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3'-deoxy-3',4'-didehydro-CTP

naturally-encoded vertebrate ribonucleotide with antiviral activity

Also Known As:

ddhCTP

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleotides: 48
      - Cytosine Nucleotides: 10
        Cytidine Triphosphate: 2076
        3'-deoxy-3',4'-didehydro-CTP: 3
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Ribonucleotides: 307
    - Cytosine Nucleotides: 10
      - Cytidine Triphosphate: 2076
        3'-deoxy-3',4'-didehydro-CTP: 3
  - Pyrimidine Nucleotides: 48
    - Cytosine Nucleotides: 10
      - Cytidine Triphosphate: 2076
        3'-deoxy-3',4'-didehydro-CTP: 3

Experts

1.	Browne, Cathy: 1 article (01/2020)
2.	Honarmand Ebrahimi, Kourosh: 1 article (01/2020)
3.	James, William S: 1 article (01/2020)
4.	McCullagh, James: 1 article (01/2020)
5.	Vowles, Jane: 1 article (01/2020)
6.	Dumbrepatil, Arti B: 1 article (01/2019)
7.	Ghosh, Soumi: 1 article (01/2019)
8.	Hoff, J Damon: 1 article (01/2019)
9.	Kennedy, Robert T: 1 article (01/2019)
10.	Malec, Paige A: 1 article (01/2019)

Related Diseases

1.	Virus Diseases (Viral Diseases) 01/01/2020 - "We propose that ddhCTP regulates cellular metabolism in response to inflammatory stimuli such as viral infection, pointing to a broader function of RSAD2 than previously thought." 01/01/2022 - "These results suggest that nsp14 ExoN could play a role in protecting SARS-CoV-2 from ddhCTP, which is produced as part of the innate immune response against viral infections, and that the SARS-CoV-2 enzymes may have adapted to minimize the antiviral effect of ddhCTP."
2.	Dehydration (Water Stress) 01/01/2019 - "We show that IRAK1 and TRAF6 increase viperin activity ∼10-fold to efficiently catalyze the radical-mediated dehydration of CTP to ddhCTP. "

Related Drugs and Biologics

1.	TNF Receptor-Associated Factor 6 (TRAF6)
2.	Enzymes
3.	Cytidine Triphosphate (CTP)
4.	Antiviral Agents (Antivirals)