5-chloro-2-methyl-4-isothiazolin-3-one

RN given refers to parent cpd; structure

Also Known As:

5-chloro-2-methyl-4-isothiazolin-3-one hydrochloride; 5-chloro-2-methylisothiazolin-3-one; 5-chloro-N-methylisothiazolone; 5243-K-Cg; methylchloro-isothiazolinone; methylchloroisothiazolinone

Networked: 118 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 140
- Sulfur Compounds: 283
  - Thiazoles: 411
    - 5-chloro-2-methyl-4-isothiazolin-3-one: 118
Heterocyclic Compounds: 207
- 1-Ring Heterocyclic Compounds
  - Azoles: 2199
    - Thiazoles: 411
      - 5-chloro-2-methyl-4-isothiazolin-3-one: 118

Experts

1.	Isaksson, Marléne: 9 articles (07/2021 - 12/2004)
2.	Goossens, An: 8 articles (07/2021 - 07/2014)
3.	Bruze, Magnus: 7 articles (07/2021 - 12/2004)
4.	Aerts, Olivier: 5 articles (04/2018 - 07/2014)
5.	Johansen, Jeanne D: 4 articles (09/2017 - 11/2013)
6.	Özkaya, Esen: 3 articles (01/2024 - 07/2020)
7.	Geier, Johannes: 3 articles (01/2023 - 12/2012)
8.	Taylor, James S: 3 articles (01/2023 - 01/2016)
9.	Uter, Wolfgang: 3 articles (01/2023 - 12/2012)
10.	Wilkinson, Mark: 3 articles (01/2023 - 04/2013)

Related Diseases

1.	Hypersensitivity (Allergy) 03/01/2015 - "The aim of this study was to study the prevalence of methylchloroisothiazolinone/MI (MCI/MI) and MI allergy in a Bangkok dermatology clinic. " 07/01/2014 - "To report on methylchloroisothiazolinone (MCI)/MI and MI allergy in Belgium. " 01/01/2013 - "Although it might seem likely that testing with methylchloroisothiazolinone (MCI)/MI would be adequate to pick up contact allergy to MI alone, the mix misses approximately 40% of allergy to MI, likely because of the low concentration of MI in the MCI/MI combination patch test. " 01/01/2014 - "Patch testing confirmed an allergy to methylchloroisothiazolinone, a preservative in the moist toilet paper. " 02/01/2020 - "To follow-up on the prevalence of contact allergy to MI in consecutively patch tested patients and assess the spectrum of products containing MI or methylchloroisothiazolinone (MCI)/MI in patients positive to MI which elicited current allergic contact dermatitis. "
2.	Contact Dermatitis (Eczema, Contact) 05/01/2017 - "This is the first North American Contact Dermatitis Group reporting cycle that includes both methylchloroisothiazolinone (MCI)/MI and MI data. " 04/01/2000 - "Airborne contact dermatitis from methylchloroisothiazolinone in wall paint. " 04/01/2018 - "An Italian multicentre study on methylchloroisothiazolinone/methylisothiazolinone contact sensitivity: understanding the structure-activity relationship." 07/01/2021 - "Patch Testing With Methylchloroisothiazolinone/Methylisothiazolinone Using a New Diagnostic Mix-A Multicenter Study From the International Contact Dermatitis Research Group." 09/24/2020 - "In a group of 1137 patients (832 females and 305 males) with suspected contact dermatitis, diagnosed in 2014-2018, patch tests series including methylchloroisothiazolinone/methylisothiazolinone (0.01%) and methylisothiazolinone (0.2%), produced by Chemotechnique Diagnostics, Sweden, were performed. "
3.	Dermatitis 05/01/2019 - "We describe a case of hand dermatitis due to homemade "slime" with a positive patch test to methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) and MI. " 05/15/2010 - "Methylchloroisothiazolinone / methylisothiazolinone and moist wipe dermatitis." 01/01/2016 - "Prevalence of methylchloroisothiazolinone and methylisothiazolinone contact allergy in facial dermatitis: a single centre Irish study." 09/01/2019 - "Allergic Dermatitis to Methylchloroisothiazolinone/Methylisothiazolinone Masquerading as Pinworm Infection." 01/01/2016 - "Contact allergy to methylisothiazolinone (MI) or to the combined formulation of methylchloroisothiazolinone and MI (MCI-MI) has increased significantly, with a frequency of as much as 11.1% in patients with dermatitis; however, few cohort studies in the US population have been reported. "
4.	Lung Injury 04/16/2018 - "Previous animal studies have not conclusively determined the association between exposure to humidifier disinfectants (HDs) containing 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and/or 2-methyl-4-isothiazolin-3-one (MIT) and development of HD-associated lung injuries. "
5.	Allergic Contact Dermatitis 02/01/2019 - "Allergic contact dermatitis caused by glitter glue used as make-up containing methylchloroisothiazolinone." 01/01/2011 - "Allergic contact dermatitis from methylchloroisothiazolinone, with acute exanthematous pustulosis-like histopathologic changes." 02/01/2020 - "To follow-up on the prevalence of contact allergy to MI in consecutively patch tested patients and assess the spectrum of products containing MI or methylchloroisothiazolinone (MCI)/MI in patients positive to MI which elicited current allergic contact dermatitis. " 01/01/2017 - "Preservatives like MI and methylchloroisothiazolinone (MCI) that are both common in products and have a high incidence of allergic contact dermatitis are of greatest concern as contact allergy hazards. " 01/01/2022 - "Methylisothiazolinone (MI) and Methylchloroisothiazolinone (MCI) are among the most common skin sensitizers, yet the immunological events that occur during MCI/MI allergic contact dermatitis (ACD) are still poorly understood. "

Related Drugs and Biologics

1.	2-methyl-4-isothiazolin-3-one
2.	Disinfectants (Biocides)
3.	Kathon 886
4.	Cosmetics
5.	Allergens
6.	Formaldehyde (Formol)
7.	Nickel
8.	1,2-benzisothiazoline-3-one (benzisothiazolinone)
9.	Thiram
10.	Solutions

Related Therapies and Procedures

1.	Humidifiers
2.	Bathroom Equipment