Endometriosis (Adenomyosis)

A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.

Also Known As:

Networked: 8242 relevant articles (589 outcomes, 1493 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Pelvic Pain
3.	Endometriosis (Adenomyosis)
4.	Infertility (Sterility)
5.	Leiomyoma (Uterine Fibroids)

Experts

1.	Guo, Sun-Wei: 54 articles (11/2015 - 08/2005)
2.	Osuga, Yutaka: 49 articles (10/2015 - 03/2003)
3.	Arici, Aydin: 44 articles (07/2013 - 01/2002)
4.	Ferrero, Simone: 43 articles (11/2015 - 01/2004)
5.	Taketani, Yuji: 39 articles (01/2014 - 03/2003)
6.	Remorgida, Valentino: 38 articles (01/2015 - 01/2004)
7.	Donnez, Jacques: 37 articles (04/2014 - 01/2002)
8.	Koga, Kaori: 36 articles (10/2015 - 07/2003)
9.	Bulun, Serdar E: 36 articles (10/2015 - 03/2002)
10.	Petraglia, Felice: 36 articles (09/2015 - 04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Endometriosis:

1.	Gonadotropin-Releasing Hormone (GnRH)FDA Link 04/01/1989 - "Two of the five patients became pregnant during cycles 2 and 5. From these results, we conclude that continuous sc infusion of GnRH-A is highly effective for complete suppression of the pituitary-ovarian function in patients with endometriosis. " 02/01/1996 - "To assess the efficacy of GnRH-agonist therapy in the treatment of endometriomas with or without surgical intervention, 26 women with laparoscopically proven endometriomas larger than 3 cm were recruited to the study. " 06/01/1997 - "Our study suggests that the 'three-step' therapy of endometriosis with GnRH-agonist buserelinacetate leads to a significant improvement on the quality of life and well being in the majority of the patients and to a high pregnancy rate. " 09/01/2015 - "Hormonal add-back successfully preserved bone health and improved quality of life for adolescents and young women with endometriosis during 12 months of gonadotropin-releasing hormone agonist therapy. " 12/01/2013 - "So, we concluded that in FET, long-term GnRH agonist pretreatment significantly improved pregnancy outcomes in patients with adenomyosis."
2.	Danazol (Azol)FDA LinkGeneric 03/01/1989 - "Although the high pretreatment level of serum CA 125 decreased after danazol treatment of 400 mg/day to within the normal limits, usually within 4 to 12 weeks, laparoscopic examinations indicated that most of the endometriosis cases were not cured until 12-16 weeks of danazol treatment." 01/01/1979 - "Based on "second look" pelviscopic control in 438 cases of pelvic endometrosis, additional hormonal antigonadotrophin therapy with danazol represents the most effective treatment for endometriosis. " 07/01/1976 - "Nineteen of the 40 patients in the study had a secondary diagnosis of pelvic endometriosis confirmed histologically, and all these patients showed a marked improvement of symptoms during the Danazol treatment. " 10/15/1981 - "The results of large clinical studies suggest that danazol treatment produces significant improvement in the symptoms, signs, and laparoscopic findings of endometriosis. " 11/01/1990 - "This review suggests that endometrioma of the intestine requires a high index of suspicion for diagnosis and that danazol does not appear to be effective treatment for these patients."
3.	Leuprolide (Lupron)FDA LinkGeneric 01/01/1992 - "On the basis of this study, it can be concluded that leuprorelin acetate treatment is safe, well tolerated and effective in the medical management of endometriosis and endometriosis-related complaints." 10/01/1991 - "Although prolonged leuprolide therapy was clinically effective, its cost and the difficulty in early diagnosis of endometriosis may limit its use in nonhuman primate medicine." 03/01/2015 - "Leuprolide acetate is effective and safe in the treatment of endometriosis." 01/01/1994 - "The study results confirm the efficacy of leuprorelin acetate depot in the treatment of even advanced stages of endometriosis." 10/01/2015 - "In this study, we performed genome-wide gene expression profiling of clinical specimens of ovarian endometrioma to obtain insight into the effects of leuprolide acetate treatment. "
4.	Estrogens (Estrogen)FDA Link 01/01/2008 - "Menstrual suppressive therapy with the use of continuous combination estrogen/progestin is the main treatment for most adolescents with endometriosis. " 01/01/2000 - "Effective treatment of endometriosis by combination estrogen-progestin pills may involve the suppression of such inflammatory responses." 06/01/2013 - "It is well established that endometriosis grows and regresses in an estrogen-dependent fashion and the disease can be effectively cured by definitive surgery. " 01/01/2003 - "The efficacy of anti-estrogens for endometriosis, an estrogen-dependent disorder, has not been demonstrated. " 01/01/2016 - "In preclinical studies, these synergistic effects of TSEC on ERα inhibition also suppressed the estrogen-dependent progression of endometriosis. "
5.	Levonorgestrel (Plan B)FDA LinkGeneric 12/01/2015 - "The levonorgestrel-releasing intrauterine system (LNG-IUS) is effective for the medical treatment of adenomyosis. " 07/01/2011 - "The levonorgestrel (LNG) intrauterine system (LNG-IUS) has been shown to improve symptoms in women with minimal to moderate endometriosis. " 12/01/2006 - "To investigate the clinical efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of adenomyosis. " 08/01/2005 - "To assess the clinical efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of adenomyosis. " 12/01/2006 - "[Clinical study of levonorgestrel-releasing intrauterine system for adenomyosis]."
6.	HormonesIBA 01/01/2009 - "Patients with severe extraperitoneal endometriosis require rapid remission and cannot wait for the effects of oral contraceptive hormones (OCs) to appear. " 01/01/2003 - "Gonadotrophin-releasing hormone analogues (GnRHas) are generally well tolerated, and are effective in relieving the symptoms of endometriosis (Prentice 2003). " 03/01/1995 - "Intraspinal endometriosis was confirmed by gynecological demonstration of additional endometriosis of the left ovary as well as positive response to treatment with a gonadotrophin releasing hormone analog. " 04/01/1987 - "It is suggested that peritoneal fluid steroid hormone assays are not helpful in the evaluation of ovarian function in endometriosis." 03/01/2015 - "We performed a systematic literature search using the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, and Ovid MEDLINE In-Process & Other Non-Indexed Citations databases to identify studies comparing the rate of change in levels of serum anti-Müllerian hormone (AMH) at 3 months after laparoscopic endometrioma excision using bipolar dessication (BD) or suturing/application of a hemostatic sealant (HS) for hemostasis. "
7.	Nafarelin (Synarel)FDA Link 08/01/1994 - "These results show the high efficacy of nafarelin in endometriosis treatment." 12/01/1997 - "Therapeutic efficacy and bone mineral density response during and following a three-month re-treatment of endometriosis with nafarelin (Synarel)." 05/01/1995 - "A 3-month course of nafarelin provided effective symptom relief for endometriosis. " 02/25/1988 - "We conclude that nafarelin is an effective agent for treating endometriosis and has few side effects other than hypoestrogenism." 06/01/2000 - "Twenty-four-week nafarelin treatment for clinical endometriosis symptoms in women < or = 29 years was safe and effective."
8.	dienogestFDA Link 01/01/2006 - "Compared with other high-dose progestin therapies, treatment with dienogest was shown to be effective even in stage IV endometriosis. " 11/01/2014 - "Dienogest, a synthetic progestin, has been shown to be effective against endometriosis, although it is still unclear as to how it affects the ectopic endometrial cells. " 10/01/2014 - "Efficacy of dienogest in the treatment of symptomatic adenomyosis: a pilot study." 12/01/2009 - "To investigate the safety and efficacy of 52 weeks of dienogest treatment in patients with endometriosis. " 09/01/2015 - "We performed a systematic literature search of randomized trials comparing dienogest to other medical therapies in the treatment of endometriosis, as well as their references list, using the keywords "dienogest" and "endometriosis" by two independent authors. "
9.	Buserelin (Suprefact)IBA 02/01/1988 - "Intranasal and subcutaneous buserelin were well accepted and equally effective in inhibiting the pituitary-ovarian function, which caused mild menopausal symptoms but an important regression of endometriosis." 01/01/2010 - "The study demonstrated that DNG is as effective as intranasal buserelin acetate in alleviating endometriosis symptoms, and causes less bone mineral density loss, resulting in the use on a commercial basis for endometriosis patients in Japan from 2008. " 03/01/1989 - "Buserelin appears to be safe, well tolerated, and effective in the management of endometriosis and associated complaints." 06/20/1986 - "The clinical findings showed Buserelin to be effective against endometriosis. " 05/01/1992 - "We performed a randomized clinical trial to evaluate the efficacy of intranasal 400 micrograms buserelin three times daily for 6 months versus expectant management in the treatment of infertile women with pelvic endometriosis stage I or II of the revised American Fertility Society classification. "
10.	Progestins (Progestagens)IBA 08/01/2015 - "For over 50 years, oral progestins have been demonstrated to be effective in the treatment of endometriosis. " 12/01/2009 - "Oral progestins have been reported to be effective in the treatment of endometriosis. " 11/01/2014 - "Aim of the present review is to present the results of clinical studies on new trends of progestins in the treatment of endometriosis." 01/01/2011 - "To avoid the several subtle modalities for distorting facts and orientating opinions in favour of specific compounds, progestins and monophasic OC used continuously are here proposed as the reference comparator in all future randomized controlled trials on medical treatment for endometriosis." 12/01/2006 - "We performed a MEDLINE and EMBASE search to identify all studies published in the English language literature on the use of progestogens for the treatment of endometriosis. "

Therapies and Procedures

1.	Cystectomy 06/01/2006 - "Partial cystectomy gives the best results when used to treat bladder endometriosis. " 01/01/2012 - "Endometrioma cystectomy leads to significant reduction in ovarian parenchyma volume and AFC, when compared to contra lateral ovary. " 01/01/2011 - "Both ovarian endometrioma and cystectomy are associated with a significant reduction on ovarian reserve. " 01/01/2012 - "We have retrospectively included 15 women with no previous ovarian surgery who benefited from cystectomy of an unilateral endometrioma the diameter of which was superior to 30mm. " 04/01/2007 - "For the treatment of ovarian endometriomas larger than 3 cm, laparoscopic cystectomy is superior to drainage and coagulation (EL1). "
2.	Hysterectomy 12/01/2014 - "Hysterectomy is a "gold standard" and definitive therapy for uterine adenomyosis, and many cases of adenomyosis have been diagnosed by pathological review retrospectively. " 01/01/1998 - "Quality evaluation and improvement in practice: Abdominal hysterectomy with or without adnexectomy for endometriosis. " 03/01/2015 - "Adenomyosis is most likely to affect adult women, although most reported incidences are still based on post-hysterectomy studies, and are affected by diligence in histopathologic diagnosis and the adopted cut-off point. " 01/01/2015 - "This study was a retrospective analysis of clinical and laboratory characteristics of 99 women who underwent hysterectomies with (study group) or without (control group) a diagnosis of adenomyosis, 56 and 43 patients in each group, respectively. " 02/01/2014 - "Conservative uterine-sparing surgery for adenomyosis classified as (1) complete excision of adenomyosis, (2) cytoreductive surgery or incomplete removal of the lesion, or (3) nonexcisional techniques, with studies selected if women with adenomyosis were treated surgically without performing hysterectomy. "
3.	Lasers (Laser) 01/01/2007 - "Endometriosis in the RV pouch and RV septum can be effectively treated with laser laparoscopy performed by experienced endoscopic gynaecologists." 05/01/1997 - "Laser laparoscopy is a practical, safe, and effective technique for the management of large ovarian endometriomas." 02/01/1997 - "Efficacy of isotopic 13CO2 laser laparoscopic evaporation in the treatment of infertile patients with minimal and mild endometriosis: a life table cumulative pregnancy rates study." 02/01/1997 - "To assess the efficacy of 13CO2 laser laparoscopy in treating infertile women with minimal to mild endometriosis according the American Fertility Society classification in terms of pregnancy rates. " 06/01/1995 - "Efficacy of laser laparoscopy in minimal endometriosis?"
4.	Laparotomy 07/01/1992 - "Our results validate the therapeutic efficacy of operative laparoscopy in the treatment of moderate and severe endometriosis and confirm the substantial economic and social benefits of laparoscopy surgery over laparotomy." 12/01/2015 - "The gold standard in the diagnosis of intestinal endometriosis is exploratory laparotomy and the pathological study of specimens. " 04/01/2015 - "To investigate the recurrence rate and disease-free interval between laparoscopy versus laparotomy for the conservative surgery of endometrioma. " 02/01/1996 - "To compare the efficacy of laparoscopy versus microsurgery by laparotomy in the treatment of ovarian endometriomas. " 10/01/2015 - "The study population for these analyses includes the ENDO Study (2007-2009) operative cohort: 473 women, ages 18-44 years, who underwent a diagnostic and/or therapeutic laparoscopy or laparotomy at one of 14 surgical centers located in Salt Lake City, UT or San Francisco, CA. Women with a history of surgically confirmed endometriosis were excluded. "
5.	Ovariectomy (Oophorectomy) 02/01/2010 - "Induction of a local pseudo-pregnancy could achieve therapeutic efficacy comparable to that of ovariectomy without provoking any marked side effects in a rabbit endometriosis model. " 02/01/1992 - "In our study, only one suspected endometriosis case received bilateral oophorectomy. " 04/01/2014 - "At 2 weeks after ovariectomy, the mice were transplanted with eutopic endometrium from endometriosis patients either subcutaneously or sutured within the peritoneal, or underwent mock surgery. " 02/01/2013 - "Experimental endometriosis was established in mice via injection of human endometrial tissue within 16 hours of ovariectomy. " 11/01/2012 - "Some patients also had endometriosis in other organs and underwent, for example, wedge resection of sigmoid colon and oophorectomy. "