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JHU083

a glutamine antagonist

Also Known As:

ethyl (2S)-2-(((2S)-2-amino-4-methylpentanoyl)amino)-6-diazo-5-oxohexanoate

Networked: 6 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Caproates: 7
      - JHU083: 6
- Azo Compounds: 333
  - JHU083: 6
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Caproates: 7
      - JHU083: 6

Experts

1.	Kamiya, Atsushi: 3 articles (08/2022 - 01/2019)
2.	Slusher, Barbara S: 3 articles (08/2022 - 01/2019)
3.	Zhu, Xiaolei: 3 articles (08/2022 - 01/2019)
4.	Alt, Jesse: 2 articles (09/2021 - 01/2019)
5.	Chao, Wei: 2 articles (09/2021 - 01/2019)
6.	Dash, Ranjeet P: 2 articles (09/2021 - 01/2019)
7.	Hadas, Eran: 2 articles (09/2021 - 01/2019)
8.	Kelschenbach, Jennifer: 2 articles (09/2021 - 01/2019)
9.	Kim, Boe-Hyun: 2 articles (09/2021 - 01/2019)
10.	Lovell, Lyndah E: 2 articles (09/2021 - 01/2019)

Related Diseases

1.	Infections 11/16/2023 - "When tested in an immunocompromised mouse model of Mtb infection, JHU083 loses its therapeutic efficacy suggesting the drug's host-directed effects are likely to be predominant. " 02/23/2023 - "When tested in an immunocompromised mouse model of Mtb infection, JHU083 lost its therapeutic efficacy suggesting the drug's host-directed effects are likely to be predominant. "
2.	Neurocognitive Disorders (Clerambault Syndrome) 01/01/2019 - " Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders ." 09/01/2021 - "Correction to: Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders." 01/01/2019 - "Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders."
3.	Carcinogenesis 01/01/2022 - "Here, the authors report that JHU083, an orally active glutamine antagonist prodrug designed to be preferentially activated in the tumor microenvironment, has potent anticancer effects on EGFR-driven mouse lung tumorigenesis. "
4.	Cognitive Dysfunction 01/01/2019 - "Systemic administration of JHU083 reversed cognitive impairment in EcoHIV-infected mice similarly to DON, and simultaneously normalized EcoHIV-induced increases in cerebrospinal fluid (CSF) glutamate and GLS activity in microglia-enriched brain CD11b + cells without observed toxicity. "
5.	HIV Infections (HIV Infection) 08/01/2022 - "Thus, brain-penetrable GLS inhibitors like JHU083 could act as a potential therapeutic modality for both glutamate excitotoxicity and aberrant immune activation in microglia in chronic HIV infection."

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	Glutamine (L-Glutamine)
3.	Prodrugs