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TRL1068

a high-affinity human monoclonal antibody against bacterial DNABII epitope

Also Known As:

TRL1068 monoclonal antibody

Networked: 3 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kauvar, Lawrence M: 3 articles (09/2023 - 04/2016)
2.	Tenorio, Edgar: 3 articles (09/2023 - 04/2016)
3.	Estellés, Angeles: 2 articles (10/2017 - 04/2016)
4.	Leighton, Anton: 2 articles (10/2017 - 04/2016)
5.	Ryser, Stefan: 2 articles (10/2017 - 04/2016)
6.	Bernthal, Nicholas M: 1 article (09/2023)
7.	Blumstein, Gideon W: 1 article (09/2023)
8.	Burke, Zachary D C: 1 article (09/2023)
9.	Cevallos, Nicolas: 1 article (09/2023)
10.	Hamad, Christopher: 1 article (09/2023)

Related Diseases

1.	Infections 09/28/2023 - "TRL1068 represents a promising systemic treatment for orthopedic implant infection." 10/01/2017 - "In parallel, the in vivo efficacy of TRL1068 against a multidrug-resistant clinical Acinetobacter baumannii isolate was explored by using an established mouse model of skin and soft tissue catheter-related biofilm infection. "
2.	Body Weight (Weight, Body) 04/01/2016 - "Treatment of the established biofilm by combination therapy of TRL1068 (15 mg/kg of body weight, intraperitoneal [i.p.] administration) with daptomycin (50 mg/kg, i.p.) significantly reduced adherent bacterial count compared to that after daptomycin treatment alone, accompanied by significant reduction in planktonic bacterial numbers. "
3.	Bacterial Infections (Bacterial Infection) 10/01/2017 - "TRL1068 shows excellent promise as an adjunct to standard-of-care antibiotics for a broad range of difficult-to-treat bacterial infections." 04/01/2016 - "TRL1068 is a clinical candidate for combination treatment with standard-of-care antibiotics to overcome the drug-refractory state associated with biofilm formation, with potential utility for a broad spectrum of difficult-to-treat bacterial infections. "

Related Drugs and Biologics

1.	Daptomycin
2.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Catheters
2.	Therapeutics