mono-(2-ethylhexyl)phthalate

04/18/2024 - "Increased serum, urinary, or dietary concentration of MBzP and MEHP in women is significantly associated with endometriosis risk. "
06/01/2010 - "The positive associations for MBP and inverse associations for MEHP in relation to endometriosis and leiomyomata warrant investigation in prospective studies."
06/01/2010 - "Findings for MEHHP and MEOHP agreed with findings for MEHP with respect to endometriosis only. "
12/15/2009 - "Adjusted odds ratio (95% confidence interval) for higher dichotomized MEHP by endometriosis was 1.57 (0.74-3.30). "
12/01/2014 - "In contrast, patients with endometriosis or adenomyosis showed a marginally increased level of urinary MEHP only. "

05/01/2024 - "In addition, we found that exogenous LPS synergized with MEHP could activate the NF-κB signaling pathway to induce inflammation and apoptosis of GCs in a relatively prolonged exposure condition. "
12/01/2023 - "The inner MEHP exhibits superior mechanical performance, adhesion strength, and outstanding antioxidation, anti-inflammation, and antibacterial properties, and it can adhere to the injury site offering a favorable microenvironment for tendon regeneration. "
03/15/2022 - "High levels of MEHP, MBzP and MBP increased the odds of depressive symptoms in the elderly, and chronic inflammation had a partial mediating effect on the increased odds of depressive symptoms due to MEHP exposure."
01/01/2018 - "MEHP-induced rat testicular inflammation does not exacerbate germ cell apoptosis."
11/01/2014 - "From a functional standpoint, inhibition of endogenous Mta1 expression along with anti-inflammation treatment in cultured SCs could rescue MEHP-inhibited TIMP2 and subsequently rebalanced MMP2 activity to the control level. "

04/27/2024 - "Cell viability and gene expression profile were investigated following 7 days of MEHP exposure using the human granulosa cancer cell lines KGN, and COV434, the germline tumor cell line PA-1, and human ovarian primary cells. "
08/01/2019 - "Emerging evidences showed that MEHP can regulate the progression of various cancers. "
03/01/2001 - "Effect of mono-ethylhexyl phthalate on MA-10 Leydig tumor cells."
02/20/2024 - "We exposed MYCN-amplified neuroblastoma SK-N-BE(2)C cells to an environmentally related concentration of MEHP and found that MEHP increased the proliferation and migration ability of tumor cells. "
11/01/2021 - "In the present study, we examined the effects of MEHP on changes in mitochondrial function in relationship to reduced progesterone formation by MA-10 mouse tumor Leydig cells. "

06/30/2022 - "The highest concentrations were found in neonates having the lowest body weight, which is concerning, knowing the adverse effects of MEHP in infants. "
06/01/2021 - "The animals fed on the MEHP diet had a maximum DM and nutrient intakes (CP and organic matter) and the best final body weight (FBW), total gain, gain rate, average daily gains, and feed conversion efficiency (31.3, 12.9 kg, 41.2%, 143.3 gm, and 23.13, respectively), followed by HEMP, HEHP, MEMP, and mEmP diets. "
03/01/2010 - "The body weight gain was significantly lower in rats treated with BBP, DBP, DINP, MEHP, MBuP, and PA than that of control. "
05/01/2006 - "The ranges of the estimated daily intake of DEHP per body weight based on the MEHP, MEOHP and MEHHP concentrations (n=40) were 3.45-41.6 (median 10.4), 0.66-17.9 (median 4.55) and 1.47-8.57 (median 3.51) microg/kg/day, respectively. "
03/01/2004 - "The maximum concentrations of MEHP in blood of marmosets were up to 7.5 times and the normalized AUCs up to 16 times lower than in rats receiving the same daily oral DEHP dose per kilogram of body weight. "

12/01/2012 - "These results suggest that perinatal exposure to MEHP may be expected to increase the incidence of obesity in a sex-dependent manner and can act as a potential chemical stressor for obesity and obesity-related disorders."
11/01/2018 - "MBzP and MEHP were significantly associated with obesity, elevated levels of triglyceride and blood pressure. "
03/01/2018 - "Mono(2-ethylhexyl) phthalate (MEHP) is the bioactive metabolite of di(2-ethylhexyl) phthalate, a plasticizing agent and persistent environmental contaminant associated with obesity, developmental abnormalities, and oxidative stress. "
05/25/2009 - "A thorough analysis of its interactions with PPARgamma identified MEHP as a selective PPARgamma modulator, and thus a possible contributor to the obesity epidemic."
01/01/2017 - "DEHP and its primary metabolite mono-(2-ethyl hexyl)phthalate (MEHP) posed a considerable interest because of their contribution to insulin resistance, type-2 diabetes and obesity. "