Thomas' solution

05/01/2010 - "In comparison with STS group, St. Thomas solution containing PolyHb improved the recovery of LVDP (P < 0.001) and +/- dp/dt (P < 0.001), decreased the release of CK and LDH (P < 0.001), reduced the percentage of the infarct size (P < 0.001) of the heart during reperfusion as well. "
02/01/2010 - "Compared with standard St Thomas solution alone, adding 30% Intralipid alone also significantly reduced the infarct size and the CK-MB leakage and improved the recovery of the mechanical function. "
02/01/2009 - "Compared with St. Thomas' solution (STS) and rat self blood in STS, polymerized placenta hemoglobin (PolyPHb) in STS greatly improved heart contraction and decreased infarction size. "

08/01/1995 - "To define the early phase of recovery that had been obscured by reperfusion-induced arrhythmias, we repeated the experiments with the inclusion of a cardioplegic infusion (St Thomas' solution for 2 minutes before ischemia). "
03/01/1996 - "Study 2: the effect of preconditioning added to cardioplegia with four groups subjected to 35 min ischemia (n = 8/group): (i) controls, (ii) one cycle of preconditioning (3 min ischemia + 3 min reperfusion), (iii) cardioplegia with St Thomas' solution immediately prior to ischemia, and (iv) preconditioning followed by cardioplegia prior to ischemia. "
05/01/1996 - "Four groups (n=8 hearts per group) were studied: control hearts with 35 minutes of unprotected ischemia, hearts preconditioned with one cycle of 3 minutes of ischemia plus 3 minutes of reperfusion before 35 minutes of ischemia, hearts subjected to cardioplegia with St Thomas' solution infused for 1 minute before 35 minutes of ischemia, and hearts subjected to preconditioning plus cardioplegia before 35 minutes of ischemia. "
01/01/1981 - "Multidose (every 40 minutes) cardioplegic infusion of the St. Thomas' solution combined with topical hypothermia extended the tolerable period of ischemia from less than 30 minutes to about 120 minutes in the rat and from less than 60 minutes to more than 180 minutes in the dog. "
05/01/2003 - "Pinacidil provided better protection during ischemia-reperfusion in the immature rabbit heart than St. Thomas' solution, whereas pinacidil combined with St. Thomas' solution showed the worst protective effects in immature hearts."

01/01/2016 - "In conclusion, HTK solution seems to be an effective and safe alternative to St. Thomas' solution for cardioplegic reperfusion in high-risk patients with complex congenital heart disease. "

03/01/1999 - "This study tested the hypothesis that cardiac arrest achieved with BDM would be as effective as that achieved with St. Thomas' solution (StT). "
12/01/1994 - "Intraoperative cardiac arrest was achieved using an average of 1,254 +/- 14 mL of St. Thomas' solution in multiple doses. "
07/01/1993 - "We start the SCP at the initiation of total cardiopulmonary bypass, routinely associated to an aortic clamp and cardiac arrest under myocardial protective procedure that is the use of perfusion cooling (30 degrees C, monitored at the esophagus), topical cooling and cold Saint Thomas solution infused in the coronary arteries. "
09/01/1998 - "In all cases, moderate hypothermia and cardioplegic(St. Thomas solution) cardiac arrest were performed. "
01/01/1999 - "In group B (n = 6), the hearts were perfused with cold (4 degrees C) St. Thomas' solution 60 min after cardiac arrest and preserved in cold UW solution. "

07/16/2023 - "This study aims to describe the application of a modified St. Thomas' solution in patients with severe limb injuries. "
07/16/2023 - "Pretreatment with a modified St. Thomas' solution in patients with severe upper limb injuries: Four case reports."
07/16/2023 - "Four patients who sustained a high-energy trauma and underwent complete upper limb amputation were pretreated with a modified St. Thomas' solution before upper limb replantation. "