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psb-603

Also Known As:

8-(4-(4-(4-chlorophenyl)piperazine-1-sulfonyl)phenyl)-1-propyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Müller, Christa E: 2 articles (05/2021 - 03/2021)
2.	Li, Jinxia: 1 article (01/2022)
3.	Li, Yilu: 1 article (01/2022)
4.	Li, Yunhong: 1 article (01/2022)
5.	Ma, Quanrui: 1 article (01/2022)
6.	Ma, Teng: 1 article (01/2022)
7.	Sun, Jinping: 1 article (01/2022)
8.	Wang, Dan: 1 article (01/2022)
9.	Wang, Junyan: 1 article (01/2022)
10.	Wang, Yin: 1 article (01/2022)

Related Diseases

1.	Inflammation (Inflammations) 03/01/2021 - "Additionally, in the latter model, no statistically significant difference was observed in the CRP level between the control group without inflammation and the group which has been treated with the PSB-603 compound. " 03/01/2021 - "The aim of this preliminary study was to determine the potential anti-inflammatory properties of compound PSB-603, a potent and selective adenosine A2B receptor antagonist, in two different experimental models of local and systemic inflammation. " 01/01/2022 - "The results showed that treatment of PSB-603, an A2BAR selective antagonist, greatly ameliorated cerebral ischemic injury by increasing bodyweights, reducing infarct volume, brain injury,inflammation andcontributing to long-term learning memory functionalrecoveryof the PVL mice. "
2.	Body Weight (Weight, Body) 11/03/2022 - "Both theophylline and PSB-603 significantly reduced body weight in obese mice. " 11/03/2022 - "The present study investigated the link between body weight reduction, glucose homeostasis, and anti-inflammatory activity induced by a highly potent and specific adenosine A2B receptor antagonist, compound PSB-603. "
3.	Colorectal Neoplasms (Colorectal Cancer) 12/01/2016 - "Although requiring more mechanistic insight into its A2b-AR-independent activity, our results show that PSB-603 may have clinical value as an anti-colorectal cancer therapeutic." 12/01/2016 - "PSB-603 alters cellular metabolism in colorectal cancer cells and increases their sensitivity to chemotherapy. " 12/01/2016 - "PSB-603 also induced acute increases in reactive oxygen species, and PSB-603 synergized with chemotherapy treatment to increase colorectal cancer cell death, consistent with the known link between cellular metabolism and chemotherapy response. " 12/01/2016 - "The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism."
4.	Prostatic Neoplasms (Prostate Cancer) 04/01/2016 - "Proliferation of multiple prostate cancer cell lines was also attenuated in the presence of PSB-603. "
5.	Obesity 11/03/2022 - "Preliminary Evidence of the Potent and Selective Adenosine A2B Receptor Antagonist PSB-603 in Reducing Obesity and Some of Its Associated Metabolic Disorders in Mice."

Related Drugs and Biologics

1.	Adenosine A2B Receptor
2.	Glucose (Dextrose)
3.	Purinergic P1 Receptor Antagonists
4.	Xanthine
5.	Purinergic P1 Receptors (Adenosine Receptor)
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Theophylline (Theon)
8.	Radioisotopes (Radionuclides)
9.	Adenosine (Adenocard)
10.	Fluorine-18

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)