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yoda-1

small molecule activator of Piezo-1

Also Known As:

2-((2,6-dichlorophenyl)methylsulfanyl)-5-pyrazin-2-yl-1,3,4-thiadiazole

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Thiadiazoles: 99
        yoda-1: 3
  - Pyrazines: 150
    - yoda-1: 3
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - Thiadiazoles: 99
      - yoda-1: 3

Experts

1.	Cobb, Stuart: 1 article (01/2020)
2.	Dev, Kumlesh K: 1 article (01/2020)
3.	Gadalla, Kamal K E: 1 article (01/2020)
4.	Liñan-Barba, Núria: 1 article (01/2020)
5.	Sheridan, Graham K: 1 article (01/2020)
6.	Velasco-Estevez, María: 1 article (01/2020)
7.	Apta, Bonita H R: 1 article (10/2019)
8.	Davies, Jessica E: 1 article (10/2019)
9.	Harper, Matthew T: 1 article (10/2019)
10.	Lin, Zhiyuan: 1 article (10/2019)

Related Diseases

1.	Inflammation (Inflammations) 10/01/2019 - "In this study, we investigated whether a small molecule activator of Piezo-1, Yoda-1, can mimic the effect of laminar flow-induced shear stress on endothelial cell inflammation, and endothelial cytotoxicity in response to the chemotherapy agent, doxorubicin. "
2.	Hyperglycemia 01/01/2023 - "Furthermore, in arteries and microvessels, inhibition of Piezo1 using GsMTx4 prevented the hyperglycemia -effect, while Yoda-1 caused relaxation and dilation, respectively. " 01/01/2023 - "In human umbilical vein endothelial cells, hyperglycemia, and the Piezo1 activator Yoda-1 increased levels of Piezo1 protein, p-CaMKII (phosphorylated Ca2+/Calmodulin-dependent protein kinase type II), Akt (protein kinase B), and p-eNOS (phosphorylated eNOS). "
3.	Demyelinating Diseases (Demyelinating Disease) 01/01/2020 - "In contrast, the positive modulator of Piezo1 channel opening, Yoda-1, induces demyelination and neuronal damage. "

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