mutation p.Asp153Val causes DHFR deficiency and leads to a complex hematological and neurological disease that can be successfully treated with folinic acid. " 02/11/2011 - "We show that cerebral folate levels, anemia, and pancytopenia of DHFR deficiency can be corrected by treatment with folinic acid. "
2.	Folic Acid (Vitamin M)FDA LinkGeneric 02/11/2011 - "The patients' folate profile in red blood cells (RBC), plasma, and cerebrospinal fluid (CSF), analyzed by liquid chromatography tandem mass spectrometry, was compatible with DHFR deficiency. " 02/11/2011 - "We show that cerebral folate levels, anemia, and pancytopenia of DHFR deficiency can be corrected by treatment with folinic acid. "
3.	Reactive Oxygen Species (Oxygen Radicals)IBA 01/01/2019 - "Importantly, scavenging of mitochondrial reactive oxygen species with Mito-Tempo in vivo completely abrogated development of hypertension and AAA in DHFR knockout mice, indicating a novel role of mitochondria in mediating hypertension and AAA downstream of DHFR deficiency-dependent eNOS uncoupling. "
4.	EnzymesIBA 04/01/2000 - "parvum, Plasmodium falciparum, Toxoplasma gondii, Pneumocystis carinii, and humans in the same DHFR-deficient yeast strain and observed that each heterologous enzyme complemented the yeast DHFR deficiency. "
5.	DNA (Deoxyribonucleic Acid)IBA 02/01/1983 - "Both of these minigenes complemented the DHFR deficiency in Chinese hamster ovary dhfr-1-cells at a high frequency after DNA-mediated gene transfer. "
6.	TEMPOIBA 01/01/2019 - "Importantly, scavenging of mitochondrial reactive oxygen species with Mito-Tempo in vivo completely abrogated development of hypertension and AAA in DHFR knockout mice, indicating a novel role of mitochondria in mediating hypertension and AAA downstream of DHFR deficiency-dependent eNOS uncoupling. "