Sterol 14-Demethylase

An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.

Also Known As:

CYP51 Cytochrome P-450; Cytochrome P-450 CYP51; Eburicol 14 alpha-Demethylase; Eburicol 14alpha-Demethylase; Lanosterol 14 alpha-Demethylase; Obtusifoliol 14alpha-Demethylase; Sterol 14-alpha-Demethylase; 14 alpha-Demethylase, Eburicol; 14 alpha-Demethylase, Lanosterol; 14-Demethylase, Sterol; 14-Demethylases, Sterol; 14-alpha-Demethylase, Sterol; 14alpha-Demethylase, Eburicol; 14alpha-Demethylase, Obtusifoliol; CYP51 Cytochrome P 450; CYP51, Cytochrome P-450; Cytochrome P 450 CYP51; Cytochrome P-450, CYP51; Eburicol 14 alpha Demethylase; Eburicol 14alpha Demethylase; Lanosterol 14 alpha Demethylase; Obtusifoliol 14alpha Demethylase; P-450 CYP51, Cytochrome; P-450, CYP51 Cytochrome; Sterol 14 Demethylase; Sterol 14 Demethylases; Sterol 14 alpha Demethylase; Sterol 14-Demethylases

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Cytochrome P-450 Enzyme System: 5365
        Steroid Hydroxylases: 11
        Sterol 14-Demethylase: 5
        Cytochrome P450 Family 51: 1
        Sterol 14-Demethylase: 5
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - Steroid Hydroxylases: 11
      - Sterol 14-Demethylase: 5
    - Cytochrome P450 Family 51: 1
      - Sterol 14-Demethylase: 5
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Hemeproteins: 194
    - Cytochromes: 2196
      - Cytochrome P-450 Enzyme System: 5365
        Steroid Hydroxylases: 11
        Sterol 14-Demethylase: 5
        Cytochrome P450 Family 51: 1
        Sterol 14-Demethylase: 5

rat Cyp51 protein

Bio-Agent Context: Research Results