nidoviral uridylate-specific endoribonuclease

Also Known As:

Deltacoronavirus (PDCoV) nsp15; NSP15 protein, SARS-CoV-2; NendoU; Nsp11 protein, arterivirus; Nsp15 protein, MERS-CoV; Nsp15 protein, Middle East Respiratory Syndrome Coronavirus; Nsp15 protein, SARS-CoV; PDCoV nsp15 protein; endoRNAse, SARS-CoV-2; nonstructural protein 15, SARS coronovirus; nsp11 protein, Betaarterivirus suid 1; nsp11 protein, PRRSV; nsp11 protein, porcine reproductive and respiratory syndrome virus; nsp15 protein, porcine Deltacoronavirus; nsp15B-NendoU protein, SARS-CoV-2

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Durvasula, Ravi: 1 article (10/2021)
2.	Dye, John M: 1 article (10/2021)
3.	Gupta, Yash: 1 article (10/2021)
4.	Herbert, Andrew S: 1 article (10/2021)
5.	Kempaiah, Prakasha: 1 article (10/2021)
6.	Kumar, Sumit: 1 article (10/2021)
7.	Poonam,: 1 article (10/2021)
8.	Potemkin, Vladimir: 1 article (10/2021)
9.	Rathi, Brijesh: 1 article (10/2021)
10.	Sharma, Neha: 1 article (10/2021)

Related Diseases

1.	Neoplasms (Cancer) 10/04/2011 - "Notably, XendoU family members have been implicated in human pathologies such as cancer and respiratory diseases: PP11 is aberrantly expressed in various tumors, while NendoU activity has been associated with respiratory infections by pathogenic coronaviruses. " 12/01/2015 - "Screening all of the 12 nonstructural proteins (Nsps) encoded by PRRSV revealed that, apart from the Nsp2 which contains the deubiqintinating (DUB) ovarian tumor (OTU) domain, Nsp11, which encodes a unique and conserved endoribonuclease (NendoU) throughout the Nidovirus order, also possesses DUB activity. "
2.	Respiratory Tract Infections (Respiratory Tract Infection) 10/04/2011 - "Notably, XendoU family members have been implicated in human pathologies such as cancer and respiratory diseases: PP11 is aberrantly expressed in various tumors, while NendoU activity has been associated with respiratory infections by pathogenic coronaviruses. "
3.	Respiratory Tract Diseases (Respiratory Tract Disease) 10/04/2011 - "Notably, XendoU family members have been implicated in human pathologies such as cancer and respiratory diseases: PP11 is aberrantly expressed in various tumors, while NendoU activity has been associated with respiratory infections by pathogenic coronaviruses. "
4.	COVID-19 10/20/2021 - "Therefore, this novel class of NendoU inhibitor could provide new insights for the development of treatment options for COVID-19."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Endoribonucleases