Factor VII Padua

abnormal factor VII; Gln replaces Arg-304; this mutation has been postulated to reduce the catalytic function by removing a positive charge in a portion of the catalytic domain surrounded by a charged variable loop

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bertozzi, I: 1 article (09/2011)
2.	Bonamigo, E: 1 article (09/2011)
3.	Fabris, F: 1 article (09/2011)
4.	Girolami, A: 1 article (09/2011)
5.	de Marinis, G Berti: 1 article (09/2011)
6.	Dlott, Jeffrey S: 1 article (01/2010)
7.	Fu, Sidney W: 1 article (01/2010)
8.	Kirkel, Dean: 1 article (01/2010)
9.	Lin, Ta-Wei: 1 article (01/2010)
10.	McCaffrey, Timothy: 1 article (01/2010)

Related Diseases

1.	Factor VII Deficiency (Hypoproconvertinemia) 09/01/2011 - "Activated FVII levels in factor VII Padua (Arg304Gln) coagulation disorder and in true factor VII deficiency: a study in homozygotes and heterozygotes." 01/01/2010 - "Factor VII Padua is a variant form of factor VII deficiency characterized by a prolongation of the prothrombin time (PT), when the assay is performed using rabbit brain thromboplastin. "
2.	von Willebrand Diseases (von Willebrand's Disease) 02/01/1993 - "We report a family with a combined factor VII Padua defect and von Willebrand's disease (vWd). " 02/01/1993 - "First report of combined factor VII Padua defect and von Willebrand's disease due to casual association of the two defects." 07/01/1992 - "A G-to-A transition, which gives rise to a missense mutation, Arg-304 to Gln, and is associated with the factor VII padua variant, was found in the heterozygous form in a subject also affected by von Willebrand disease. "
3.	Hemorrhage 02/01/1993 - "The propositus is a 9-year-old child with a moderate bleeding tendency who appeared to be heterozygous for both factor VII Padua and type I vWd. "

Related Drugs and Biologics

1.	Thromboplastin (Tissue Factor)