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demalonyl thyrsiflorin A

induces apoptosis and necrosis in epithelial cancer cells; structure in first source

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - demalonyl thyrsiflorin A: 2

Experts

1.	Cardile, V: 2 articles (03/2018 - 09/2007)
2.	Piovano, M: 2 articles (03/2018 - 09/2007)
3.	Russo, A: 2 articles (03/2018 - 09/2007)
4.	Avola, R: 1 article (03/2018)
5.	Graziano, A C E: 1 article (03/2018)
6.	Chamy, M C: 1 article (09/2007)
7.	Garbarino, J A: 1 article (09/2007)
8.	Lombardo, L: 1 article (09/2007)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 09/20/2007 - "Therefore, the present study was undertaken to investigate the effect of the semisynthetic compound, demalonyl thyrsiflorin A, on cell growth and death in two human epithelial cell lines, DU-145 cells (androgen-insensitive prostate cancer cells) and KB cells (oral squamous carcinoma cells). "
2.	Melanoma (Melanoma, Malignant) 03/01/2018 - "The present study was undertaken to investigate the effect of the semisynthetic compound, demalonyl thyrsiflorin A on human melanoma cells. " 03/01/2018 - "Cytotoxicity of demalonyl thyrsiflorin A, a semisynthetic labdane-derived diterpenoid, to melanoma cells."
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 09/20/2007 - "Therefore, the present study was undertaken to investigate the effect of the semisynthetic compound, demalonyl thyrsiflorin A, on cell growth and death in two human epithelial cell lines, DU-145 cells (androgen-insensitive prostate cancer cells) and KB cells (oral squamous carcinoma cells). "
4.	Necrosis 03/01/2018 - "Alternatively, the inhibition of the caspase cascade at higher concentrations, 25 and 50μM, correlated with additional reactive oxygen species increase, probably switched the mode of demalonyl thyrsiflorin A-induced cell death from apoptosis to necrosis." 09/20/2007 - "Demalonyl thyrsiflorin A, a semisynthetic labdane-derived diterpenoid, induces apoptosis and necrosis in human epithelial cancer cells."
5.	Neoplasms (Cancer) 09/20/2007 - "Demalonyl thyrsiflorin A, a semisynthetic labdane-derived diterpenoid, induces apoptosis and necrosis in human epithelial cancer cells."

Related Drugs and Biologics

1.	Androgens
2.	Diterpenes
3.	labdane
4.	Caspases
5.	Reactive Oxygen Species (Oxygen Radicals)